scholarly journals Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children

2006 ◽  
Vol 96 (6) ◽  
pp. 1134-1139 ◽  
Author(s):  
Xiao-Ming Lin ◽  
Cheng-Ye Ji ◽  
Wen-Jing Liu ◽  
Zhu Long ◽  
Xiao-Yi Shen
Keyword(s):  
Transferrin Receptor ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Fe Deficiency ◽  
Serum Transferrin ◽  
Diagnostic Efficacy ◽  
Republic Of China ◽  
Serum Transferrin Receptor ◽  
Before And After

The object of the present study was to investigate the levels of serum transferrin receptor (sTfR) and its response to Fe supplementation in Fe-deficient children and the role of sTfR in detecting Fe deficiency and assessing the efficacy of Fe supplementation. According to the diagnostic standard, 1006 children, aged 6–14 years in Fangshan district, Beijing, Peoples Republic of China, were divided into four groups: normal; Fe store depletion (IDs); Fe deficiency erythropoiesis (IDE); Fe deficiency anaemia (IDA). sTfR was determined and transferrin receptor-ferritin (TfR-F) index was calculated in 238 children, sixty-four normal and 174 Fe deficient. Children were administered a NaFeEDTA capsule containing 60 mg Fe once per week for the IDs and IDE groups and three times per week for the IDA group for nine consecutive weeks. The parameters reflecting Fe status and sTfR were determined before and after Fe supplementation. The levels of sTfR and TfR-F index in Fe-deficient children were significantly higher than those in the normal group. The receiver operating characteristic curve showed that sTfR has proper diagnostic efficacy for functional Fe deficiency. After Fe supplementation, the level of sTfR was significantly decreased in children with IDs, but not in children with IDE and IDA, while TfR-F index was significantly decreased in Fe-deficient children. sTfR is a reliable indicator for detecting functional Fe deficiency, and TfR-F index is a sensitive parameter for assessing the efficacy of Fe supplementation.

scholarly journals Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age

2008 ◽  
Vol 100 (5) ◽  
pp. 1104-1108 ◽  
Author(s):  
Xiao-Ming Lin ◽  
Juan Zhang ◽  
Zhi-Yong Zou ◽  
Zhu Long ◽  
Wei Tian
Keyword(s):  
Roc Curve ◽  
Transferrin Receptor ◽  
Operating Characteristic ◽  
Significant Negative Correlation ◽  
Effective Rate ◽  
Fe Deficiency ◽  
Serum Transferrin ◽  
Diagnostic Efficacy ◽  
Serum Transferrin Receptor ◽  
Child Bearing

The objective was to study the evaluation of serum transferrin receptor (sTfR) for Fe deficiency in women of child-bearing age. Primary screening was performed in 942 women ranging in child-bearing age. Serum ferritin (SF), Zn protoporphyrin (ZPP) and Hb were determined. Then the subjects were divided into four groups: normal, Fe store depletion (IDs), Fe-deficiency erythropoiesis and Fe-deficiency anaemia. sTfR was determined and sTfR/SF (sTfR/logSF and log(sTfR/SF)) was calculated. Changes of sTfR in women of different Fe status were observed. A receiver-operating characteristic (ROC) curve was used to evaluate whether sTfR had proper diagnostic efficacy for functional Fe deficiency. The levels of sTfR increased significantly along with the aggravation of Fe deficiency. Increase of STfR/SF along with the aggravation of Fe deficiency was more significant than that of sTfR. STfR had a significant negative correlation with SF and Hb, while it had a significant positive correlation with ZPP. The ROC curve showed that the diagnostic effective rate of sTfR for Fe deficiency could reach 83 %. At this point, the sensitivity was 79 % and the specificity was 63 %. Log(sTfR/SF) could be considered to have the highest effective ratio in detecting IDs, since it reached 99 %. STfR and sTfR/SF could both reflect body Fe-deficiency status specifically. They could be used as reliable indicators for evaluating Fe status and diagnosing Fe deficiency in women of child-bearing age.

scholarly journals The Role of Serum Transferrîn Receptor in the Diagnosis of Iron Deficiency of Pregnant Women

2005 ◽  
Vol 15 (3) ◽  
pp. 155-161
Author(s):  
Berna Atabay ◽  
Işın Yaprak ◽  
Abdurrahman Gül ◽  
Sadık Akşit ◽  
Feyza Umay ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

scholarly journals Evaluation of a multiparametric MRI radiomic-based approach for stratification of equivocal PI-RADS 3 and upgraded PI-RADS 4 prostatic lesions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Valentina Brancato ◽  
Marco Aiello ◽  
Luca Basso ◽  
Serena Monti ◽  
Luigi Palumbo ◽  
...  
Keyword(s):  
Characteristic Curve ◽  
Multiparametric Mri ◽  
Order Model ◽  
Diagnostic Efficacy ◽  
Dce Mri ◽  
Contrast Enhanced ◽  
Before And After ◽  
Apparent Diffusion ◽  
Adc Map

