Diagnostic difficulties of plunging ranula: case series

2012 ◽  
Vol 126 (5) ◽  
pp. 506-510 ◽  
Author(s):  
R Jain ◽  
R P Morton ◽  
Z Ahmad
Keyword(s):  
New Zealand ◽  
Surgical Management ◽  
Case Series ◽  
Cystic Hygroma ◽  
False Positives ◽  
The Other ◽  
Thyroglossal Cyst ◽  
False Negatives ◽  
Diagnostic Difficulties

AbstractObjectives:To evaluate common pitfalls in diagnosing complicated plunging ranula, either due to misidentification of plunging ranula or alternative pathology (i.e. false negatives or false positives, respectively).Methods:A review of cases of plunging ranula seen in Middlemore Hospital, New Zealand, was performed. Diagnostically uncertain cases were identified and reviewed, taking particular note of clinical, radiological and surgical findings.Results:From our database, 12 cases were found to have had a complicated diagnosis of plunging ranula. Ten cases were false negatives: four were treated as abscesses, four as simple cysts, one as a thyroglossal cyst and one as a cystic hygroma. Two cases were false positives: one was found to be a thyroglossal cyst and the other a lipoma.Conclusion:The diagnosis of plunging ranula is usually straightforward, with simple surgical management. Misdiagnosis can lead to recurrence of symptoms and inappropriate management, with the associated risks, complications and frustrations of surgery.

scholarly journals SurVirus: a repeat-aware virus integration caller

2021 ◽  
Author(s):  
Ramesh Rajaby ◽  
Yi Zhou ◽  
Yifan Meng ◽  
Xi Zeng ◽  
Guoliang Li ◽  
...  
Keyword(s):  
Human Genome ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Second Generation ◽  
False Positives ◽  
The Other ◽  
False Negatives ◽  
Human Cancers ◽  
Human Genomes ◽  
Virus Integration

Abstract A significant portion of human cancers are due to viruses integrating into human genomes. Therefore, accurately predicting virus integrations can help uncover the mechanisms that lead to many devastating diseases. Virus integrations can be called by analysing second generation high-throughput sequencing datasets. Unfortunately, existing methods fail to report a significant portion of integrations, while predicting a large number of false positives. We observe that the inaccuracy is caused by incorrect alignment of reads in repetitive regions. False alignments create false positives, while missing alignments create false negatives. This paper proposes SurVirus, an improved virus integration caller that corrects the alignment of reads which are crucial for the discovery of integrations. We use publicly available datasets to show that existing methods predict hundreds of thousands of false positives; SurVirus, on the other hand, is significantly more precise while it also detects many novel integrations previously missed by other tools, most of which are in repetitive regions. We validate a subset of these novel integrations, and find that the majority are correct. Using SurVirus, we find that HPV and HBV integrations are enriched in LINE and Satellite regions which had been overlooked, as well as discover recurrent HBV and HPV breakpoints in human genome-virus fusion transcripts.

Recovery of Fecal Coliforms and of Escherichia coli at 44.5, 45.0 and 45.5°C

1983 ◽  
Vol 46 (3) ◽  
pp. 172-177 ◽  
Author(s):  
K. F. WEISS ◽  
N. CHOPRA ◽  
P. STOTLAND ◽  
G. W. RIEDEL ◽  
S. MALCOLM
Keyword(s):  
Escherichia Coli ◽  
Incubation Time ◽  
Gas Production ◽  
False Positives ◽  
The Other ◽  
Fecal Coliforms ◽  
False Negatives ◽  
E Coli ◽  
Incubation Temperatures ◽  
Valid Criterion

Recovery rates of fecal coliforms and of Escherichia coli were determined at 44.5, 45.0 and 45.5°C in raw milk, ground meat and raw sewage. MPN values based on gas production (Standard MPNs) and on gas production and/or growth only (Total MPNs) were calculated for both fecal coliforms and for E. coli. The expected trend towards lower MPN values with increasing incubation temperature was more pronounced for the Standard MPNs than for the Total MPNs. The temperature effect was also strongly product - specific in that the Total and Standard MPNs for the fecal coliforms and the Standard MPNs for E. coli for sewage only differed significantly from one another within each determination at the three different incubation temperatures. The effect of length of incubation time on the ratios of E. coli to fecal coliforms was most pronounced at 45.5°C. Product specificity was again observed. The greatest increase in the recovery rate of aerogenic E. coli between 24 and 48 h of incubation time occurred in sewage (66%). For meat, the increase was 57% and for milk 46%. In terms of combined (aerogenic and anaerogenic) E. coli (expressed as Total MPNs), the increases were considerably less, but highest for the meat (33%), followed by sewage (29%) and by milk (21%). A breakdown of the E. coli isolates recovered from both gas-positive and gas-negative primary (fecal coliform) EC broth tubes showed that for the three products combined there were eight times as many false-positives at 44.5°C as at the other two incubation temperatures. In contrast, there were 12% false-negatives at 45.5°C compared to 3% at 45.0°C and 2% at 44.5°C. Since the high incidence of false-negatives (loss of E. coil) at 45.5°C is not counter-balanced by an enhanced specificity (fewer false-positives) over 45.0°C, the latter temperature is to be preferred. Meat yielded the lowest rate for false-positives at any of the three incubation temperatures. In contrast, at 45.5°C, it gave 21% false-negatives compared to only 9% for sewage and 10% for milk. On the other hand, milk contributed the most false-positives at 44.5°C (20%), compared to only 1% for meat and 3% for sewage. A potential loss of 21% of E. coli - containing EC broth tubes is hardly tolerable, reinforcing the contention that gas formation at evaluated temperatures is not a valid criterion of fecal origin.

