Endocrine and behavioural responses to methylphenidate in depression
Keyword(s):
SynopsisTwenty patients with a major depressive disorder and 20 control subjects were subjected to a 1 mg dexamethasone suppression test (DST) and a challenge with intravenous (IV) methylphenidate (MP)(0·3 mg/kg). None of the controls, but 9 depressives, were DST non-suppressors. Among the depressives there were correlations between DST-cortisol and baseline (4 p.m.) levels of cortisol, growth hormone, prolactin and adrenaline. Compared with the controls the depressives had a decreased cortisol response and an enhanced adrenaline response to the MP challenge. The decreased cortisol response was not related to either DST-cortisol or baseline cortisol, but was correlated with the mood response to MP.
1988 ◽
Vol 77
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pp. 404-410
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1983 ◽
Vol 142
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pp. 498-504
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1992 ◽
Vol 149
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pp. 1040-1045
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1985 ◽
Vol 8
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pp. 191-195
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1999 ◽
Vol 33
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pp. 274-277
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1984 ◽
Vol 145
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pp. 383-388
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1992 ◽
Vol 31
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pp. 291-297
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1985 ◽
Vol 10
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pp. 173-186
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