AbstractDespite the key-role of the Prostate Imaging and Reporting and Data System (PI-RADS) in the diagnosis and characterization of prostate cancer (PCa), this system remains to be affected by several limitations, primarily associated with the interpretation of equivocal PI-RADS 3 lesions and with the debated role of Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI), which is only used to upgrade peripheral PI-RADS category 3 lesions to PI-RADS category 4 if enhancement is focal. We aimed at investigating the usefulness of radiomics for detection of PCa lesions (Gleason Score ≥ 6) in PI-RADS 3 lesions and in peripheral PI-RADS 3 upgraded to PI-RADS 4 lesions (upPI-RADS 4). Multiparametric MRI (mpMRI) data of patients who underwent prostatic mpMRI between April 2013 and September 2018 were retrospectively evaluated. Biopsy results were used as gold standard. PI-RADS 3 and PI-RADS 4 lesions were re-scored according to the PI-RADS v2.1 before and after DCE-MRI evaluation. Radiomic features were extracted from T2-weighted MRI (T2), Apparent diffusion Coefficient (ADC) map and DCE-MRI subtracted images using PyRadiomics. Feature selection was performed using Wilcoxon-ranksum test and Minimum Redundancy Maximum Relevance (mRMR). Predictive models were constructed for PCa detection in PI-RADS 3 and upPI-RADS 4 lesions using at each step an imbalance-adjusted bootstrap resampling (IABR) on 1000 samples. 41 PI-RADS 3 and 32 upPI-RADS 4 lesions were analyzed. Among 293 radiomic features, the top selected features derived from T2 and ADC. For PI-RADS 3 stratification, second order model showed higher performances (Area Under the Receiver Operating Characteristic Curve—AUC— = 80%), while for upPI-RADS 4 stratification, first order model showed higher performances respect to superior order models (AUC = 89%). Our results support the significant role of T2 and ADC radiomic features for PCa detection in lesions scored as PI-RADS 3 and upPI-RADS 4. Radiomics models showed high diagnostic efficacy in classify PI-RADS 3 and upPI-RADS 4 lesions, outperforming PI-RADS v2.1 performance.

scholarly journals Soluble serum transferrin receptor and transferrin receptor-ferritin index in anemia of chronic kidney disease

2006 ◽  
Vol 35 (8) ◽  
pp. 520-543 ◽  
Author(s):  
Sandra Margetic ◽  
Elizabeta Topic ◽  
Andrea Tesija-Kuna ◽  
Ines Vukasovic
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

scholarly journals Erythroblastic Inclusions in Dominantly Inherited β Thalassemias

Blood ◽  
1997 ◽  
Vol 89 (1) ◽  
pp. 322-328 ◽  
Author(s):  
P. Joy Ho ◽  
Sunitha N. Wickramasinghe ◽  
David C. Rees ◽  
Matthew J. Lee ◽  
Ayed Eden ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Inclusion Bodies ◽  
Serum Transferrin ◽  
Mrna Transcript ◽  
Globin Chain ◽  
Prominent Feature ◽  
Ineffective Erythropoiesis ◽  
Serum Transferrin Receptor ◽  
Globin Chains ◽  
Cellular Pathology

While the precipitation of unstable variant β-globin chains has been implicated as a major pathogenic mechanism in dominantly inherited β thalassemia, their instability and presence in intra-erythroblastic inclusions have not been conclusively shown. We report the investigation of two cases of dominantly inherited β thalassemia due to heterozygosity for the β-codon 121 G-T mutation. In one case, we were able to demonstrate the presence of an abnormal β-globin chain in both peripheral blood reticulocytes and bone marrow erythroblasts, and to assess its stability in relation to the substantial amounts of mutant β mRNA transcript. The serum transferrin receptor (TfR) level was markedly increased, an indication of increased erythropoietic activity. In both cases, we could show by immunoelectron microscopy that the intra-erythroblastic inclusion bodies, a prominent feature of diseases in this category, contained not only precipitated α-globin chains, but also β chains. The data confirm previous suggestions that the cellular pathology underlying this group of β thalassemias is related to the synthesis of highly unstable β-globin chain variants, which fail to form functional tetramers and precipitate intracellularly with the concomitant excess α chains, leading to increased ineffective erythropoiesis.

scholarly journals Serum Transferrin Receptor Levels in Different Stages of Iron Deficiency

