Transdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys report

Abstract Background Depressive and anxiety disorders are highly comorbid, which has been theorized to be due to an underlying internalizing vulnerability. We aimed to identify groups of participants with differing vulnerabilities by examining the course of internalizing psychopathology up to age 45. Methods We used data from 24158 participants (aged 45+) in 23 population-based cross-sectional World Mental Health Surveys. Internalizing disorders were assessed with the Composite International Diagnostic Interview (CIDI). We applied latent class growth analysis (LCGA) and investigated the characteristics of identified classes using logistic or linear regression. Results The best-fitting LCGA solution identified eight classes: a healthy class (81.9%), three childhood-onset classes with mild (3.7%), moderate (2.0%), or severe (1.1%) internalizing comorbidity, two puberty-onset classes with mild (4.0%) or moderate (1.4%) comorbidity, and two adult-onset classes with mild comorbidity (2.7% and 3.2%). The childhood-onset severe class had particularly unfavorable sociodemographic outcomes compared to the healthy class, with increased risks of being never or previously married (OR = 2.2 and 2.0, p < 0.001), not being employed (OR = 3.5, p < 0.001), and having a low/low-average income (OR = 2.2, p < 0.001). Moderate or severe (v. mild) comorbidity was associated with 12-month internalizing disorders (OR = 1.9 and 4.8, p < 0.001), disability (B = 1.1–2.3, p < 0.001), and suicidal ideation (OR = 4.2, p < 0.001 for severe comorbidity only). Adult (v. childhood) onset was associated with lower rates of 12-month internalizing disorders (OR = 0.2, p < 0.001). Conclusions We identified eight transdiagnostic trajectories of internalizing psychopathology. Unfavorable outcomes were concentrated in the 1% of participants with childhood onset and severe comorbidity. Early identification of this group may offer opportunities for preventive interventions.

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Intermittent explosive disorder subtypes in the general population: association with comorbidity, impairment and suicidality

Epidemiology and Psychiatric Sciences ◽

10.1017/s2045796020000517 ◽

2020 ◽

Vol 29 ◽

Author(s):

K. M. Scott ◽

Y. A. de Vries ◽

S. Aguilar-Gaxiola ◽

A. Al-Hamzawi ◽

J. Alonso ◽

...

Keyword(s):

Mental Health ◽

General Population ◽

Functional Impairment ◽

Clinical Studies ◽

Health Surveys ◽

Composite International Diagnostic Interview ◽

Comorbid Disorders ◽

Intermittent Explosive Disorder ◽

World Mental Health ◽

Anger Attacks

Abstract Aims Intermittent explosive disorder (IED) is characterised by impulsive anger attacks that vary greatly across individuals in severity and consequence. Understanding IED subtypes has been limited by lack of large, general population datasets including assessment of IED. Using the 17-country World Mental Health surveys dataset, this study examined whether behavioural subtypes of IED are associated with differing patterns of comorbidity, suicidality and functional impairment. Methods IED was assessed using the Composite International Diagnostic Interview in the World Mental Health surveys (n = 45 266). Five behavioural subtypes were created based on type of anger attack. Logistic regression assessed association of these subtypes with lifetime comorbidity, lifetime suicidality and 12-month functional impairment. Results The lifetime prevalence of IED in all countries was 0.8% (s.e.: 0.0). The two subtypes involving anger attacks that harmed people (‘hurt people only’ and ‘destroy property and hurt people’), collectively comprising 73% of those with IED, were characterised by high rates of externalising comorbid disorders. The remaining three subtypes involving anger attacks that destroyed property only, destroyed property and threatened people, and threatened people only, were characterised by higher rates of internalising than externalising comorbid disorders. Suicidal behaviour did not vary across the five behavioural subtypes but was higher among those with (v. those without) comorbid disorders, and among those who perpetrated more violent assaults. Conclusions The most common IED behavioural subtypes in these general population samples are associated with high rates of externalising disorders. This contrasts with the findings from clinical studies of IED, which observe a preponderance of internalising disorder comorbidity. This disparity in findings across population and clinical studies, together with the marked heterogeneity that characterises the diagnostic entity of IED, suggests that it is a disorder that requires much greater research.

