Adenoid cystic carcinoma of the sinonasal tract: outcome of endonasal endoscopic surgery at five-year follow up

AbstractObjective:To study the outcome of endonasal endoscopic surgery for adenoid cystic carcinoma of the sinonasal tract over a five-year follow-up period.Design:Retrospective analysis.Methods:Four consecutive patients with adenoid cystic carcinoma of the sinonasal tract, who had undergone endonasal endoscopic surgery, were reviewed regarding age at diagnosis, sex, primary site, tumour-node-metastasis staging, treatment modalities, histopathological findings, duration of follow up, distant metastases and treatment outcome.Results:All patients were diagnosed at an advanced stage and had post-operative adjuvant radiotherapy. Three patients underwent endoscopic endonasal resection and one endoscopic assisted craniofacial resection. The most common primary site was the ethmoid sinus (three patients). Three patients had no evidence of recurrence. One patient who had undergone partial clearance via endoscopic endonasal resection developed cervical node metastases a year after treatment; this patient also developed distant metastases.Conclusion:Adenoid cystic carcinoma is difficult to treat. Sinonasal tract tumours can be resected via endoscopic endonasal resection or endoscopic assisted craniofacial resection, but prolonged follow up is advisable. Radiotherapy is an important adjuvant treatment.

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Endoscopic endonasal resection of adenoid cystic carcinoma of the sinonasal tract and skull base

The Laryngoscope ◽

10.1002/lary.27485 ◽

2018 ◽

Vol 129 (5) ◽

pp. 1071-1077 ◽

Cited By ~ 4

Author(s):

Luca Volpi ◽

Maurizio Bignami ◽

Davide Lepera ◽

Apostolos Karligkiotis ◽

Andrea Pistochini ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Skull Base ◽

Sinonasal Tract ◽

Endoscopic Endonasal ◽

Adenoid Cystic

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Distant metastases of adenoid cystic carcinoma of the salivary glands and the value of diagnostic examinations during follow-up

Head & Neck ◽

10.1002/hed.10126 ◽

2002 ◽

Vol 24 (8) ◽

pp. 779-783 ◽

Cited By ~ 141

Author(s):

Jacqueline E. van der Wal ◽

Alfred G. Becking ◽

Gordon B. Snow ◽

Isaac van der Waal

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Distant Metastases ◽

Adenoid Cystic

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Adenoid Cystic Carcinoma of the Upper Trachea: A Rare Neoplasm

Journal of Clinical Imaging Science ◽

10.4103/2156-7514.119021 ◽

2013 ◽

Vol 3 ◽

pp. 39 ◽

Cited By ~ 7

Author(s):

Binoy Kumar Choudhury ◽

Geetanjali Barman ◽

Shobhit Singh ◽

Kuddush Ahmed

Keyword(s):

Adenoid Cystic Carcinoma ◽

Soft Tissue Mass ◽

Distant Metastases ◽

Posterior Wall ◽

Resonance Imaging ◽

Tissue Mass ◽

Adenoid Cystic ◽

History Of ◽

Tracheal Tumors

Primary malignant tracheal tumors are not common and adenoid cystic carcinoma (ACC) of trachea is rare. We report an extremely rare case of ACC of proximal trachea, which was diagnosed in a 42-year-old male who presents with 6-month history of dyspnea. Lateral skiagram of neck, computed tomography, and magnetic resonance imaging revealed a broad-based polypoidal soft tissue mass arising from posterior wall of the proximal trachea. Biopsy confirmed the diagnosis of ACC. The patient was treated by surgical resection followed by radiotherapy and is on regular follow-up. Follow-up at 18 months post-treatment showed no local recurrence or distant metastases. The literature on tracheal ACC is reviewed. Image findings are briefly discussed.

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Adenoid cystic carcinoma of the labium oris with rare metastasis to the pleural cavity

BMJ Case Reports ◽

10.1136/bcr-2020-237622 ◽

2021 ◽

Vol 14 (1) ◽

pp. e237622

Author(s):

Osama Mosalem ◽

Anas Alsara ◽

Fawzi Abu Rous ◽

Borys Hrinczenko

Keyword(s):

Side Effects ◽

Adenoid Cystic Carcinoma ◽

Pleural Cavity ◽

Epigastric Pain ◽

Asian Woman ◽

Upper Lip ◽

Adenoid Cystic ◽

History Of ◽

The Right

A 57-year-old Southeast Asian woman with a remote history of adenoid cystic carcinoma (ACC) of the right labium superius oris (upper lip) presented to the hospital with vague epigastric pain. On workup, she was found to have multiple pleural nodules. Histopathology confirmed the diagnosis of metastatic ACC. After 8 months of active surveillance, evidence of disease progression was found and the patient was started on pembrolizumab. Follow-up after starting pembrolizumab showed stable disease with no significant side effects.

