Temporal Lobe Epilepsy as a Unique Manifestation of Multiple Sclerosis

Objective:To report on five patients with temporal lobe epilepsy (TLE) as the unique manifestation of multiple sclerosis (MS).Methods:Among 350 consecutive MS patients, we identified 16/350 (4.6%) who also had epileptic seizures. Here, we review their electrophysiological and clinical features.Results:Five of these 16 patients (four female, one male; mean age 34.2 years; range 31 to 38) with MS and epileptic seizures had an extremely homogeneous clinical picture characterized by TLE as the unique manifestation of MS, even at long follow-up (mean: five years; range 4 to 10). In all patients, seizures started in the second or third decade. Brain MRI revealed at least one juxta-cortical lesion within the temporal region. Antiepileptic medication was always effective.Conclusions:The present study provides the first evidence of a peculiar form of MS characterized by TLE as the unique manifestation of the disease with no disability or MS relapses at long-term follow-up.

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Surgery for temporal lobe epilepsy associated with mesial temporal sclerosis in the older patient: A long-term follow-up

Epilepsia ◽

10.1111/j.1528-1167.2009.02430.x ◽

2010 ◽

Vol 51 (6) ◽

pp. 1024-1029 ◽

Cited By ~ 36

Author(s):

Michael Murphy ◽

Paul D. Smith ◽

Martin Wood ◽

Stephen Bowden ◽

Terence J. O’Brien ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Mesial Temporal Sclerosis ◽

Older Patient ◽

Long Term Follow Up

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Long-Term Neuropsychological Outcomes Following Temporal Lobe Epilepsy Surgery: An Update of the Literature

Healthcare ◽

10.3390/healthcare9091156 ◽

2021 ◽

Vol 9 (9) ◽

pp. 1156

Author(s):

Ioanna Alexandratou ◽

Panayiotis Patrikelis ◽

Lambros Messinis ◽

Athanasia Alexoudi ◽

Anastasia Verentzioti ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Neuropsychological Function ◽

Post Surgery ◽

Long Term Follow Up ◽

Neuropsychological Outcomes ◽

Selective Surgery

We present an update of the literature concerning long-term neuropsychological outcomes following surgery for refractory temporal lobe epilepsy (TLE). A thorough search was conducted through the PubMed and Medline electronic databases for studies investigating neuropsychological function in adult patients undergoing resective TLE surgery and followed for a mean/median > five years period. Two independent reviewers screened citations for eligibility and assessed relevant studies for the risk of bias. We found eleven studies fulfilling the above requirements. Cognitive function remained stable through long-term follow up despite immediate post-surgery decline; a negative relation between seizure control and memory impairment has emerged and a possible role of more selective surgery procedures is highlighted.

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Long-term follow-up of patients treated with glatiramer acetate: a multicentre, multinational extension of the European/Canadian double-blind, placebo-controlled, MRI-monitored trial

Multiple Sclerosis Journal ◽

10.1177/1352458506070704 ◽

2007 ◽

Vol 13 (4) ◽

pp. 502-508 ◽

Cited By ~ 39

Author(s):

M. Rovaris ◽

G. Comi ◽

MA Rocca ◽

P. Valsasina ◽

D. Ladkani ◽

...

Keyword(s):