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Parent psychopathology and offspring mental disorders: Results from the WHO World Mental Health Surveys

The British Journal of Psychiatry ◽

10.1192/bjp.bp.111.101253 ◽

2012 ◽

Vol 200 (4) ◽

pp. 290-299 ◽

Cited By ~ 105

Author(s):

Katie A. McLaughlin ◽

Anne M. Gadermann ◽

Irving Hwang ◽

Nancy A. Sampson ◽

Ali Al-Hamzawi ◽

...

Keyword(s):

Mental Health ◽

Mental Disorders ◽

Health Surveys ◽

Population Attributable Risk ◽

Antisocial Behaviour ◽

Composite International Diagnostic Interview ◽

Diagnostic Interview ◽

World Health ◽

Parent Psychopathology ◽

World Mental Health

BackgroundAssociations between specific parent and offspring mental disorders are likely to have been overestimated in studies that have failed to control for parent comorbidity.AimsTo examine the associations of parent with respondent disorders.MethodData come from the World Health Organization (WHO) World Mental Health Surveys (n = 51 507). Respondent disorders were assessed with the Composite International Diagnostic Interview and parent disorders with informant-based Family History Research Diagnostic Criteria interviews.ResultsAlthough virtually all parent disorders examined (major depressive, generalised anxiety, panic, substance and antisocial behaviour disorders and suicidality) were significantly associated with offspring disorders in multivariate analyses, little specificity was found. Comorbid parent disorders had significant sub-additive associations with offspring disorders. Population-attributable risk proportions for parent disorders were 12.4% across all offspring disorders, generally higher in high- and upper-middle- than low-/lower-middle-income countries, and consistently higher for behaviour (11.0–19.9%) than other (7.1–14.0%) disorders.ConclusionsParent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders.

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Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys

BMC Medicine ◽

10.1186/s12916-019-1328-3 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

Ymkje Anna de Vries ◽

◽

Ali Al-Hamzawi ◽

Jordi Alonso ◽

Guilherme Borges ◽

...

Keyword(s):

Mental Health ◽

Health Surveys ◽

Specific Phobia ◽

Early Marker ◽

Internalizing Psychopathology ◽

World Mental Health ◽

The World

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Concordance of the Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health Surveys

International Journal of Methods in Psychiatric Research ◽

10.1002/mpr.196 ◽

2006 ◽

Vol 15 (4) ◽

pp. 167-180 ◽

Cited By ~ 663

Author(s):

Josep Maria Haro ◽

Saena Arbabzadeh-Bouchez ◽

Traolach S. Brugha ◽

Giovanni De Girolamo ◽

Margaret E. Guyer ◽

...

Keyword(s):

Mental Health ◽

Health Surveys ◽

Composite International Diagnostic Interview ◽

Diagnostic Interview ◽

Clinical Assessments ◽

World Mental Health

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Supplemental Material for WHO World Mental Health Surveys International College Student Project: Prevalence and Distribution of Mental Disorders

Journal of Abnormal Psychology ◽

10.1037/abn0000362.supp ◽

2018 ◽

Cited By ~ 2

Keyword(s):

Mental Health ◽

College Student ◽

Mental Disorders ◽

Health Surveys ◽

World Mental Health ◽

International College

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Concordance between the diagnostic guidelines for alcohol and cannabis use disorders in the draft ICD‐11 and other classification systems: analysis of data from the WHO's World Mental Health Surveys

Addiction ◽

10.1111/add.14482 ◽

2018 ◽

Cited By ~ 4

Author(s):

Louisa Degenhardt ◽

Chrianna Bharat ◽

Raimondo Bruno ◽

Meyer D. Glantz ◽

Nancy A. Sampson ◽

...