Blood ◽  
1997 ◽  
Vol 90 (3) ◽  
pp. 1332-1333
Author(s):  
E. Gimferrer ◽  
J. Ubeda ◽  
M.T. Royo ◽  
G.J. Marigó ◽  
N. Marco ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

EPO, red cells, and serum transferrin receptor in continuous and intermittent hypoxia

2000 ◽  
Vol 32 (4) ◽  
pp. 800-804 ◽  
Author(s):  
PENTTI O. KOISTINEN ◽  
HEIKKI RUSKO ◽  
KERTTU IRJALA ◽  
ALLAN RAJAM??KI ◽  
KENNETH PENTTINEN ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Intermittent Hypoxia ◽  
Red Cells ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

The role of venous pressure variability during hemodialysis in the prediction of impending arteriovenous graft occlusion

2021 ◽  
pp. 112972982110573
Author(s):  
Yuan-Hsi Tseng ◽  
Min Yi Wong ◽  
Chih-Chen Kao ◽  
Chien-Chao Lin ◽  
Ming-Shian Lu ◽  
...  
Keyword(s):  
Operating Characteristic ◽  
Characteristic Curve ◽  
Venous Pressure ◽  
Blood Flow Rate ◽  
Curve Analysis ◽  
Graft Occlusion ◽  
Arteriovenous Graft ◽  
Significant Elevation ◽  
Operating Characteristic Curve

Background: Elevated venous pressure during hemodialysis (VPHD) is associated with arteriovenous graft (AVG) stenosis. This study investigated the role of VPHD variations in the prediction of impending AVG occlusion. Methods: Data were retrieved from 118 operations to treat AVG occlusion (occlusion group) and 149 operations to treat significant AVG stenosis (stenosis group). In addition to analyzing the VPHD values for the three hemodialysis (HD) sessions prior to the intervention, VPHD values were normalized to mean blood pressure (MBP), blood flow rate (BFR), BFR × MBP, and BFR2 × MBP to yield ratios for analysis. The coefficient of variation (CV) was used to measure relative variations. Results: The within-group comparisons for both groups revealed no significant differences in the VPHD mean and CV values among the three HD sessions prior to intervention. However, the CVs for VPHD/MBP, VPHD/(BFR × MBP), and VPHD/(BFR2 × MBP) exhibited significant elevation in the occlusion group during the last HD session prior to intervention compared with both the penultimate and antepenultimate within-group HD data ( p < 0.05). In the receiver operating characteristic curve analysis, the CV for VPHD/(BFR2 × MBP) was the only parameter able to discriminate between the last and the penultimate HD outcomes ( p < 0.001). According to a multivariate analysis, after controlling for covariates, CV for VPHD/(BFR2 × MBP) >8.76% was associated with a higher risk of AVG thrombosis (odds ratio: 3.17, p < 0.001). Conclusions: Increasing the variation in VPHD/(BFR2 × MBP) may increase the probability of AVG occlusion.

scholarly journals Increased Serum Transferrin Saturation Is Associated with Lower Serum Transferrin Receptor Concentration

1999 ◽  
Vol 45 (12) ◽  
pp. 2191-2199 ◽  
Author(s):  
Anne C Looker ◽  
Mark Loyevsky ◽  
Victor R Gordeuk
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Transferrin Receptor ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Reference Interval ◽  
Serum Transferrin ◽  
Reactive Protein ◽  
Serum Transferrin Receptor ◽  
Health And Nutrition

Abstract Background: Serum transferrin receptor (sTfR) concentrations are increased in iron deficiency. We wished to examine whether they are decreased in the presence of potential iron-loading conditions, as reflected by increased transferrin saturation (TS) on a single occasion. Methods: We compared sTfR concentrations between 570 controls with normal iron status and 189 cases with increased serum TS on a single occasion; these latter individuals may be potential cases of iron overload. Cases and controls were selected from adults who had been examined in the third National Health and Nutrition Examination Survey (1988–1994) and for whom excess sera were available to perform sTfR measurements after the survey’s completion. Increased TS was defined as &gt;60% for men and &gt;55% for women; normal iron status was defined as having no evidence of iron deficiency, iron overload, or inflammation indicated by serum ferritin, TS, erythrocyte protoporphyrin, and C-reactive protein. Results: Mean sTfR and mean log sTfR:ferritin were ∼10% and 24% lower, respectively, in cases than in controls (P &lt;0.002). Cases were significantly more likely to have an sTfR value &lt;2.9 mg/L, the lower limit of the reference interval, than were controls (odds ratio = 1.8; 95% confidence interval, 1.04–2.37). Conclusion: Our results support previous studies that suggested that sTfR may be useful for assessing high iron status in populations.

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