The current status of antiparasite chemotherapy

Parasitology ◽  
1997 ◽  
Vol 114 (7) ◽  
pp. 3-15 ◽  
Author(s):  
S. L. CROFT
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Sesquiterpene Lactones ◽  
Molecular Targets ◽  
Structure And Function ◽  
Current Status ◽  
Rational Approach ◽  
Pharmacological Properties ◽  
Antiparasitic Drugs ◽  
And Function

Currently used antiparasitic drugs, including benzimidazoles, nitroimidazoles, avermectins, polyene ionophores, hydroxynaphthoquinones and sesquiterpene lactones, were identified through the empirical route to drug discovery. The modern rational approach to drug design is focused upon the structure and function of biochemical and molecular targets. The requisite pharmacological properties for new anti-parasite drugs should not be ignored in this process.

Probing the Structure and Function of Human Glutaminase-Interacting Protein: A Possible Target for Drug Design†‡

Biochemistry ◽  
2008 ◽  
Vol 47 (35) ◽  
pp. 9208-9219 ◽  
Author(s):  
Monimoy Banerjee ◽  
Chengdong Huang ◽  
Javier Marquez ◽  
Smita Mohanty
Keyword(s):  
Drug Design ◽  
Protein A ◽  
Structure And Function ◽  
Interacting Protein ◽  
And Function

scholarly journals Structure and function of Zika virus NS5 protein: perspectives for drug design

2018 ◽  
Vol 75 (10) ◽  
pp. 1723-1736 ◽  
Author(s):  
Boxiao Wang ◽  
Stephanie Thurmond ◽  
Rong Hai ◽  
Jikui Song
Keyword(s):  
Drug Design ◽  
Zika Virus ◽  
Structure And Function ◽  
And Function

scholarly journals Structure prediction of crystals, surfaces and nanoparticles

2020 ◽  
Vol 378 (2186) ◽  
pp. 20190600
Author(s):  
Scott M. Woodley ◽  
Graeme M. Day ◽  
R. Catlow
Keyword(s):  
Machine Learning ◽  
Energy Function ◽  
Structure Prediction ◽  
Search Algorithm ◽  
Structure And Function ◽  
Current Status ◽  
Organic Systems ◽  
And Function

We review the current techniques used in the prediction of crystal structures and their surfaces and of the structures of nanoparticles. The main classes of search algorithm and energy function are summarized, and we discuss the growing role of methods based on machine learning. We illustrate the current status of the field with examples taken from metallic, inorganic and organic systems. This article is part of a discussion meeting issue ‘Dynamic in situ microscopy relating structure and function’.

The structure and function of the brown fat uncoupling protein UCP1: current status

BioFactors ◽  
1998 ◽  
Vol 8 (3-4) ◽  
pp. 209-219 ◽  
Author(s):  
Eduardo Rial ◽  
M. Mar González-Barroso ◽  
Christophe Fleury ◽  
Frédéric Bouillaud
Keyword(s):  
Uncoupling Protein ◽  
Structure And Function ◽  
Brown Fat ◽  
Current Status ◽  
And Function

scholarly journals G-Protein coupled receptors: structure and function in drug discovery

RSC Advances ◽  
2020 ◽  
Vol 10 (60) ◽  
pp. 36337-36348 ◽  
Author(s):  
Chiemela S. Odoemelam ◽  
Benita Percival ◽  
Helen Wallis ◽  
Ming-Wei Chang ◽  
Zeeshan Ahmad ◽  
...  
Keyword(s):  
Drug Discovery ◽  
G Protein ◽  
Mammalian Genome ◽  
Structure And Function ◽  
G Protein Coupled Receptors ◽  
And Function ◽  
G Protein Coupled

The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome.

Sign in / Sign up

Export Citation Format

Share Document