scholarly journals Clinical outcomes of surgical management for rare types of progressive familial intrahepatic cholestasis: a case series

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Kazunori Masahata ◽  
Takehisa Ueno ◽  
Kazuhiko Bessho ◽  
Tasuku Kodama ◽  
Ryo Tsukada ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Surgical Management ◽  
Intrahepatic Cholestasis ◽  
Case Series ◽  
The Other ◽  
Progressive Familial Intrahepatic Cholestasis ◽  
Donor Liver Transplantation ◽  
Biliary Diversion ◽  
Junction Protein ◽  
Multidrug Resistance Protein 3

Abstract Background Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of genetic autosomal recessive diseases that cause severe cholestasis, which progresses to cirrhosis and liver failure, in infancy or early childhood. We herein report the clinical outcomes of surgical management in patients with four types of PFIC. Case presentation Six patients diagnosed with PFIC who underwent surgical treatment between 1998 and 2020 at our institution were retrospectively assessed. Living-donor liver transplantation (LDLT) was performed in 5 patients with PFIC. The median age at LDLT was 4.8 (range: 1.9–11.4) years. One patient each with familial intrahepatic cholestasis 1 (FIC1) deficiency and bile salt export pump (BSEP) deficiency died after LDLT, and the four remaining patients, one each with deficiency of FIC1, BSEP, multidrug resistance protein 3 (MDR3), and tight junction protein 2 (TJP2), survived. One FIC1 deficiency recipient underwent LDLT secondary to deterioration of liver function, following infectious enteritis. Although he underwent LDLT accompanied by total external biliary diversion, the patient died because of PFIC-related complications. The other patient with FIC1 deficiency had intractable pruritus and underwent partial internal biliary diversion (PIBD) at 9.8 years of age, pruritus largely resolved after PIBD. One BSEP deficiency recipient, who had severe graft damage, experienced recurrence of cholestasis due to the development of antibodies against BSEP after LDLT, and eventually died due to graft failure. The other patient with BSEP deficiency recovered well after LDLT and there was no evidence of posttransplant recurrence of cholestasis. In contrast, recipients with MDR3 or TJP2 deficiency showed good courses and outcomes after LDLT. Conclusions Although LDLT was considered an effective treatment for PFIC, the clinical courses and outcomes after LDLT were still inadequate in patients with FIC1 and BSEP deficiency. LDLT accompanied by total biliary diversion may not be as effective for patients with FIC1 deficiency.

Sky Segmentation for Enhanced Depth Reconstruction and Bokeh Rendering with Efficient Architectures

2020 ◽  
Vol 2020 (14) ◽  
pp. 378-1-378-7
Author(s):  
Tyler Nuanes ◽  
Matt Elsey ◽  
Radek Grzeszczuk ◽  
John Paul Shen
Keyword(s):  
Real Time ◽  
Mobile Device ◽  
Computational Cost ◽  
False Positives ◽  
Compact Model ◽  
High Quality ◽  
False Negatives ◽  
Trade Off ◽  
Depth Reconstruction ◽  
Binary Classifiers

We present a high-quality sky segmentation model for depth refinement and investigate residual architecture performance to inform optimally shrinking the network. We describe a model that runs in near real-time on mobile device, present a new, highquality dataset, and detail a unique weighing to trade off false positives and false negatives in binary classifiers. We show how the optimizations improve bokeh rendering by correcting stereo depth misprediction in sky regions. We detail techniques used to preserve edges, reject false positives, and ensure generalization to the diversity of sky scenes. Finally, we present a compact model and compare performance of four popular residual architectures (ShuffleNet, MobileNetV2, Resnet-101, and Resnet-34-like) at constant computational cost.