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Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

International Forum of Allergy & Rhinology ◽

10.1002/alr.22255 ◽

2019 ◽

Vol 9 (4) ◽

pp. 427-434 ◽

Cited By ~ 3

Author(s):

Michal Trope ◽

Vasiliki Triantafillou ◽

Michael A. Kohanski ◽

Edward C. Kuan ◽

Charles C.L. Tong ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Sinonasal Tract ◽

National Cancer Database ◽

Adenoid Cystic

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p53, bcl-2 and Ki-67 expression in adenoid cystic carcinoma of the palate. A clinico-pathologic study of 21 cases with long-term follow-up

Pathology - Research and Practice ◽

10.1016/j.prp.2004.08.008 ◽

2005 ◽

Vol 200 (11-12) ◽

pp. 791-799 ◽

Cited By ~ 20

Author(s):

Gabriele Carlinfante ◽

Mirca Lazzaretti ◽

Silvano Ferrari ◽

Bernardo Bianchi ◽

Pellegrino Crafa

Keyword(s):

Adenoid Cystic Carcinoma ◽

Ki 67 ◽

Pathologic Study ◽

Adenoid Cystic ◽

Long Term Follow Up

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Adenoid cystic carcinoma of the salivary glands: Clinicopathological survey of 51 patients

The Journal of Laryngology & Otology ◽

10.1017/s0022215100109703 ◽

1989 ◽

Vol 103 (7) ◽

pp. 675-679 ◽

Cited By ~ 37

Author(s):

V. N. Koka ◽

R. M. Tiwari ◽

I. van der Waal ◽

G. B. Snow ◽

J. Nauta ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Radical Surgery ◽

Neck Region ◽

Distant Metastases ◽

Head And Neck Region ◽

Histological Features ◽

Adenoid Cystic ◽

Small Series ◽

Clinicopathological Study

AbstractA clinicopathological study of 51 cases of adenoid cystic carcinoma in the head and neck region seen over a period of 20 years is presented. The correlation between various histological features and their impact on the results is attempted. Longterm results with respect to loco-regional recurrences, distant metastases and survival with various modalities of therapy are presented. Although this is a small series, radical surgery in keeping with the aim of avoiding undue mutilation, thus preserving the quality of life, followed by a full course of radiotherapy has been the mainstay of treatment and the results here presented justify this approach.

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Adenoid Cystic Carcinoma of the Base of the Tongue

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940111000308 ◽

2001 ◽

Vol 110 (3) ◽

pp. 248-253 ◽

Cited By ~ 19

Author(s):

Ali Namazie ◽

Sassan Alavi ◽

Thomas C. Calcaterra ◽

Elliot Abemayor ◽

Keith E. Blackwell

Keyword(s):

Adenoid Cystic Carcinoma ◽

Postoperative Radiotherapy ◽

Survival Rates ◽

Disease Process ◽

Distant Metastases ◽

Swallowing Function ◽

Term Survival ◽

Adenoid Cystic ◽

Regional Metastases ◽

Carcinoma Of The Tongue

A retrospective review of 14 patients with adenoid cystic carcinoma of the tongue treated between 1955 and 1997 was performed. Treatment consisted of surgery (n = 2), radiotherapy (n = 2), chemotherapy (n = 1), or combination therapy (n = 9). The 2-, 5-, and 10-year absolute survival rates were 92%, 79%, and 63%, respectively. Seventy-five percent of the patients who died of cancer succumbed to distant metastases. However, long-term survival was common despite a high incidence of local and distant recurrence. The presence of positive surgical margins, the incidence of regional metastases, the incidence of perineural invasion, the initial stage of disease, and the eventual development of locoregional recurrence and distant metastases did not significantly alter the survival rate. Surgical extirpation combined with postoperative radiotherapy is advocated for the treatment of adenoid cystic carcinoma of the tongue. Given the indolent nature of this disease process, surgery should be directed toward conservation of speech and swallowing function.

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