The dexamethasone suppression test in adolescent outpatients with major depressive disorder

1992 ◽  
Vol 149 (8) ◽  
pp. 1040-1045 ◽  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Suppression Test ◽  
Dexamethasone Suppression

Dexamethasone Suppression Test in Depression and other Psychiatric Illness

1983 ◽  
Vol 142 (5) ◽  
pp. 498-504 ◽  
Author(s):  
A. Coppen ◽  
M. Abou-Saleh ◽  
P. Milln ◽  
M. Metcalfe ◽  
J. Harwood ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Affective Disorders ◽  
Psychiatric Illness ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Abnormal Response ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Normal Controls

SummaryThe prevalence of an abnormal response to the dexamethasone suppression test (DST) was examined in 119 in-patients suffering from a major depressive disorder and in 79 normal controls. Only 11 per cent of controls showed an abnormal DST as against 70 per cent of depressed patients. The specificity of the DST was examined by testing patients with other psychiatric disorders. Abnormal responses were found in one-fifth of a sample of schizophrenics, over one-quarter of abstinent alcoholics, two-fifths of neurotics (including neurotic depressives) and almost half of senile dements. Abnormal DST was also found in 33 per cent of patients receiving prophylactic lithium for recurrent affective disorders.

Endocrine and behavioural responses to methylphenidate in depression

1986 ◽  
Vol 16 (3) ◽  
pp. 531-540 ◽  
Author(s):  
Peter R. Joyce ◽  
Richard A. Donald ◽  
M. Gary Nicholls ◽  
John H. Livesey ◽  
Robyn M. Abbott
Keyword(s):  
Growth Hormone ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dexamethasone Suppression Test ◽  
Cortisol Response ◽  
Major Depressive ◽  
Behavioural Responses ◽  
Baseline Cortisol ◽  
Suppression Test ◽  
Dexamethasone Suppression

SynopsisTwenty patients with a major depressive disorder and 20 control subjects were subjected to a 1 mg dexamethasone suppression test (DST) and a challenge with intravenous (IV) methylphenidate (MP)(0·3 mg/kg). None of the controls, but 9 depressives, were DST non-suppressors. Among the depressives there were correlations between DST-cortisol and baseline (4 p.m.) levels of cortisol, growth hormone, prolactin and adrenaline. Compared with the controls the depressives had a decreased cortisol response and an enhanced adrenaline response to the MP challenge. The decreased cortisol response was not related to either DST-cortisol or baseline cortisol, but was correlated with the mood response to MP.

Dexamethasone Suppression Test Reversal in Rapid Transcranial Magnetic Stimulation-Treated Depression

1999 ◽  
Vol 33 (2) ◽  
pp. 274-277 ◽  
Author(s):  
Philip D. Reid ◽  
Saxby Pridmore
Keyword(s):  
Major Depressive Disorder ◽  
Transcranial Magnetic Stimulation ◽  
Depressive Disorder ◽  
Magnetic Stimulation ◽  
Rating Scales ◽  
Past History ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Suppression Test ◽  
Dexamethasone Suppression

Objective: The aim of this paper is to report the effect of rapid transcranial magnetic stimulation (rTMS) on the mood and dexamethasone suppression test (DST) of a patient with major depressive disorder (DSM-IV). Clinical picture: A36-year-old woman with a past history of prolactinoma and recurrent major depressive disorder presented with major depression on three separate occasions over a 3-month period. DST was positive on each occasion. Treatment: During each episode, a course of rTMS was given. Courses varied from seven to 13 once-daily treatment sessions depending on clinical response. These treatment sessions were 20 trains of 10 Hz for 5 s at 100% of motor threshold. Outcome: Remission was achieved, psychiatric rating scales improved and the DST status converted from positive to negative. There were no side effects. Conclusion: DST status in major depressive disorder can be converted from positive to negative by rTMS. This so far unreported observation increases our knowledge of rTMS.

Dexamethasone Suppression Test and REM Sleep in Patients with Major Depressive Disorder

1984 ◽  
Vol 145 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Julien Mendlewicz ◽  
Myriam Kerkhofs ◽  
Guy Hoffmann ◽  
Paul Linkowski
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Depressed Patients ◽  
Significant Difference ◽  
Rem Latency ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Normal Controls

SummaryDexamethasone suppression Test (DST) and sleep electroencephalogram (EEG) recordings were carried out during three consecutive nights in 39 depressed patients who met Research Diagnostic Criteria (RDC) for major depressive disorder and in nine normal controls. Cortisol response to DST was abnormal in 26 patients and normal in all controls. REM latency and REM density were compared in patients with abnormal DST (n = 26) to values obtained in patients with normal DST (n = 13) and in normal controls (n = 9). Rapid Eye Movement (REM) latencies were significantly lower in depressed patients showing cortisol non-suppression after dexamethasone than in patients with a normal DST or in controls. REM densities were significantly higher in depressed patients than in normal controls (P <0.025), but there was no significant difference between DST suppressors and non–suppressors. The DST provided high specificity (100%) and a sensitivity of 67%, while REM latency showed a lower specificity (78%), but a higher sensitivity (85%).

Dexamethasone Suppression Test in Children with Major Depressive Disorder

1992 ◽  
Vol 31 (2) ◽  
pp. 291-297 ◽  
Author(s):  
BORIS BIRMAHER ◽  
NEAL D. RYAN ◽  
RONALD DAHL ◽  
HARRIS RABINOVICH ◽  
PAUL AMBROSINI ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Suppression Test ◽  
Dexamethasone Suppression
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