Effect of Intranasal Mupirocin Prophylaxis on Methicillin-Resistant Staphylococcus aureus Transmission and Invasive Staphylococcal Infections in a Neonatal Intensive Care Unit

2018 ◽  
Vol 39 (6) ◽  
pp. 741-745 ◽  
Author(s):  
Elizabeth H. Ristagno ◽  
Kristina A. Bryant ◽  
Lynette F. Boland ◽  
Gordon G. Stout ◽  
Alan D. Junkins ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Staphylococcus Aureus ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Invasive Infection ◽  
Methicillin Resistant ◽  
Intranasal Mupirocin ◽  
Over Time

The use of monthly intranasal mupirocin was associated with a significant reduction in the rate of methicillin-resistant Staphylococcus aureus transmission and Staphylococcus aureus invasive infection in a large neonatal intensive care unit. Resistance to mupirocin emerged over time, but it was rare and was not associated with adverse clinical outcomes.Infect Control Hosp Epidemiol 2018;39:741–745

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