Immunological Studies on Experimental Infection of Pigs with Ascaris suum Goeze, 1782. IV. The Primary Antibody Response

1964 ◽  
Vol 38 (1-2) ◽  
pp. 151-158 ◽  
Author(s):  
L. F. Taffs
Keyword(s):  
Antibody Response ◽  
Experimental Infection ◽  
Serum Antibody ◽  
Test Dose ◽  
Primary Antibody ◽  
Critical Study ◽  
Acquired Immunity ◽  
Absorption Test ◽  
Saline Extract ◽  
Primary Antibody Response

It was possible to make a more critical study of immunity against A. suum by infecting pathogen-free, colostrum-deprived pigs produced by hysterectomy.By means of the conglutinating complement absorption test, using a saline extract of worm as antigen, antibodies were first demonstrated in the circulation of three experimentally-infected pigs between the 10th and 13th days of infection, and were detected in the sera of two of them for at least 97 days.The infections did not become patent, and no acquired immunity was shown by the pigs against a reinfection 97 days later. There was no evidence of an age immunity against migrant larvae.A rise in serum antibody was observed, within seven days of infection, in six pigs aged between 10 weeks and 11 months, following a test dose of 500,000 eggs. Three suckling pigs, aged three weeks, did not respond serologically within seven days to the same test dose.

Immunological Studies on Experimental Infection of Pigs with Ascaris suum Goeze, 1782. III.—The Antibody Response and Acquired Immunity

1964 ◽  
Vol 38 (1-2) ◽  
pp. 129-150 ◽  
Author(s):  
L. F. Taffs
Keyword(s):  
Antibody Response ◽  
Experimental Infection ◽  
Larval Growth ◽  
Clinical Signs ◽  
Acquired Immunity ◽  
Absorption Test ◽  
Challenge Dose ◽  
Larval Migration ◽  
Antibody Titres ◽  
Two Peaks

Two experiments are described in which antibodies against A. suum were detected in the circulation of infected pigs by means of the conglutinating complement absorption test. The pattern and nature of the antibody response was studied. In 21 out of 24 cases the sera antibody titres rose after test doses of infective eggs were given, and on 18 of these occasions a rise in titre was observed within seven days. Following infection two peaks of antibody were detected. At three to four weeks the antibody content of the serum reached its highest concentration, and a further rise was apparent between the 37th and 56th days.The phenomenon of “self-cure” was demonstrated following reinfection. This was manifested by a depression of the egg count and the elimination of Ascaris worms from the intestine, with a concomitant rise in the antibody content of the serum.In three out of five pigs which were initially infected, the infection became patent between the 51st and 58th days. On only one occasion out of thirteen were any superimposed larvae able to reach maturity.Pigs which had been previously infected exhibited resistance to a challenge dose. This was shown by (1) the absence of clinical signs, (2) a resistance to larval migration, and (3) an inhibition of larval growth. In this demonstration of an active acquired immunity to A. suum infection in pigs, a correlation between resistance and high sera titres was observed.

Effect of stress and other biopsychosocial factors on primary antibody response

1990 ◽  
Vol 11 (6) ◽  
pp. 472-479 ◽  
Author(s):  
Barbara K. Snyder ◽  
Klaus J. Roghmann ◽  
Leonard H. Sigal
Keyword(s):  
Antibody Response ◽  
Primary Antibody ◽  
Primary Antibody Response
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