Do the biological details matter?

1997 ◽  
Vol 20 (4) ◽  
pp. 684-685 ◽  
Author(s):  
James M. Bower
Keyword(s):  
Neuronal Activity ◽  
Visual Stimuli ◽  
Theoretical Work ◽  
Cortical Processing ◽  
Proof Of Concept ◽  
Processing Scheme ◽  
Concept Model ◽  
Cortical Oscillations ◽  
Target Article ◽  
Cell Firing

Phillips & Singer (P&S) extend ideas derived from the observation eight years ago that the coherence (synchronization) of cortical oscillations can be modulated by the structure of visual stimuli. As described in the target article, a large part of the continued interest in this finding is related to independent theoretical work suggesting that synchronized cell firing could help solve the problem of binding together within cortex neuronal activity associated with different attributes of visual stimuli. The authors present an abstract “proof of concept” model describing how their cortical processing scheme could work, but our biologically realistic models of cortical relationships suggest that the proposal is biologically implausible. Our realistic models lead to a very different interpretation of the significance of cortical oscillations.

scholarly journals Influence of Janus kinase inhibitors on the neuronal activity as proof-of-concept model for itch

2021 ◽  
Author(s):  
Johannes Wohlrab ◽  
David Stintzing ◽  
Luise Schultz ◽  
Konstantin Jügelt ◽  
Olaf H.-U. Schroeder
Keyword(s):  
Neuronal Activity ◽  
Kinase Inhibitors ◽  
Janus Kinase ◽  
Proof Of Concept ◽  
Janus Kinase Inhibitors ◽  
Concept Model

scholarly journals Verification and Strategy Synthesis for Coalition Announcement Logic

2021 ◽  
Author(s):  
Natasha Alechina ◽  
Hans van Ditmarsch ◽  
Rustam Galimullin ◽  
Tuo Wang
Keyword(s):  
Model Checking ◽  
Proof Of Concept ◽  
Model Checker ◽  
Complete Model ◽  
Concept Model ◽  
The Family ◽  
Winning Strategies ◽  
Epistemic Goals

AbstractCoalition announcement logic (CAL) is one of the family of the logics of quantified announcements. It allows us to reason about what a coalition of agents can achieve by making announcements in the setting where the anti-coalition may have an announcement of their own to preclude the former from reaching its epistemic goals. In this paper, we describe a PSPACE-complete model checking algorithm for CAL that produces winning strategies for coalitions. The algorithm is implemented in a proof-of-concept model checker.

scholarly journals Testing a proof of concept model for group couples counseling in family planning in Northern Uganda

2018 ◽  
Vol 30 ◽  
Author(s):  
Lillian Ojanduru ◽  
Dickens Ojamuge ◽  
Lauren DuComb ◽  
Jeannette Cachan ◽  
Esther Spindler
Keyword(s):  
Family Planning ◽  
Northern Uganda ◽  
Couples Counseling ◽  
Proof Of Concept ◽  
Concept Model

scholarly journals Are we predictive engines? Perils, prospects, and the puzzle of the porous perceiver

2013 ◽  
Vol 36 (3) ◽  
pp. 233-253 ◽  
Author(s):  
Andy Clark
Keyword(s):  
Predictive Processing ◽  
Cortical Processing ◽  
Target Article

AbstractThe target article sketched and explored a mechanism (action-oriented predictive processing) most plausibly associated with core forms of cortical processing. In assessing the attractions and pitfalls of the proposal we should keep that element distinct from larger, though interlocking, issues concerning the nature of adaptive organization in general.

scholarly journals Recent advances in managing gastrointestinal stromal tumor

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1689 ◽  
Author(s):  
Florence Duffaud ◽  
Axel Le Cesne
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Growth Factor Receptor ◽  
Standard Of Care ◽  
Platelet Derived Growth Factor ◽  
Proof Of Concept ◽  
Current Standard ◽  
Stromal Tumors ◽  
Concept Model ◽  
Activating Mutations ◽  
Effective Proof

Constitutive activating mutations inKITand platelet-derived growth factor receptor α (PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs.

Sign in / Sign up

Export Citation Format

Share Document