scholarly journals Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age

2008 ◽  
Vol 100 (5) ◽  
pp. 1104-1108 ◽  
Author(s):  
Xiao-Ming Lin ◽  
Juan Zhang ◽  
Zhi-Yong Zou ◽  
Zhu Long ◽  
Wei Tian
Keyword(s):  
Roc Curve ◽  
Transferrin Receptor ◽  
Operating Characteristic ◽  
Significant Negative Correlation ◽  
Effective Rate ◽  
Fe Deficiency ◽  
Serum Transferrin ◽  
Diagnostic Efficacy ◽  
Serum Transferrin Receptor ◽  
Child Bearing

The objective was to study the evaluation of serum transferrin receptor (sTfR) for Fe deficiency in women of child-bearing age. Primary screening was performed in 942 women ranging in child-bearing age. Serum ferritin (SF), Zn protoporphyrin (ZPP) and Hb were determined. Then the subjects were divided into four groups: normal, Fe store depletion (IDs), Fe-deficiency erythropoiesis and Fe-deficiency anaemia. sTfR was determined and sTfR/SF (sTfR/logSF and log(sTfR/SF)) was calculated. Changes of sTfR in women of different Fe status were observed. A receiver-operating characteristic (ROC) curve was used to evaluate whether sTfR had proper diagnostic efficacy for functional Fe deficiency. The levels of sTfR increased significantly along with the aggravation of Fe deficiency. Increase of STfR/SF along with the aggravation of Fe deficiency was more significant than that of sTfR. STfR had a significant negative correlation with SF and Hb, while it had a significant positive correlation with ZPP. The ROC curve showed that the diagnostic effective rate of sTfR for Fe deficiency could reach 83 %. At this point, the sensitivity was 79 % and the specificity was 63 %. Log(sTfR/SF) could be considered to have the highest effective ratio in detecting IDs, since it reached 99 %. STfR and sTfR/SF could both reflect body Fe-deficiency status specifically. They could be used as reliable indicators for evaluating Fe status and diagnosing Fe deficiency in women of child-bearing age.

scholarly journals Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children

2006 ◽  
Vol 96 (6) ◽  
pp. 1134-1139 ◽  
Author(s):  
Xiao-Ming Lin ◽  
Cheng-Ye Ji ◽  
Wen-Jing Liu ◽  
Zhu Long ◽  
Xiao-Yi Shen
Keyword(s):  
Transferrin Receptor ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Fe Deficiency ◽  
Serum Transferrin ◽  
Diagnostic Efficacy ◽  
Republic Of China ◽  
Serum Transferrin Receptor ◽  
Before And After

The object of the present study was to investigate the levels of serum transferrin receptor (sTfR) and its response to Fe supplementation in Fe-deficient children and the role of sTfR in detecting Fe deficiency and assessing the efficacy of Fe supplementation. According to the diagnostic standard, 1006 children, aged 6–14 years in Fangshan district, Beijing, Peoples Republic of China, were divided into four groups: normal; Fe store depletion (IDs); Fe deficiency erythropoiesis (IDE); Fe deficiency anaemia (IDA). sTfR was determined and transferrin receptor-ferritin (TfR-F) index was calculated in 238 children, sixty-four normal and 174 Fe deficient. Children were administered a NaFeEDTA capsule containing 60 mg Fe once per week for the IDs and IDE groups and three times per week for the IDA group for nine consecutive weeks. The parameters reflecting Fe status and sTfR were determined before and after Fe supplementation. The levels of sTfR and TfR-F index in Fe-deficient children were significantly higher than those in the normal group. The receiver operating characteristic curve showed that sTfR has proper diagnostic efficacy for functional Fe deficiency. After Fe supplementation, the level of sTfR was significantly decreased in children with IDs, but not in children with IDE and IDA, while TfR-F index was significantly decreased in Fe-deficient children. sTfR is a reliable indicator for detecting functional Fe deficiency, and TfR-F index is a sensitive parameter for assessing the efficacy of Fe supplementation.

scholarly journals Soluble serum transferrin receptor and transferrin receptor-ferritin index in anemia of chronic kidney disease

2006 ◽  
Vol 35 (8) ◽  
pp. 520-543 ◽  
Author(s):  
Sandra Margetic ◽  
Elizabeta Topic ◽  
Andrea Tesija-Kuna ◽  
Ines Vukasovic
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

scholarly journals Erythroblastic Inclusions in Dominantly Inherited β Thalassemias

