Animal models for sleep disorders

2009 ◽  
pp. 504-543
Author(s):  
Seiji Nishino ◽  
Nobuhiro Fujiki
Keyword(s):  
Animal Models ◽  
Sleep Disorders

Herbal medicinal products as an alternative for the treatment of minor sleep disorders and mild anxiety symptoms? Proof of concept in animal models

2014 ◽  
Vol 29 (S3) ◽  
pp. 657-657
Author(s):  
I. Heulard ◽  
M. Verleye
Keyword(s):  
Animal Models ◽  
Sleep Disorders ◽  
Sedative Effect ◽  
Anxiety Symptoms ◽  
Medicinal Products ◽  
Melissa Officinalis ◽  
General Activity ◽  
Herbal Medicinal Products ◽  
Herbal Medicinal ◽  
Dose Dependent

Herbal medicinal products have been traditionally used for the treatment of minor sleep disorders and mild anxiety symptoms. However, prospective clinical studies are scarce, due to a number of variability factors such as population heterogeneity and a strong placebo effect. To overcome these limitations, animal models are available that provide unbiased scientific results.In this study, we examined the effect of an association of four compounds [namely Melissa officinalis, Crataegus oxyancantha, calcium lactate and magnesium thiosulfate (32/30/32/6; w/w)], on several behavioral tests in rodents. Animals were tested for general activity on an automated actimetry system, and for anxiety on the so-called “staircase test”.In the actimetry test, adult mice were placed in an empty cage and their spontaneous level of activity (distance travelled and the number of rearings) was measured after an intraperitoneal administration of 25, 50 or 75 mg/kg of the association. A dose-dependent decrease of the distance travelled and number of rearings was observed after administration (statistically significant at the dose of 75 mg/kg). In the staircase test, the number of rearings (a measure of anxiety) and the number of steps climbed (general activity) were measured. A statistically significant decrease in the number of rearings was observed at the dose of 25 mg/kg (compared to vehicle-treated animals), whereas no effect in the number of steps climbed was observed at the same dose. These results suggest that the association could induce an anxiolytic effect. At higher doses, a sedative effect was observed.In conclusion, the administration of an association of Melissa officinalis, Crataegus oxyacantha, calcium and magnesium induced a clear dose-dependent sedative effect in mice. One test suggests that this association could also have anxiolytic properties. This study confirms that herbal medicinal products could be a beneficial treatment for minor sleep disorders or mild anxiety symptoms.

Sleep disorders in Prader-Willi syndrome, evidence from animal models and humans

2021 ◽  
Vol 57 ◽  
pp. 101432
Author(s):  
Matteo Cataldi ◽  
Dario Arnaldi ◽  
Valter Tucci ◽  
Fabrizio De Carli ◽  
Giuseppa Patti ◽  
...  
Keyword(s):  
Animal Models ◽  
Sleep Disorders ◽  
Prader Willi Syndrome

scholarly journals Defining and measuring paradoxical (REM) sleep in animal models of sleep disorders

2020 ◽  
Vol 15 ◽  
pp. 203-209
Author(s):  
Christelle Peyron ◽  
Sébastien Arthaud ◽  
Manon Villalba ◽  
Patrice Fort
Keyword(s):  
Animal Models ◽  
Sleep Disorders ◽  
Rem Sleep

scholarly journals Sleep Disorders in Children With Autism Spectrum Disorder: Insights From Animal Models, Especially Non-human Primate Model

2021 ◽  
Vol 15 ◽  
Author(s):  
Shufei Feng ◽  
Haoyu Huang ◽  
Na Wang ◽  
Yuanyuan Wei ◽  
Yun Liu ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Animal Models ◽  
Sleep Disorders ◽  
Sleep Problems ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Children With Asd ◽  
Human Primate

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder with deficient social skills, communication deficits and repetitive behaviors. The prevalence of ASD has increased among children in recent years. Children with ASD experience more sleep problems, and sleep appears to be essential for the survival and integrity of most living organisms, especially for typical synaptic development and brain plasticity. Many methods have been used to assess sleep problems over past decades such as sleep diaries and parent-reported questionnaires, electroencephalography, actigraphy and videosomnography. A substantial number of rodent and non-human primate models of ASD have been generated. Many of these animal models exhibited sleep disorders at an early age. The aim of this review is to examine and discuss sleep disorders in children with ASD. Toward this aim, we evaluated the prevalence, clinical characteristics, phenotypic analyses, and pathophysiological brain mechanisms of ASD. We highlight the current state of animal models for ASD and explore their implications and prospects for investigating sleep disorders associated with ASD.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

435 Heart failure and sleep disorders breathing: 61 consecutive subjects

2006 ◽  
Vol 5 (1) ◽  
pp. 103-103
Author(s):  
D CORONE ◽  
C DARNE ◽  
T FARROKHI ◽  
A HATTAB ◽  
S HARDY ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sleep Disorders

Inflammational Animal Models for Schizophrenia

2015 ◽  
Vol 223 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Georg Juckel
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Immune Activation ◽  
Microglial Activation ◽  
Treatment Options ◽  
Early Adulthood ◽  
Brain Regions ◽  
Synaptic Connections ◽  
Preventive Interventions ◽  
Immunological System

Abstract. Inflammational-immunological processes within the pathophysiology of schizophrenia seem to play an important role. Early signals of neurobiological changes in the embryonal phase of brain in later patients with schizophrenia might lead to activation of the immunological system, for example, of cytokines and microglial cells. Microglia then induces – via the neurotoxic activities of these cells as an overreaction – a rarification of synaptic connections in frontal and temporal brain regions, that is, reduction of the neuropil. Promising inflammational animal models for schizophrenia with high validity can be used today to mimic behavioral as well as neurobiological findings in patients, for example, the well-known neurochemical alterations of dopaminergic, glutamatergic, serotonergic, and other neurotransmitter systems. Also the microglial activation can be modeled well within one of this models, that is, the inflammational PolyI:C animal model of schizophrenia, showing a time peak in late adolescence/early adulthood. The exact mechanism, by which activated microglia cells then triggers further neurodegeneration, must now be investigated in broader detail. Thus, these animal models can be used to understand the pathophysiology of schizophrenia better especially concerning the interaction of immune activation, inflammation, and neurodegeneration. This could also lead to the development of anti-inflammational treatment options and of preventive interventions.

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