Malignant fibrous histiocytoma of the nasopharynx

AbstractMalignant Fibrous Histiocytomas (MFH) are uncommon in the head and neck and extremely rare in the nasopharynx. We report a case of MFH arising in the nasopharynx and describe its diagnosis and management. The literature is reviewed and the likely origins of the tumour and its behaviour are discussed.

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Malignant Fibrous Histiocytoma in Dogs and Cats

Veterinary Pathology ◽

10.1177/030098587901600205 ◽

1979 ◽

Vol 16 (2) ◽

pp. 199-208 ◽

Cited By ~ 26

Author(s):

C. A. Gleiser ◽

G. L. Raulston ◽

J. H. Jardine ◽

K. N. Gray

Keyword(s):

Soft Tissue ◽

Giant Cell ◽

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Soft Tissue Tumors ◽

Fibrous Histiocytomas ◽

Malignant Fibrous Histiocytomas ◽

Multinucleated Cells ◽

Cell Variant ◽

And Function

Five soft tissue tumors of varied morphology in dogs and cats were classified as malignant fibrous histiocytomas on the basis of their histologic composition. All were composed of varying mixtures of histiocytes and fibroblasts and three contained large multinucleated cells. This giant cell variant of malignant fibrous histiocytoma was seen only in cats. These tumors are comparable to those described in man as malignant fibrous histiocytoma on the basis of the malignant histiocyte and its varied morphology and function.

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MASL1: a neglected ROCO protein

Biochemical Society Transactions ◽

10.1042/bst20120127 ◽

2012 ◽

Vol 40 (5) ◽

pp. 1090-1094 ◽

Cited By ~ 12

Author(s):

Sybille Dihanich

Keyword(s):

Parkinson’S Disease ◽

Malignant Fibrous Histiocytoma ◽

Tandem Repeats ◽

Fibrous Histiocytoma ◽

Present Review ◽

Research Focus ◽

Gtpase Domain ◽

Fibrous Histiocytomas ◽

Malignant Fibrous Histiocytomas ◽

Lack Of Information

The human ROCO proteins are a family of four proteins characterized by a conserved supradomain: a Ras-like GTPase domain. This domain consists of ROC (Ras of complex proteins) occurring in tandem with a COR (C-terminal of ROC) domain. Together, these proteins are linked to various pathologies including cancer and PD (Parkinson's disease). Despite an increasing research focus on these proteins, their functions in general, and their specific roles in disease, are still unknown. In the case of MASL1 (malignant fibrous histiocytoma amplified sequences with leucine-rich tandem repeats 1), a predicted oncoprotein in MFHs (malignant fibrous histiocytomas), there is a particular lack of information available in the literature. The aim of the present review is therefore to summarize the existing information on MASL1 and also to compile data that could be linked to MASL1 and thus help our understanding of this neglected ROCO protein.

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Head and Neck Malignant Fibrous Histiocytomas

Ear Nose & Throat Journal ◽

10.1177/014556139307200414 ◽

1993 ◽

Vol 72 (4) ◽

pp. 299-302 ◽

Cited By ~ 6

Author(s):

Robert Sawyer ◽

David L. Webb ◽

Donald J. Wittich

Keyword(s):

Radiation Therapy ◽

Head And Neck ◽

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Surgical Excision ◽

Rare Tumor ◽

Traditional Treatment ◽

Fibrous Histiocytomas ◽

Difficult Diagnosis ◽

Aggressive Tumors

Malignant fibrous histiocytoma of the head and neck is a rare tumor with less than 50 total cases reported in the literature. Its rarity and complex histopathology combine to make it a difficult diagnosis. Two cases are described. Pathology characteristics are discussed. The traditional treatment of choice is wide surgical excision. Radiation therapy is usually reserved for recurrent, unresectable, or extremely aggressive tumors.

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β-Catenin Accumulation and Gene Mutation in Exon 3 in Dedifferentiated Liposarcoma and Malignant Fibrous Histiocytoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2002-126-1071-caagmi ◽

2002 ◽

Vol 126 (9) ◽

pp. 1071-1078 ◽

Cited By ~ 6

Author(s):

Akio Sakamoto ◽

Yoshinao Oda ◽

Toshisada Adachi ◽

Tsuyoshi Saito ◽

Sadafumi Tamiya ◽

...

