p53, bcl-2 and Ki-67 expression in adenoid cystic carcinoma of the palate. A clinico-pathologic study of 21 cases with long-term follow-up

2005 ◽  
Vol 200 (11-12) ◽  
pp. 791-799 ◽  
Author(s):  
Gabriele Carlinfante ◽  
Mirca Lazzaretti ◽  
Silvano Ferrari ◽  
Bernardo Bianchi ◽  
Pellegrino Crafa
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Ki 67 ◽  
Pathologic Study ◽  
Adenoid Cystic ◽  
Long Term Follow Up

Adenoid cystic carcinoma of trachea: long-term disease control after endoscopic surgery and radiotherapy

2019 ◽  
Author(s):  
Corrado Spatola ◽  
Alessandra Tocco ◽  
Dario Marletta ◽  
Roberto Milazzotto ◽  
Francesco Marletta ◽  
...  
Keyword(s):  
Disease Control ◽  
Adenoid Cystic Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Neck Region ◽  
Intensity Modulated ◽  
Adenoid Cystic ◽  
The Impact

Aim: Adenoid cystic carcinoma is a rare tumor of head and neck region and its development in the thoracic region is even less frequent. This implies the absence of guidelines for therapeutic management and a consequent case-by-case approach. The role of radiotherapy is not yet clearly defined, but intensity-modulated radiotherapy allows for improved organ-at-risk sparing. Materials & methods: We have collected the cases of four patients treated at our institutions by the means of intensity-modulated radiotherapy, after endoscopic resection. Results & conclusion: Patients treated achieved long-term disease control of about 5 years, with a minimal acute toxicity. Longer follow-up is needed to drain conclusion on the impact of this treatment on overall survival.

scholarly journals Tubal metaplasia of the endometrium with cytologic atypia: analysis of p53, Ki-67, TERT, and long-term follow-up

2011 ◽  
Vol 24 (9) ◽  
pp. 1254-1261 ◽  
Author(s):  
Rochelle A Simon ◽  
Shu-Ling Peng ◽  
Fang Liu ◽  
M Ruhul Quddus ◽  
Cunxian Zhang ◽  
...  
Keyword(s):  
Ki 67 ◽  
Cytologic Atypia ◽  
Long Term Follow Up

Oligodendroglioma arising in the glial component of ovarian teratomas: a series of six cases and review of literature

2012 ◽  
Vol 65 (7) ◽  
pp. 631-634 ◽  
Author(s):  
Nasir Ud Din ◽  
Aisha Memon ◽  
Kanwal Aftab ◽  
Zubair Ahmad ◽  
Rashida Ahmed ◽  
...  
Keyword(s):  
Review Of Literature ◽  
Ki 67 ◽  
Who Grade ◽  
Long Term Follow Up ◽  
Grade Ii ◽  
The Right ◽  
Rule Out ◽  
Ovarian Teratomas

AimsTo report the exceedingly rare occurrence of oligodendroglioma in the glial component of ovarian teratomas.MethodsSix cases of oligodendrogliomas arising in the glial component of ovarian teratomas were studied and the literature was reviewed. Immunohistochemistry was performed by the Flex technique.ResultsThe ages of the patients ranged from 12 to 28 years (mean 21 years). Four tumours were located in the right and one in the left ovary. The size of the ovarian cysts ranged from 7 cm to 29 cm (mean 19.6 cm). Four cases arose in immature and two cases in mature teratomas. In all cases, oligodendroglioma was WHO grade II. On immunohistochemistry, glial fibrillary acidic protein stain was positive in all cases. The Mib 1 (Ki 67) proliferative index was low and the tumour cells were negative for synaptophysin. Follow-up was available in five patients and ranged from 1 to 42 months. Two patients died of disease after 1 and 36 months of diagnosis, respectively. In both these cases oligodendroglioma arose in an immature teratoma. The remaining three patients are alive with a follow-up of 4–42 months.ConclusionsOligodendroglioma arising in the glial component of ovarian teratomas is exceedingly rare. Ovarian teratomas should be extensively sampled and carefully evaluated to rule out the possibility of a glial tumour. This is the single and largest series of oligodendrogliomas arising in ovarian teratomas. The prognosis is good for oligodendrogliomas arising in mature teratomas compared with those arising in immature teratomas, although long-term follow-up is needed to determine the exact behaviour.

Metastatic Patterns of Salivary Gland Neoplasms

1982 ◽  
Vol 91 (4) ◽  
pp. 465-466 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Salivary Gland ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Regional Lymph Nodes ◽  
Adenoid Cystic ◽  
Salivary Gland Carcinomas ◽  
Long Term Follow Up ◽  
Metastatic Patterns

Long-term follow-up of salivary gland carcinomas allows a better evaluation of their biologic malignancy than the traditional five-year period. Metastases (distant and local) are possible over the entire lifetime of a patient and are dependent upon histologic grade, persistence of neoplasm and clinical stage. Distant metastases to bone and lungs are manifested by nearly every carcinoma. Metastases to regional lymph nodes vary according to histologic type and it appears that the adenoid cystic carcinoma has the lowest incidence of that event.

scholarly journals Clinical challenges of a co-secreting TSH/GH pituitary adenoma

2019 ◽  
Vol 2019 ◽  
Author(s):  
Hui Yi Ng ◽  
Divya Namboodiri ◽  
Diana Learoyd ◽  
Andrew Davidson ◽  
Bernard Champion ◽  
...  
Keyword(s):  
List Type ◽  
Cell Of Origin ◽  
Glycoprotein Hormone ◽  
Ki 67 ◽  
Long Term Follow Up ◽  
Surgical Cure ◽  
Term Data ◽  
Gh Excess