Automatic Extraction of Acronyms from Text

2020 ◽  
Author(s):  
Stuart Yeates
Keyword(s):  
Digital Library ◽  
False Positives ◽  
Automatic Extraction ◽  
False Negatives ◽  
Library Research ◽  
Communications Theory ◽  
Textual Content

A brief introduction to acronyms is given and motivation for extracting them in a digital library environment is discussed. A technique for extracting acronyms is given with an analysis of the results. The technique is found to have a low number of false negatives and a high number of false positives. Introduction Digital library research seeks to build tools to enable access of content, while making as few as possible assumptions about the content, since assumptions limit the range of applicability of the tools. Generally, the broader the assumptions the more widely applicable the tools. For example, keyword based indexing [5] is based on communications theory and applies to all natural human textual languages (allowances for differences in character sets and similar localisation issues not withstanding) . The algorithm described in this paper makes much stronger assumptions about the content. It assumes textual content that contains acronyms, an assumption which is known to hold for...

Multicultural and Transnational Novels

2018 ◽  
Author(s):  
James Meffan
Keyword(s):  
National Identity ◽  
New Zealand ◽  
The Other ◽  
Colonial History ◽  
History Of ◽  
Return Home ◽  
Access Rights ◽  
The One

This chapter discusses the history of multicultural and transnational novels in New Zealand. A novel set in New Zealand will have to deal with questions about cultural access rights on the one hand and cultural coverage on the other. The term ‘transnational novel’ gains its relevance from questions about cultural and national identity, questions that have particularly exercised nations formed from colonial history. The chapter considers novels that demonstrate and respond to perceived deficiencies in wider discourses of cultural and national identity by way of comparison between New Zealand and somewhere else. These include Amelia Batistich's Another Mountain, Another Song (1981), Albert Wendt's Sons for the Return Home (1973) and Black Rainbow (1992), James McNeish's Penelope's Island (1990), Stephanie Johnson's The Heart's Wild Surf (2003), and Lloyd Jones's Mister Pip (2006).

scholarly journals Failed Surgery for Patellar Tendinopathy in Athletes: Midterm Results of Further Surgical Management

2021 ◽  
Vol 9 (3) ◽  
pp. 232596712199455
Author(s):  
Nicola Maffulli ◽  
Francesco Oliva ◽  
Gayle D. Maffulli ◽  
Filippo Migliorini
Keyword(s):  
Surgical Management ◽  
Revision Surgery ◽  
Case Series ◽  
Sports Participation ◽  
Patellar Tendinopathy ◽  
Symptom Duration ◽  
Level Of Evidence ◽  
Training Time ◽  
The Mean

Background: Tendon injuries are commonly seen in sports medicine practice. Many elite players involved in high-impact activities develop patellar tendinopathy (PT) symptoms. Of them, a small percentage will develop refractory PT and need to undergo surgery. In some of these patients, surgery does not resolve these symptoms. Purpose: To report the clinical results in a cohort of athletes who underwent further surgery after failure of primary surgery for PT. Study Design: Case series; Level of evidence, 4. Methods: A total of 22 athletes who had undergone revision surgery for failed surgical management of PT were enrolled in the present study. Symptom severity was assessed through the Victorian Institute of Sport Assessment Scale for Patellar Tendinopathy (VISA-P) upon admission and at the final follow-up. Time to return to training, time to return to competition, and complications were also recorded. Results: The mean age of the athletes was 25.4 years, and the mean symptom duration from the index intervention was 15.3 months. At a mean follow-up of 30.0 ± 4.9 months, the VISA-P score improved 27.8 points ( P < .0001). The patients returned to training within a mean of 9.2 months. Fifteen patients (68.2%) returned to competition within a mean of 11.6 months. Of these 15 patients, a further 2 had decreased their performance, and 2 more had abandoned sports participation by the final follow-up. The overall rate of complications was 18.2%. One patient (4.5%) had a further revision procedure. Conclusion: Revision surgery was feasible and effective in patients in whom PT symptoms persisted after previous surgery for PT, achieving a statistically significant and clinically relevant improvement of the VISA-P score as well as an acceptable rate of return to sport at a follow-up of 30 months.

scholarly journals Lack of N2-gene amplification on the Cepheid Xpert Xpress SARS-CoV-2 assay and potential novel causative mutations: A case series from Auckland, New Zealand

IDCases ◽  
2021 ◽  
pp. e01233
Author(s):  
Shivani Fox-Lewis ◽  
Andrew Fox-Lewis ◽  
Jay Harrower ◽  
Richard Chen ◽  
Jing Wang ◽  
...  
Keyword(s):  
New Zealand ◽  
Gene Amplification ◽  
Case Series
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