Assessment of Surgical Operations for Ductal Carcinoma In Situ of the Breast

1997 ◽  
Vol 13 (3) ◽  
pp. 420-429 ◽  
Author(s):  
Xi Peng Yin ◽  
Xiao Qing Li ◽  
Duncan Neuhauser ◽  
James T. Evans
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Clinical Studies ◽  
Surgical Procedure ◽  
Carcinoma In Situ ◽  
Breast Tissue ◽  
Ductal Carcinoma ◽  
Meta Analysis ◽  
Surgical Operations

AbstractThe choice of surgical procedure for the treatment of ductal carcinoma in situ (DCIS) remains clinically based. A meta-analysis was used to synthesize the results of 24 published clinical studies. Partial breast tissue excision appears to be as efficacious as mastectomy for the treatment of DCIS of the breast.

Axillary staging in ductal carcinoma in situ with microinvasion: A meta-analysis

2021 ◽  
pp. 101557
Author(s):  
Byung Choi ◽  
Lavandan Jegatheeswaran ◽  
Maria Nakhoul ◽  
Payal Haria ◽  
Reya Srivastava ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Meta Analysis ◽  
Axillary Staging

scholarly journals Is Carboxypeptidase B1 a Prognostic Marker for Ductal Carcinoma In Situ?

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1726
Author(s):  
Charu Kothari ◽  
Alisson Clemenceau ◽  
Geneviève Ouellette ◽  
Kaoutar Ennour-Idrissi ◽  
Annick Michaud ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Breast Tissue ◽  
Ductal Carcinoma ◽  
Mrna Level ◽  
Gene Signature ◽  
Low Grade ◽  
Tissue Samples ◽  
Ductal Hyperplasia

Ductal carcinoma in situ (DCIS) is considered a non-obligatory precursor for invasive ductal carcinoma (IDC). Around 70% of women with atypical ductal hyperplasia (ADH) undergo unnecessary surgery due to the difficulty in differentiating ADH from low-grade DCIS. If untreated, 14–60% of DCIS progress to IDC, highlighting the importance of identifying a DCIS gene signature. Human transcriptome data of breast tissue samples representing each step of BC progression were analyzed and high expression of carboxypeptidase B1 (CPB1) expression strongly correlated with DCIS. This was confirmed by quantitative PCR in breast tissue samples and cell lines model. High CPB1 expression correlated with better survival outcome, and mRNA level was highest in DCIS than DCIS adjacent to IDC and IDC. Moreover, loss of CPB1 in a DCIS cell line led to invasive properties associated with activation of HIF1α, FN1, STAT3 and SPP1 and downregulation of SFRP1 and OS9. The expression of CPB1 could predict 90.1% of DCIS in a cohort consisting of DCIS and IDC. We identified CPB1, a biomarker that helps differentiate DCIS from ADH or IDC and in predicting if a DCIS is likely to progress to IDC, thereby helping clinicians in their decisions.

scholarly journals Breast-conserving surgery with or without radiotherapy in women with ductal carcinoma in situ: a meta-analysis of randomized trials

2007 ◽  
Vol 2 (1) ◽  
Author(s):  
Gustavo A Viani ◽  
Eduardo J Stefano ◽  
Sérgio L Afonso ◽  
Lígia I De Fendi ◽  
Francisco V Soares ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Randomized Trials ◽  
Ductal Carcinoma ◽  
Meta Analysis ◽  
Breast Conserving Surgery
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