A Family Study of Developmental Effects upon Blood Pressure Variation

1987 ◽  
Vol 36 (4) ◽  
pp. 467-473 ◽  
Author(s):  
J. Sims ◽  
D. Carroll ◽  
J.K. Hewitt ◽  
J.R. Turner
Keyword(s):  
Blood Pressure ◽  
Family Study ◽  
Model Fitting ◽  
Pressure Variation ◽  
Age Group ◽  
Developmental Effects ◽  
Blood Pressure Variation ◽  
Likelihood Model ◽  
Salient Factor ◽  
The Impact

AbstractIn an earlier study of blood pressure variation in middle aged parents and their young adult twin offspring, the greater blood pressure variation observed in the parent sample was accounted for in terms of an increasing influence of individual environmental experiences with increasing age and a commensurate reduction in the impact of heredity. In the present study, the sample size was enlarged to provide a more powerful test of these effects. Maximum likelihood model-fitting techniques were applied to blood pressure covariation in balanced pedigrees, consisting of 85 families (40 MZ and 45 DZ twin pairs). As before, our analysis indicated that a developmental effect was a salient factor in the older age group.

Familial and Individual Influences on Blood Pressure

1986 ◽  
Vol 35 (1-2) ◽  
pp. 7-21 ◽  
Author(s):  
J. Sims ◽  
J.K. Hewitt ◽  
K.A. Kelly ◽  
D. Carroll ◽  
J.R. Turner
Keyword(s):  
Blood Pressure ◽  
Young Adult ◽  
Family Study ◽  
Middle Age ◽  
Familial Aggregation ◽  
Model Fitting ◽  
Developmental Changes ◽  
Present Sample ◽  
Likelihood Model ◽  
Apparent Reduction

AbstractAlthough familial aggregation of blood pressure is well documented, few studies have considered the changing contribution of genetic and environmental influences during adulthood. Applying maximum likelihood model fitting to blood pressure covariation in balanced pedigrees including both parents and their young adult twin offsprings (25 MZ, 32 DZ, aged between 16 and 24 years), it is shown that the increased variation in parents is explained by such developmental changes. For DBP, an apparent reduction in heritability from 68% to 38% from young adulthood to middle age results from the increasing impact of individual environmental experience (E1), with little or no influence from shared family environmental (E2). For SBP, shared environmental effects may play a part. Given the relatively small size of the present sample, the conclusions are to be seen as tentative. An augmented family study, incorporating middle aged twins and their young adult offspring, will clarify the causation of these developmental changes.

scholarly journals The impact of intraoperative blood pressure variability on the risk of postoperative adverse outcomes in non-cardiac surgery: a systematic review

2022 ◽  
Author(s):  
Zbigniew Putowski ◽  
Marcelina Czok ◽  
Łukasz J. Krzych
Keyword(s):  
Blood Pressure ◽  
Cardiac Surgery ◽  
Postoperative Complications ◽  
Blood Pressure Variability ◽  
Pressure Variation ◽  
Adverse Outcomes ◽  
Cochrane Library ◽  
Medical Subject Headings ◽  
Blood Pressure Variation ◽  
The Impact

AbstractHemodynamic stability during surgery seems to account for positive postoperative outcomes in patients. However, little is known about the impact of intraoperative blood pressure variability (IBPV) on the postoperative complications. The aim was to investigate whether IBPV is associated with the development of postoperative complications and what is the nature of this association. We conducted a systematic search in PubMed, Medical Subject Headings, Embase, Web of Science, SCOPUS, clinicaltrials.gov, and Cochrane Library on the 8th of April, 2021. We included studies that only focused on adults who underwent primarily elective, non-cardiac surgery in which intraoperative blood pressure variation was measured and analyzed in regard to postoperative, non-surgical complications. We identified 11 papers. The studies varied in terms of applied definitions of blood pressure variation, of which standard deviation and average real variability were the most commonly applied definitions. Among the studies, the most consistent analyzed outcome was a 30-day mortality. The studies presented highly heterogeneous results, even after taking into account only the studies of best quality. Both higher and lower IBPV were reported to be associated for postoperative complications. Based on a limited number of studies, IBPV does not seem to be a reliable indicator in predicting postoperative complications. Existing premises suggest that either higher or lower IBPV could contribute to postoperative complications. Taking into account the heterogeneity and quality of the studies, the conclusions may not be definitive.

Diurnal Blood Pressure Variation in Quadriplegic Chronic Spinal Cord Injury Patients

1991 ◽  
Vol 80 (3) ◽  
pp. 271-276 ◽  
Author(s):  
Henry Krum ◽  
William J. Louis ◽  
Douglas J. Brown ◽  
Graham P. Jackman ◽  
Laurence G. Howes
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Heart Rate ◽  
Spinal Cord Injury ◽  
Ambulatory Monitoring ◽  
Pressure Variation ◽  
Night Time ◽  
Cord Injury ◽  
Blood Pressure Variation ◽  
Neurologically Intact

1. Measurement of blood pressure and heart rate over a 24 h period was peformed in 10 quadriplegic spinal cord injury patients and 10 immobilized, neurologically intact orthopaedic subjects by using the Spacelabs 90207 automated ambulatory monitoring system. 2. Systolic and diastolic blood pressure fell significantly at night in orthopaedic subjects but not in quadriplegic patients, and night-time blood pressures were similar in both groups. 3. Cumulative summation of differences from a reference value (cusum analysis) confirmed a markedly diminished diurnal blood pressure variation in the quadriplegic patients. 4. These findings could not be accounted for on the basis of blood pressure variations during chronic postural change. 5. Heart rate fell significantly at night in both groups. 6. The findings suggest that the increase in blood pressure during waking hours in neurologically intact subjects is a consequence of a diurnal variation in sympathetic activity (absent in quadriplegic patients with sympathetic decentralization) which is independent of changes in physical activity.

scholarly journals Association of Sixty-One Non-Synonymous Polymorphisms in Forty-One Hypertension Candidate Genes with Blood Pressure Variation and Hypertension

2006 ◽  
Vol 29 (8) ◽  
pp. 611-619 ◽  
Author(s):  
Yoshihiro KOKUBO ◽  
Hitonobu TOMOIKE ◽  
Chihiro TANAKA ◽  
Mariko BANNO ◽  
Tomohiko OKUDA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Candidate Genes ◽  
Pressure Variation ◽  
Blood Pressure Variation

scholarly journals Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry

2017 ◽  
Vol 35 (7) ◽  
pp. 1381-1389 ◽  
Author(s):  
Priyanka Nandakumar ◽  
Dongwon Lee ◽  
Melissa A. Richard ◽  
Fasil Tekola-Ayele ◽  
Bamidele O. Tayo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
African Ancestry ◽  
Pressure Variation ◽  
Blood Pressure Variation ◽  
Coding Variants
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