Discordant Twins: Acid-Base Status

1991 ◽  
Vol 40 (3-4) ◽  
pp. 373-381 ◽  
Author(s):  
S.A. Ordorica ◽  
F.J. Frieden ◽  
I.A. Hoskins ◽  
B.K. Young

AbstractA prospective study was undertaken to determine the effect of twin birth-weight discordancy on Apgar scores and umbilical blood acid-base parameters. Using the paired t-test, small but statistically significant differences were seen in these parameters favoring the heavier twin over its lighter sibling. These differences were also affected by birth order, with the first-born being favored.

2013 ◽  
Vol 304 (10) ◽  
pp. R908-R916 ◽  
Author(s):  
Dan Rurak ◽  
Natalee W. Bessette

To determine whether there are changes in blood gas and acid-base status with advancing gestation in the fetal lamb, similar to that reported in the human fetus, blood gas, acid-base, and blood metabolite values were measured in 447 control, arterial blood samples from 108 chronically instrumented fetal lambs between 103 and 146 days gestation. With advancing gestation, Po2, pH, O2saturation, and O2content fell significantly, while Pco2and hemoglobin concentration increased. Blood glucose and lactate concentrations were unchanged, although the lactate level increased with decreasing Po2, particularly when below ∼13 mmHg. Multiple linear regression indicated that increasing fetal number was associated with decreased Po2and glucose level and increased pH, HCO3−, base excess, and lactate concentration. Hemoglobin concentration was higher in female than male lambs. Overall, there was a linear relationship between glucose concentration and birth weight. It is concluded that in fetal lambs as in the human fetus, there are changes in blood gas and acid-base status with advancing gestation. This may be due to the decrease in fetal weight-normalized uterine and umbilical blood flows than occurs in these and other species as gestation proceeds. In addition, the reduced birth weight in twin and triplet lambs may be due to hypoglycemia rather than hypoxemia.


1980 ◽  
Vol 229 (1) ◽  
pp. 45-55 ◽  
Author(s):  
K. H. Breuker ◽  
I. Kriebel ◽  
W. Haase ◽  
A. Bolte

1995 ◽  
Vol 39 (3) ◽  
pp. 150
Author(s):  
M. L. SOCOL ◽  
P. M. GARCIA ◽  
S. RITER

1994 ◽  
Vol 170 (4) ◽  
pp. 991-999 ◽  
Author(s):  
Michael L. Socol ◽  
Patricia M. Garcia ◽  
Susan Riter

1986 ◽  
Vol 6 (4) ◽  
pp. 306-307
Author(s):  
F. O. Page ◽  
J. N. Martin ◽  
S. M. Palmer ◽  
R. W. Martin ◽  
J. A. Lucas ◽  
...  

Author(s):  
Therese K. Abboud ◽  
Michael J. Moore ◽  
Jerry Jacobs ◽  
Kazushige Murakawa ◽  
Manoutchehr Soraya ◽  
...  

The effects of epidural anesthesia using mepivacaine on maternal blood pressure, newborn Apgar scores, neonatal acid-base status, and the Early Neonatal Neurobehavioral Scale (ENNS) were studied in 21 pregnant women undergoing cesarean section. Maternal and neonatal blood levels of mepivacaine were also determined. Neonatal outcome was compared with a control group of 14 neonates of healthy mothers who received 3% 2-chloroprocaine for elective cesarean section. All patients had satisfactory anesthesia for cesarean section with an onset of 19 ± 1.8 minutes (mean ± SEM) and duration of 95 ± 11.9 minutes. Hypotension developed in two patients, and they were treated with intravenous ephedrine. All neonates had Apgar scores of 8 or more at 1 and 5 minutes and normal blood gases and acid-base status. None of the variables of the ENNS differed significantly between the mepivacaine and the chloroprocaine control group with the exception of truncal tone, which was significantly higher in the mepivacaine group ( p < 0.05). Mepivacaine was detected in all maternal and fetal samples, and the umbilical venous to maternal venous ratio was 0.57 ± 0.17 (mean ± SEM).


2015 ◽  
Vol 38 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Jos� Morales-Rosell� ◽  
Asma Khalil ◽  
Jos� Alberola-Rubio ◽  
David Hervas-Mar�n ◽  
Maddalena Morlando ◽  
...  

1996 ◽  
Vol 87 (2) ◽  
pp. 175-180 ◽  
Author(s):  
FRANCISCO L. GAUDIER ◽  
ROBERT L. GOLDENBERG ◽  
KATHLEEN G. NELSON ◽  
MYRIAM PERALTA–CARCELEN ◽  
MARY B. DuBARD ◽  
...  

1989 ◽  
Vol 67 (12) ◽  
pp. 3005-3017 ◽  
Author(s):  
Hans-Otto Pörtner

Metabolism not only affects the acid–base status of an animal by means of proton stoichiometries but, by feedback regulation, acid–base parameters (pH, [Formula: see text], bicarbonate) influence metabolic rates and the pathways used. This leads to a significant contribution of metabolism to acid–base regulation under both aerobic and anaerobic conditions. The relationship between amino acid metabolism, urea synthesis, and [Formula: see text] excretion is discussed as an example important for steady-state metabolic acid–base regulation during aerobiosis. Generally, acid–base relevant metabolism may be regulated through the effect of acid–base disturbances on hormonal mediation, allosteric modulation of enzyme proteins, pH optima, and the levels of substrates or products, some of these being acid–base relevant substances like bicarbonate, CO2, inorganic phosphate, and NH3. During functional or environmental anaerobiosis the same relationships prevail. Metabolic proton accumulation is counterbalanced by phosphagen depletion and ammonia accumulation in adenylate catabolism. In addition, in integrated control of metabolic and acid–base status, long-term (mitochondrial) anaerobiosis leads to reductions in metabolic rate and increased removal of acidic groups. The importance of metabolic processes in acid–base methodology is discussed in terms of traditional concepts and recent developments.


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