The chapter discusses personality disorders, which are defined as pervasive, enduring, inflexible patterns of dysfunctional behavior linked to abnormal configurations of personality traits. Specifically, this chapter focuses on borderline personality disorder (BPD), narcissistic personality disorder (NPD), obsessive-compulsive personality disorder (OCPD), and avoidant personality disorder (APD). After an overview of these disorders, their developmental features, and the main risk factors identified in the epidemiological literature, the chapter critically reviews existing evolutionary models and suggests new directions for research. The final section applies the criteria developed earlier in the book to classify the disorders within the fast-slow-defense (FSD) model. The author proposes to classify BPD and NPD as fast spectrum (F-type) conditions, OCPD as a slow spectrum (S-type) condition, and APD as a defense activation (D-type) condition characterized by chronic social anxiety.