Transplantation of Allograft Transforming Growth Factor–β1 Transfected CD103+ Lamina Propria Dendritic Cells Could Effectively Induce Antigen-Specific Regulatory T Cells In Vivo

2013 ◽  
Vol 45 (9) ◽  
pp. 3408-3413 ◽  
Author(s):  
J. Yuan ◽  
G. Zhang ◽  
X. Yang ◽  
K. Liu ◽  
F. Wang
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Lamina Propria ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1

scholarly journals Hepatocellular Carcinoma Cells Induce Regulatory T Cells and Lead to Poor Prognosis via Production of Transforming Growth Factor-β1

2016 ◽  
Vol 38 (1) ◽  
pp. 306-318 ◽  
Author(s):  
Yi Wang ◽  
Taotao Liu ◽  
Wenqing Tang ◽  
Bin Deng ◽  
Yanjie Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Poor Prognosis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
In Vivo Experiments ◽  
Tgf Β1

Background/Aims: Regulatory T cells (Tregs) are associated with a poor prognosis in hepatocellular carcinoma (HCC). The purpose of the study was to explore the mechanisms of Tregs accumulation in HCC. Methods: We analyzed the frequency of Tregs in HCC by flow cytometry and immunohistochemistry. We also established a transforming growth factor (TGF)-β1-knockdown cell line by lentivirus-mediated RNA interference. Mouse CD4+CD25- T cells were cultured in supernatants from various cell lines. Results: HCC patients had a high frequency of Tregs, and high numbers of Tregs correlated with a poor prognosis. Liver cancer cells induced Treg production by secreting TGF-β1. In vivo experiments indicated that knockdown of TGF-β1 reduced the numbers of Tregs and metastatic nodules in mice. Conclusions: These results indicate that cancer-secreted TGF-β1 may increase Tregs, and TGF-β1 knockdown might impair immunosuppression in the tumor microenvironment by decrease Tregs.

CD28 disruption exacerbates inflammation in Tgf-β1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-β1

Blood ◽  
2004 ◽  
Vol 103 (12) ◽  
pp. 4594-4601 ◽  
Author(s):  
Mizuko Mamura ◽  
WoonKyu Lee ◽  
Timothy J. Sullivan ◽  
Angelina Felici ◽  
Anastasia L. Sowers ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Cytotoxic T Lymphocyte ◽  
Tumor Necrosis Factor Receptor ◽  
Transforming Growth Factor Β1 ◽  
Autoimmune Inflammatory Disease ◽  
Lymph Node Cells ◽  
Tgf Β1

Abstract Tgf-β1-/- mice develop a progressive, lethal, inflammatory syndrome, but mechanisms leading to the spontaneous activation of Tgf-β1-/- T cells remain unclear. Here we show the disruption of CD28 gene expression accelerates disease in Tgf-β1-/- mice, and we link this increase in severity to a reduction in the number of CD4+CD25+ regulatory T cells. CD4+CD25+ T cells develop normally in Tgf-β1-/- mice and display characteristic expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), glucocorticoid-induced tumor necrosis factor receptor (GITR), αEβ7 integrin, and Foxp3. Adoptive transfer of Tgf-β1-/- splenocytes to Tgf-β1+/+/Rag2-/- mice induced an autoimmune inflammatory disease with features similar to those of the Tgf-β1-/- phenotype, and disease transfer was accelerated by the depletion of Tgf-β1-/- CD4+CD25+ T cells from donor splenocytes. Cotransfer of Tgf- β1-/- CD4+CD25+ T cells clearly attenuated disease in Rag2-/- recipients of CD25+-depleted Tgf-β1-/- spleen and lymph node cells, but suppression was incomplete when compared with Tgf-β1+/+ CD4+CD25+ T cells. These data demonstrate that CD4+CD25+ regulatory T cells develop in complete absence of endogenous transforming growth factor-β1 (TGF-β1) expression and that autocrine TGF-β1 expression is not essential for these cells to suppress inflammation in vivo. (Blood. 2004;103:4594-4601)

scholarly journals All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities

2013 ◽  
Vol 94 (5) ◽  
pp. 981-989 ◽  
Author(s):  
Siddharth Jhunjhunwala ◽  
Leo C. Chen ◽  
Erin E. Nichols ◽  
Angus W. Thomson ◽  
Giorgio Raimondi ◽  
...  
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Correlation of interleukin 6 and transforming growth factor β1 with peripheral blood regulatory T cells in rheumatoid arthritis patients: a potential biomarker

2018 ◽  
Vol 43 (3) ◽  
pp. 281-288 ◽  
Author(s):  
Majid Khoshmirsafa ◽  
Farhad Seif ◽  
Nader Bagheri ◽  
Pezhman Beshkar ◽  
Mohammad Mousavi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Interleukin 6 ◽  
Peripheral Blood ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Potential Biomarker

scholarly journals LIVER DENDRITIC CELLS RESIST THE EFFECTS OF RETINOIC ACID AND TRANSFORMING GROWTH FACTOR-B FOR THE INDUCTION OF FOXP3+ REGULATORY T CELLS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 488
Author(s):  
A Thomson ◽  
D Tokita ◽  
C S. Gandhi ◽  
T Sumpter
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Factor B

Costimulatory strength influences the differential effects of transforming growth factor β1 for the generation of CD8+ regulatory T cells☆

2008 ◽  
Vol 45 (10) ◽  
pp. 2937-2950 ◽  
Author(s):  
Timothy M. Fan ◽  
David M. Kranz ◽  
Richard A. Flavell ◽  
Edward J. Roy
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Differential Effects
Sign in / Sign up

Export Citation Format

Share Document