Genetics of human susceptibility to infection and hepatic disease caused by schistosomes

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Download Full-text

Total Solids, Fat and Nitrogen in the Feces: V. A Study of Patients With Primary Parenchymatous Hepatic Disease

Gastroenterology ◽

10.1016/s0016-5085(19)36600-4 ◽

1950 ◽

Vol 16 (1) ◽

pp. 140-150 ◽

Cited By ~ 30

Author(s):

John B. Gross ◽

Mandred W. Comfort ◽

Eric E. Wollaeger ◽

Marschelle H. Power

Keyword(s):

Hepatic Disease ◽

Total Solids

Download Full-text

The Use of Prednisone to Initiate or Potentiate Diuresis in Chronic Hepatic Disease with Ascites

Gastroenterology ◽

10.1016/s0016-5085(60)80117-5 ◽

1960 ◽

Vol 38 (1) ◽

pp. 52-59 ◽

Cited By ~ 8

Author(s):

John V. Carbone ◽

H.B. Matthews

Keyword(s):

Hepatic Disease ◽

Chronic Hepatic Disease

Download Full-text

Anemia of Hepatic Disease Studied with Radiochromium

Gastroenterology ◽

10.1016/s0016-5085(60)80134-5 ◽

1960 ◽

Vol 38 (3) ◽

pp. 324-331 ◽

Cited By ~ 32

Author(s):

Madison J. Cawein ◽

Albert B. Hagedorn ◽

Charles A. Owen

Keyword(s):

Hepatic Disease

Download Full-text

The Origin of Elevation of Serum Alkaline Phosphatase in Hepatic Disease

Gastroenterology ◽

10.1016/s0016-5085(62)80053-5 ◽

1962 ◽

Vol 42 (4) ◽

pp. 431-438 ◽

Cited By ~ 49

Author(s):

Stanton G. Polin ◽

Mitchell A. Spellberg ◽

Lloyd Teitelman ◽

Makoto Okumura

Keyword(s):

Alkaline Phosphatase ◽

Serum Alkaline Phosphatase ◽

Hepatic Disease

Download Full-text

RESPONSES OF PLANTS TO INFECTION BY BOTRYTIS CINEREA AND NOVEL MEANS INVOLVED IN REDUCING THEIR SUSCEPTIBILITY TO INFECTION

Biological Reviews of the Cambridge Philosophical Society ◽

10.1017/s0006323197005057 ◽

1997 ◽

Vol 72 (3) ◽

pp. 381-422 ◽

Cited By ~ 64

Author(s):

Y. ELAD

Keyword(s):

Botrytis Cinerea ◽

Susceptibility To Infection

Download Full-text

Sonography of subcutaneous tissue cannot determine causes of lower limb edema

VASA ◽

10.1024/0301-1526/a000418 ◽

2015 ◽

Vol 44 (2) ◽

pp. 122-128 ◽

Cited By ~ 6

Author(s):

Mandy Becker ◽

Tom Schilling ◽

Olga von Beckerath ◽

Knut Kröger

Keyword(s):

Clinical Diagnosis ◽

Lower Limb ◽

Subcutaneous Tissue ◽

Hepatic Disease ◽

Clinical Use ◽

Single Image ◽

Heart Insufficiency ◽

Chronic Hepatic Disease ◽

Limb Edema ◽

Venous Disorders

Background: To clarify the clinical use of sonography for differentiation of edema we tried to answer the question whether a group of doctors can differentiate lymphedema from cardiac, hepatic or venous edema just by analysing sonographic images of the edema. Patients and methods: 38 (70 ± 12 years, 22 (58 %) females) patients with lower limb edema were recruited according the clinical diagnosis: 10 (26 %) lymphedema, 16 (42 %) heart insufficiency, 6 (16 %) venous disorders, 6 (16 %) chronic hepatic disease. Edema was depicted sonographically at the most affected leg in a standardised way at distal and proximal calf. 38 sets of images were anonymised and send to 5 experienced doctors. They were asked whether they can see criteria for lymphedema: 1. anechoic gaps, 2. horizontal gaps and 3. echoic rims. Results: Accepting an edema as lymphedema if only one doctor sees at least one of the three criteria for lymphatic edema on each single image all edema would be classified as lymphatic. Accepting lymphedema only if all doctors see at least one of the three criteria on the distal image of the same patient 80 % of the patients supposed to have lymphedema are classified as such, but also the majority of cardiac, venous and hepatic edema. Accepting lymphedema only if all doctors see all three criteria on the distal image of the same patients no edema would be classified as lymphatic. In addition we separated patients by Stemmers sign in those with positive and negative sign. The interpretation of the images was not different between both groups. Conclusions: Our analysis shows that it is not possible to differentiate lymphedema from other lower limb edema sonographically.

Download Full-text

Liver Tests Often Miss Hepatic Disease in Type 2 Diabetes

Family Practice News ◽

10.1016/s0300-7073(11)70920-3 ◽

2011 ◽

Vol 41 (17) ◽

pp. 53

Author(s):

SARA FREEMAN

Keyword(s):

Type 2 Diabetes ◽

Hepatic Disease ◽

Liver Tests

Download Full-text

Gene Polymorphisms and Their Association to Coronavirus Family Infections: Susceptibility in Different Populations

Medical & Clinical Research ◽

10.33140/mcr.05.012 ◽

2020 ◽

Vol 5 ◽

Keyword(s):

Genetic Variants ◽

Viral Infections ◽

Human Leukocyte ◽

Asian Population ◽

African Region ◽

Mediterranean Populations ◽

Susceptibility To Infection ◽

Asian Populations ◽

Spread Pattern ◽

Different Populations

Human leukocyte antigen (HLA) loci are highly polymorphic and determine differential features of the immune response in subjects from different regions. HLA genes have been proposed to determine genetic susceptibility to several diseases, particularly to viral infections. Moreover, it has been suggested that each ethnic group could have a different specificity of T-lymphocyte reactivity to the same viral infections. In this review, we analyzed the distribution of HLA types in countries of the Asian, European and North African region. Also, we studied the relation between these HLA polymorphisms and susceptibility to infection by the coronavirus. Our findings indicated that homozygosity would increase susceptibility to viral infections and, in some cases, to coronavirus infection. HLA types showing higher susceptibility were reported in Asian population, including China, Singapore, and Taiwan. In contrast, lower susceptibility HLA variants were detected among African populations, some Asian populations, and Mediterranean populations. The presented evidence along with the spread pattern of COVID-19 infection suggests that HLA genetic variants might be related to its infection susceptibility and severity. The investigation of HLA genetic variants distribution would be a useful tool to predict different populations’ susceptibility to viral infections.

Download Full-text