Multiple Sclerosis ◽

Glatiramer Acetate ◽

Brain Mri ◽

Treatment Phase ◽

Double Blind ◽

Brain Volumes ◽

Disease Evolution ◽

Long Term Follow Up

Glatiramer acetate (GA) is effective in reducing clinical and magnetic resonance imaging (MRI) activity in relapsing-remitting multiple sclerosis (RRMS). Serial long-term MRI data are lacking for large cohorts of GA-treated patients. The European/Canadian GA study consisted of two consecutive phases, each lasting nine months. The first treatment phase was randomized, double-blind and placebo-controlled. The second was an open-label, active treatment phase with daily administration of 20 mg GA subcutaneously for all patients. For the long-term follow-up (LTFU), dual echo, pre- and postgadolinium T1-weighted brain MRI scans were obtained with the same acquisition scheme as for the original trial and a neurological assessment was performed. Lesion volumes, normalized brain volumes and percentage brain volume changes (PBVC) were measured. One hundred and forty-two (63.4%) of the 224 patients who completed the two phases of the European/Canadian study underwent the LTFU after a mean period of 5.8 years (range: 5.3-6.4); 73 were treated with GA from study initiation. MRI measures at LTFU did not significantly differ between patients originally assigned to placebo and those who were always treated with GA, but the proportion of patients who did not require walking aids at LTFU was lower in the latter group (P=0.034). PBVC between baseline and LTFU was significantly correlated with lesion load at study entry. An earlier initiation of GA treatment in patients with active RRMS might, at least partially, have a favourable impact on long-term disease evolution. Multiple Sclerosis 2007; 13: 502-508. http://msj.sagepub.com

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Surgical Treatment of Temporal Lobe Epilepsy–Long-Term Follow-up and Alteration of EEGs after Resection of Anterior Temporal Lobe

Psychiatry and Clinical Neurosciences ◽

10.1111/j.1440-1819.1982.tb00283.x ◽

1982 ◽

Vol 36 (3) ◽

pp. 263-265

Author(s):

Hirotsune Kawamura ◽

Keiichi Amano ◽

Tatsuya Tanikawa ◽

Hiroko Kawabatake ◽

Masao Notani ◽

...

Keyword(s):

Surgical Treatment ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Anterior Temporal Lobe ◽

Long Term Follow Up

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Long-Term Follow-Up of Ictal Asystole in Temporal Lobe Epilepsy: Is Permanent Pacemaker Therapy Needed?

Journal of Cardiovascular Electrophysiology ◽

10.1111/jce.13009 ◽

2016 ◽

Vol 27 (8) ◽

pp. 930-936 ◽

Cited By ~ 10

Author(s):

RITSUKO KOHNO ◽

HARUHIKO ABE ◽

NAOKI AKAMATSU ◽

DAVID G. BENDITT

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Permanent Pacemaker ◽

Pacemaker Therapy ◽

Long Term Follow Up

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Long term follow up of familial mesial temporal lobe epilepsy

Journal of Epilepsy and Clinical Neurophysiology ◽

10.1590/s1676-26492008000300006 ◽

2008 ◽

Vol 14 (3) ◽

pp. 111-113 ◽

Cited By ~ 1

Author(s):

Márcia E. Morita ◽

Lívia Conz ◽

Claudia V. Maurer-Morelli ◽

Eliane Kobayashi ◽

Clarissa L. Yasuda ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Mesial Temporal Lobe Epilepsy ◽

Seizure Outcome ◽

Asymptomatic Group ◽

Long Term Follow Up ◽

Mesial Temporal Lobe ◽

Asymptomatic Individuals ◽

One Year

OBJECTIVE: To analyze seizure outcome in individuals with familial mesial temporal lobe epilepsy (FMTLE). METHOD: We followed prospectively 64 individuals with FMTLE and 37 asymptomatic individuals belonging to 28 families. RESULTS: Patients with FMTLE had a mean follow up was 93.4 ± 15.8 months. At baseline they were divided in benign (n = 29), remission (n = 28) and refractory (n = 7). At last follow up visit 41.4% patients with benign FMTLE remained classified as benign, 20.7% became refractory and 37.9% were in remission. In the subgroup of FMTLE in remission 21 75% remained without seizures; 21.4% were classified as benign FMTLE, and one died (3.6%) from cause unrelated to epilepsy. All refractory patients remained refractory. From the asymptomatic group, 10.8% became symptomatic (FMTLE). The mean follow up was 76.0 ± 21.2 months. CONCLUSION: Prospective follow up of more than 7 years in patients with FMTLE revealed that it is unlikely to achieve seizure control in those with refractory seizures. Patients with diagnose of more benign forms of FMTLE for more than one year are likely to either remit or remain under well controlled seizures. The majority of patients who had achieved seizure remission remained seizure-free and none became refractory. Asymptomatic individuals had a greater probability to have seizures compared to the general population in a 6 year period of follow up.

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