Blood ◽  
1997 ◽  
Vol 89 (1) ◽  
pp. 322-328 ◽  
Author(s):  
P. Joy Ho ◽  
Sunitha N. Wickramasinghe ◽  
David C. Rees ◽  
Matthew J. Lee ◽  
Ayed Eden ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Inclusion Bodies ◽  
Serum Transferrin ◽  
Mrna Transcript ◽  
Globin Chain ◽  
Prominent Feature ◽  
Ineffective Erythropoiesis ◽  
Serum Transferrin Receptor ◽  
Globin Chains ◽  
Cellular Pathology

While the precipitation of unstable variant β-globin chains has been implicated as a major pathogenic mechanism in dominantly inherited β thalassemia, their instability and presence in intra-erythroblastic inclusions have not been conclusively shown. We report the investigation of two cases of dominantly inherited β thalassemia due to heterozygosity for the β-codon 121 G-T mutation. In one case, we were able to demonstrate the presence of an abnormal β-globin chain in both peripheral blood reticulocytes and bone marrow erythroblasts, and to assess its stability in relation to the substantial amounts of mutant β mRNA transcript. The serum transferrin receptor (TfR) level was markedly increased, an indication of increased erythropoietic activity. In both cases, we could show by immunoelectron microscopy that the intra-erythroblastic inclusion bodies, a prominent feature of diseases in this category, contained not only precipitated α-globin chains, but also β chains. The data confirm previous suggestions that the cellular pathology underlying this group of β thalassemias is related to the synthesis of highly unstable β-globin chain variants, which fail to form functional tetramers and precipitate intracellularly with the concomitant excess α chains, leading to increased ineffective erythropoiesis.

scholarly journals Serum Transferrin Receptor Levels in Different Stages of Iron Deficiency

Blood ◽  
1997 ◽  
Vol 90 (3) ◽  
pp. 1332-1333
Author(s):  
E. Gimferrer ◽  
J. Ubeda ◽  
M.T. Royo ◽  
G.J. Marigó ◽  
N. Marco ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

EPO, red cells, and serum transferrin receptor in continuous and intermittent hypoxia

2000 ◽  
Vol 32 (4) ◽  
pp. 800-804 ◽  
Author(s):  
PENTTI O. KOISTINEN ◽  
HEIKKI RUSKO ◽  
KERTTU IRJALA ◽  
ALLAN RAJAM??KI ◽  
KENNETH PENTTINEN ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Intermittent Hypoxia ◽  
Red Cells ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

scholarly journals Increased Serum Transferrin Saturation Is Associated with Lower Serum Transferrin Receptor Concentration

1999 ◽  
Vol 45 (12) ◽  
pp. 2191-2199 ◽  
Author(s):  
Anne C Looker ◽  
Mark Loyevsky ◽  
Victor R Gordeuk
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Transferrin Receptor ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Reference Interval ◽  
Serum Transferrin ◽  
Reactive Protein ◽  
Serum Transferrin Receptor ◽  
Health And Nutrition

Abstract Background: Serum transferrin receptor (sTfR) concentrations are increased in iron deficiency. We wished to examine whether they are decreased in the presence of potential iron-loading conditions, as reflected by increased transferrin saturation (TS) on a single occasion. Methods: We compared sTfR concentrations between 570 controls with normal iron status and 189 cases with increased serum TS on a single occasion; these latter individuals may be potential cases of iron overload. Cases and controls were selected from adults who had been examined in the third National Health and Nutrition Examination Survey (1988–1994) and for whom excess sera were available to perform sTfR measurements after the survey’s completion. Increased TS was defined as >60% for men and >55% for women; normal iron status was defined as having no evidence of iron deficiency, iron overload, or inflammation indicated by serum ferritin, TS, erythrocyte protoporphyrin, and C-reactive protein. Results: Mean sTfR and mean log sTfR:ferritin were ∼10% and 24% lower, respectively, in cases than in controls (P <0.002). Cases were significantly more likely to have an sTfR value <2.9 mg/L, the lower limit of the reference interval, than were controls (odds ratio = 1.8; 95% confidence interval, 1.04–2.37). Conclusion: Our results support previous studies that suggested that sTfR may be useful for assessing high iron status in populations.

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