Summary Co-secreting thyrotropin/growth hormone (GH) pituitary adenomas are rare; their clinical presentation and long-term management are challenging. There is also a paucity of long-term data. Due to the cell of origin, these can behave as aggressive tumours. We report a case of a pituitary plurihormonal pit-1-derived macroadenoma, with overt clinical hyperthyroidism and minimal GH excess symptoms. The diagnosis was confirmed by pathology showing elevated thyroid and GH axes with failure of physiological GH suppression, elevated pituitary glycoprotein hormone alpha subunit (αGSU) and macroadenoma on imaging. Pre-operatively the patient was rendered euthyroid with carbimazole and underwent successful transphenoidal adenomectomy (TSA) with surgical cure. Histopathology displayed an elevated Ki-67 of 5.2%, necessitating long-term follow-up. Learning points: Thyrotropinomas are rare and likely under-diagnosed due to under-recognition of secondary hyperthyroidism. Thyrotropinomas and other plurihormonal pit-1-derived adenomas are more aggressive adenomas according to WHO guidelines. Co-secretion occurs in 30% of thyrotropinomas, requiring diligent investigation and long-term follow-up of complications.

Proliferation Index of Nonfunctioning Pituitary Adenomas: Correlations with Clinical Characteristics and Long-term Follow-up Results

Neurosurgery ◽  
2000 ◽  
Vol 47 (6) ◽  
pp. 1313-1319 ◽  
Author(s):  
Marco Losa ◽  
Alberto Franzin ◽  
Francesca Mangili ◽  
Maria Rosa Terreni ◽  
Raffaella Barzaghi ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Tumor Recurrence ◽  
Clinical Characteristics ◽  
Ki 67 ◽  
Nonfunctioning Pituitary Adenomas ◽  
Age At Surgery ◽  
Long Term Follow Up ◽  
The Mean

ABSTRACT OBJECTIVE The recurrence of nonfunctioning pituitary adenomas (NFPAs) after surgical removal is common. The aim of our study was to investigate and correlate the growth fraction of NFPAs with clinical characteristics and long-term follow-up results. METHODS Tumor specimens were obtained from 101 consecutive patients with NFPAs (48 female patients and 53 male patients; mean age, 52.0 ± 1.5 yr). Specimens were immediately fixed in 10% buffered formalin and then embedded in paraffin. The Ki-67 antigen was assessed by immunocytochemical analysis using the monoclonal antibody MIB-1. The Ki-67 antigen labeling index (LI) was determined by counting a total of at least 1000 neoplastic nuclei. RESULTS The mean Ki-67 LI for the 101 patients was 2.4 ± 0.3% (range, 0–23.0%). Only age at surgery was inversely correlated with the Ki-67 LI; sex, maximal tumor diameter, and invasiveness into the cavernous sinuses did not significantly affect the Ki-67 LI. The mean follow-up period was 39.7 ± 2.1 months. During follow-up monitoring, 23 patients experienced tumor recurrence, after a mean period of 28.6 ± 4.8 months. Invasiveness of the tumor on preoperative magnetic resonance imaging scans was the strongest predictor of late tumor recurrence, followed by previous pituitary surgery, younger age, and lack of postoperative radiotherapy. The Ki-67 LI had no independent prognostic value. CONCLUSION Our study suggests that the clinical characteristics of patients with NFPAs, except for age at surgery, are not correlated with the Ki-67 LI. Moreover, the Ki-67 LI does not seem to provide independent information to identify patients at high risk for tumor recurrence.

scholarly journals The Proper Ki-67 Cut-Off in Hormone Responsive Breast Cancer: A Monoinstitutional Analysis with Long-Term Follow-Up

2021 ◽  
Vol Volume 13 ◽  
pp. 213-217
Author(s):  
Augusto Lombardi ◽  
Rachele Lazzeroni ◽  
Laura Bersigotti ◽  
Valeria Vitale ◽  
Claudio Amanti
Keyword(s):  
Breast Cancer ◽  
Ki 67 ◽  
Long Term Follow Up

scholarly journals Prognostic Factors for Long-Term Survival after Surgical Resection of Primary Cardiac Sarcoma

2019 ◽  
Vol 67 (08) ◽  
pp. 665-671 ◽  
Author(s):  
Anas Aboud ◽  
Kassar Farha ◽  
Wan Chin Hsieh ◽  
Frank Brasch ◽  
Stephan Ensminger ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Ki 67 ◽  
Term Survival ◽  
Long Term Survival ◽  
Long Term Follow Up ◽  
Synovial Sarcomas ◽  
Histological Characteristics ◽  
Primary Cardiac Sarcoma

Background Primary cardiac sarcoma (CS) is an extremely rare disease. This study aims to identify possible prognostic factors for long-term survival. Methods A total of 17 consecutive patients who were treated for primary CS between 2003 und 2018 at two cardiac centers were investigated. Clinical data and histological characteristics of the tumors were analyzed. Long-term follow-up of all patients were performed. Results The median age was 54 years (range: 23–74). The tumors originated from the left side of the heart in nine patients. Histologically, there were four angiosarcomas, three intimal sarcomas, and three synovial sarcomas. One- and 7-year survivals were 81.9 and 18.2%, respectively. Low expression levels of Ki-67 tended to be associated with increased survival (log-rank p = 0.06). Adjuvant chemotherapy but not radiotherapy regardless of existing metastases was associated with significantly increased survival (log-rank p = 0.001). Conclusion Angiosarcoma was the most common type of CS. The survival of CS patients is poor but prognostic factors, such as Ki-67, may help estimate the course of the disease. Survival could be improved significantly with chemotherapy.

Sign in / Sign up

Export Citation Format

Share Document