Keyword(s):

Cell Proliferation ◽

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Labeling Index ◽

Sequencing Analysis ◽

Tumor Type ◽

Fibrous Histiocytomas ◽

Malignant Fibrous Histiocytomas ◽

Well Differentiated ◽

Mib 1

Abstract Context.—β-Catenin is an adhesion molecule that also plays a role in the Wnt signaling pathway. Objective.—To analyze β-catenin mutation and accumulation in a series of liposarcomas and malignant fibrous histiocytomas. Design.—β-Catenin mutation in exon 3 was studied using polymerase chain reaction–single-strand conformation polymorphism (PCR-SSCP) and direct sequencing analysis in 30 formalin-fixed, paraffin-embedded liposarcomas. The tumors included 12 dedifferentiated liposarcomas, characterized by both high-grade anaplastic components and well-differentiated liposarcoma components, plus 18 well-differentiated liposarcomas (10 lipoma-like and 8 sclerosing-type cases). The 2 components of dedifferentiated liposarcomas were analyzed independently. β-Catenin accumulation in the nuclei or cytoplasm and Ki-67 expression (cell-proliferation marker, MIB-1 labeling index) were examined immunohistochemically. Nine storiform-pleomorphic–type malignant fibrous histiocytomas were also studied. Results.—Dedifferentiated liposarcomas showed mutation in 2 cases (17%) and accumulation in 5 cases (42%). One of the 2 cases that showed mutations had a mutation in the well-differentiated component; this mutation was silent. The other case had mutations that differed between the 2 components. In well-differentiated liposarcomas, mutation was not seen in any of the cases (0/18; 0%); however, accumulation was seen frequently in the sclerosing-type cases (5/8; 63%), but not in the lipoma-like cases (0/10; 0%). Malignant fibrous histiocytomas showed mutation and accumulation in 5 (56%) and 4 (44%) cases, respectively, without any exact correlation between the cases. Cases with accumulation had a higher MIB-1 labeling index than those without, among both the sclerosing-type well-differentiated liposarcomas (P < .05) and the malignant fibrous histiocytomas. Conclusions.—Our results suggest the possible involvement of β-catenin activation caused by β-catenin mutation in liposarcoma and malignant fibrous histiocytoma, but the contribution would seem to be different, depending on the tumor type. β-Catenin accumulation is also thought to be related to cell proliferation in some of the cases.

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Primary giant cell malignant fibrous histiocytoma-associated with renal calculus

Canadian Urological Association Journal ◽

10.5489/cuaj.1485 ◽

2014 ◽

Vol 8 (3-4) ◽

pp. 193 ◽

Cited By ~ 3

Author(s):

Adem Altunkol ◽

Murat Savas ◽

Halil Ciftci ◽

Mehmet Gulum ◽

Ismail Yagmur ◽

...

Keyword(s):

Case Report ◽

Soft Tissue ◽

Giant Cell ◽

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Soft Tissue Sarcomas ◽

Renal Calculus ◽

Fibrous Histiocytomas ◽

Malignant Fibrous Histiocytomas ◽

Visceral Organs

Malignant fibrous histiocytomas (MFH) are the most commonly seen soft tissue sarcomas in adults. It is rarely seen in some visceral organs. Kidneys are the parenchymal organs in which MFHs are most frequently seen. More than 50 cases of primary renal MFH have been reported. Among these cases, only 1 was reported as primary giant cell subtype in association with urolithiasis. This case report is the second such case with the these characteristics.

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Most Malignant Fibrous Histiocytomas Developed in the Retroperitoneum Are Dedifferentiated Liposarcomas: A Review of 25 Cases Initially Diagnosed as Malignant Fibrous Histiocytoma

Modern Pathology ◽

10.1097/01.mp.0000056983.78547.77 ◽

2003 ◽

Vol 16 (3) ◽

pp. 256-262 ◽

Cited By ~ 145

Author(s):

Jean-Michel Coindre ◽

Odette Mariani ◽

Frédéric Chibon ◽

Aline Mairal ◽

Nicolas de Saint Aubain Somerhausen ◽

...

Keyword(s):

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Fibrous Histiocytomas ◽

Malignant Fibrous Histiocytomas

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Malignant fibrous histiocytoma of maxilla following radiotherapy for bilateral retinoblastoma

The Journal of Laryngology & Otology ◽

10.1017/s0022215100097127 ◽

1985 ◽

Vol 99 (5) ◽

pp. 501-504 ◽

Cited By ~ 9

Author(s):

S. Nishizawa ◽

T. Hayashida ◽

S. Horiguchi ◽

K. Inouye ◽

T. Imamura

Keyword(s):

Malignant Fibrous Histiocytoma ◽

Autosomal Dominant ◽

Fibrous Histiocytoma ◽

Retinoblastoma Gene ◽

Fibrous Histiocytomas ◽

Malignant Fibrous Histiocytomas ◽

Bilateral Retinoblastoma ◽

Q 14 ◽

The Right ◽

A Site

AbstractA 20-year-old man developed a malignant fibrous histiocytoma in the right maxilla 19 years after irradiation for bilateral retinoblastoma.The incidence of second tumours in patients who survived bilateral retinoblastoma treated with radiation was 8.5 per cent. Malignant fibrous histiocytomas which arise in a site of prior radiation are fatal. The present case is presumed to have the autosomal dominant retinoblastoma gene, not associated with deletion of the q 14 band of chromosome 13. The patient succumbed to the second tumour.

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