Keyword(s):

Mental Health ◽

Systems Analysis ◽

Health Surveys ◽

Classification Systems ◽

Cannabis Use ◽

World Mental Health ◽

Cannabis Use Disorders

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Family functioning but not social capital is associated with better mental health in adolescents affected by violence and displacement by armed conflict in Colombia

International Journal of Social Psychiatry ◽

10.1177/00207640211045417 ◽

2021 ◽

pp. 002076402110454

Author(s):

William Tamayo-Aguledo ◽

Alida Acosta-Ortiz ◽

Aseel Hamid ◽

Carolina Gómez-García ◽

María Camila García-Durán ◽

...

Keyword(s):

Mental Health ◽

Social Capital ◽

Family Functioning ◽

Armed Conflict ◽

Composite International Diagnostic Interview ◽

Poor Mental Health ◽

Diagnostic Interview ◽

Cross Sectional ◽

Nationally Representative ◽

Cognitive Social Capital

Background: The effect of the Colombian armed conflict on the mental health of adolescents is still poorly understood. Aims: Given social interventions are most likely to inform policy, we tested whether two potential intervention targets, family functioning and social capital, were associated with mental health in Colombian adolescents, and whether this was moderated by experience of violence and displacement. Methods: We examined the cross-sectional association between family functioning, cognitive social capital, structural social capital and 12-month prevalence of Composite International Diagnostic Interview (CIDI) diagnosed psychiatric disorder, using data on 12 to 17-year-old adolescents ( N = 1,754) from the 2015 National Mental Health Survey of Colombia, a nationally representative epidemiological study. We tested whether associations survived cumulative adjustment for demographic confounders, experience of non-specific violence and harm and displacement by armed conflict. Results: Neither structural nor cognitive social capital were associated with better mental health. Better family functioning was associated with reduced risk of poor mental health in an unadjusted analysis (OR 0.90 [0.85–0.96]), and after cumulative adjustments for demographic confounders (OR 0.91 [0.86–0.97]), non-specific violence and harm (OR 0.91 [0.86–0.97]) and social capital variables (OR 0.91 [0.85–0.97]). In the final model, each additional point on the family APGAR scale was associated with a 9% reduced odds of any CIDI diagnosed disorder in the last 12 months. Conclusions: Better family functioning was associated with better mental health outcomes for all adolescents. This effect remained present in those affected by the armed conflict even after accounting for potential confounders.

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Latent Class Analysis of DSM-5 Criteria for Opioid Use Disorders: Results from the Iranian National Survey on Mental Health

European Addiction Research ◽

10.1159/000369338 ◽

2015 ◽

Vol 21 (3) ◽

pp. 144-152 ◽

Cited By ~ 7

Author(s):

Mohammad Javad Tarrahi ◽

Afarin Rahimi-Movaghar ◽

Hojjat Zeraati ◽

Seyed Abbas Motevalian ◽

Masoumeh Amin-Esmaeili ◽

...

Keyword(s):

Mental Health ◽

Latent Class ◽

Composite International Diagnostic Interview ◽

Opioid Use Disorder ◽

Diagnostic Interview ◽

Opioid Use ◽

Dsm 5 ◽

Legal Problems ◽

Dsm Iv ◽

Opioid Users

Background: Assessments of DSM-IV and DSM-5 criteria with sample populations of opioid users are limited. This study aimed to determine the number of latent classes in opioid users and assessment of the proposed revisions to the DSM-5 opioid use disorder (OUD) criteria. Methods: Data came from the 2011 Iranian National Mental Health Survey (IranMHS) on 7,886 participants aged 15-64 years living in Iran. We used the Composite International Diagnostic Interview (CIDI) version 2.1 in all respondents who indicated using opioids at least 5 times in the previous 12 months (n = 236). Results: A three-class model provided the best fit of all the models tested. Classes showed a spectrum of severity that was compatible with the DSM-5 classification. ‘Legal problems' and ‘desire to cut down' showed poor discrimination between classes. The weighted prevalence of OUD using DSM-5 was 20.7% higher than with DSM-IV. Conclusions: Results support the grouping based on severity of symptoms, combining abuse and dependence into a single diagnosis, omitting legal problems, and addition of craving as a new criterion.

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