Opposite Effects of Recombinant Human Transforming Growth Factor-β1 on Bone Regeneration In Vivo: Effects of Exclusion of Periosteal Cells by Microporous Membrane

Bone ◽  
1998 ◽  
Vol 22 (6) ◽  
pp. 613-620 ◽  
Author(s):  
G Zellin ◽  
S Beck ◽  
R Hardwick ◽  
A Linde
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Microporous Membrane ◽  
Periosteal Cells ◽  
In Vivo Effects

In vivo induction of bone by recombinant human transforming growth factor β1

2009 ◽  
Vol 6 (9) ◽  
pp. 961-968 ◽  
Author(s):  
L. Steven Beck ◽  
Arthur J. Ammann ◽  
Thomas B. Aufdemorte ◽  
Leo Deguzman ◽  
Yvette Xu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
In Vivo Induction

In vivo effects of transforming growth factor-β2 in ovariectomized rats

1993 ◽  
Vol 22 (3) ◽  
pp. 209-220 ◽  
Author(s):  
Dike N. Kalu ◽  
Elena Salerno ◽  
Yoshikazu Higami ◽  
Chung Ching Liu ◽  
Fabrizio Ferraro ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Ovariectomized Rats ◽  
Transforming Growth Factor Β2 ◽  
In Vivo Effects

A blocking peptide for transforming growth factor-β1 activation prevents hepatic fibrosis in vivo

2003 ◽  
Vol 39 (5) ◽  
pp. 742-748 ◽  
Author(s):  
Hiroki Kondou ◽  
Sotaro Mushiake ◽  
Yuri Etani ◽  
Yoko Miyoshi ◽  
Toshimi Michigami ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatic Fibrosis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1

scholarly journals Increased serum and bone matrix levels of transforming growth factor β1 in patients with GH deficiency in response to GH treatment

2011 ◽  
Vol 165 (3) ◽  
pp. 393-400 ◽  
Author(s):  
Thor Ueland ◽  
Tove Lekva ◽  
Kari Otterdal ◽  
Tuva B Dahl ◽  
Nicoleta Cristina Olarescu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cortical Bone ◽  
Transforming Growth Factor ◽  
Bone Cells ◽  
Gh Deficiency ◽  
Bone Matrix ◽  
Transforming Growth Factor Β1 ◽  
Gh Treatment

ObjectivePatients with adult onset GH deficiency (aoGHD) have secondary osteoporosis, which is reversed by long-term GH substitution. Transforming growth factor β1 (TGFβ1 or TGFB1) is abundant in bone tissue and could mediate some effects of GH/IGFs on bone. We investigated its regulation by GH/IGF1in vivoandin vitro.Design and methodsThe effects of GH substitution (9–12 months, placebo controlled) on circulating and cortical bone matrix contents of TGFβ1 were investigated in patients with aoGHD. The effects of GH/IGF1 on TGFβ1 secretion in osteoblasts (hFOB), adipocytes, and THP-1 macrophages as well as the effects on release from platelets were investigatedin vitro.ResultsIn vivoGH substitution increased TGFβ1 protein levels in cortical bone and serum.In vitro, GH/IGF1 stimulation induced a significant increase in TGFβ1 secretion in hFOB. In contrast, no major effect of GH/IGF1 on TGFβ1 was found in adipocytes and THP-1 macrophages. Finally, a minor modifying effect on SFLLRN-stimulated platelet release of TGFβ1 was observed in the presence of IGF1.ConclusionGH substitution increases TGFβ1in vivoandin vitro, and this effect could contribute to improved bone metabolism during such therapy, potentially reflecting direct effect of GH/IGF1 on bone cells.

Sign in / Sign up

Export Citation Format

Share Document