scholarly journals The Anticonvulsant Effects of Vitamin E: A Further Evaluation

1992 ◽  
Vol 19 (2) ◽  
pp. 201-203 ◽  
Author(s):  
Sheldon L. Levy ◽  
W.M. Burnham ◽  
A. Bishai ◽  
Paul A. Hwang
Keyword(s):  
Vitamin E ◽  
Partial Epilepsy ◽  
Maximal Electroshock ◽  
Partial Seizures ◽  
Ferrous Chloride ◽  
Complex Partial Seizures ◽  
Complex Partial Epilepsy ◽  
Kindled Seizures ◽  
Standard Animal ◽  
Anticonvulsant Effects

ABSTRACT:Vitamin E (d-α-tocopherol) has proven to be a useful adjunct to anticonvulsant drugs in clinical studies. Improvement has occurred even in patients with complex partial seizures, which are often resistant to drug therapy. In animals, vitamin E is effective against ferrous chloride seizures, hyperbaric oxygen seizures and penicillin-induced seizures. It has failed, however, to show anticonvulsant effects in the standard animal models used for drug screening – the maximal electroshock and threshold pentylenetetrazol tests. The present experiments were designed to further explore the anti-epileptic actions of vitamin E in animals. Three models related to complex partial epilepsy were used: 1) the development of amygdala-kindled seizures; 2) the development of electrically-induced status in kindled animals; and 3) the development of kainic-acid seizures. Vitamin E failed to produce significant effects in any of the models.

scholarly journals Attentional disorders in patients with complex partial epilepsy

2003 ◽  
Vol 61 (2B) ◽  
pp. 335-338 ◽  
Author(s):  
Florindo Stella ◽  
Jayme Antunes Maciel
Keyword(s):  
State University ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Wrong Response ◽  
Significant Difference ◽  
Complex Partial Epilepsy ◽  
Epileptic Patients ◽  
Attentional Disorders ◽  
Comparative Group

A study of concentrated attention patterns in epileptic patients was conducted with the objectives: characterization of the patients' epileptic condition; assessment of the concentrated attention levels in epileptic and nonepileptic individuals; comparison of the attention levels of the two groups. An evaluation was performed of 50 adult outpatients with complex partial seizures and 20 non-epileptic individuals (comparative group) at the Neuroepilepsy Ambulatory Unit, State University of Campinas SP, Brazil. METHOD: characterization of seizure types, frequency and duration; concentrated attention assessment (Concentrated Attention Test - Toulouse-Piéron); comparison of the epileptic with non-epileptic individuals. RESULTS: A statistically significant difference was observed between the groups with regard to Correct Response, Wrong Response and No Response. A difference was observed in relation to Time, but it was statistically insignificant. The epileptic patients presented inferior cognitive performance in relation to concentrated attention when compared with the non-epileptic individuals, findings compatible with the clinical complaints.

scholarly journals A pilot study on benign partial epilepsy in children with complex partial seizures

Seizure ◽  
2001 ◽  
Vol 10 (3) ◽  
pp. 194-196 ◽  
Author(s):  
Yoshiko Ishiguro ◽  
Akihisa Okumura ◽  
Kazushi Nomura ◽  
Kazuyoshi Watanabe ◽  
Tamiko Negoro ◽  
...  
Keyword(s):  
Pilot Study ◽  
Partial Epilepsy ◽  
Partial Seizures ◽  
Complex Partial Seizures

scholarly journals Cysticidal therapy: impact on seizure control in epilepsy associated with neurocysticercosis

2000 ◽  
Vol 58 (4) ◽  
pp. 1014-1020 ◽  
Author(s):  
ISABEL CRISTINA DOS SANTOS ◽  
ELIANE KOBAYASHI ◽  
TÂNIA MARCHIORI CARDOSO ◽  
CARLOS ALBERTO MANTOVANI GUERREIRO ◽  
FERNANDO CENDES
Keyword(s):  
Seizure Control ◽  
Partial Epilepsy ◽  
Resonance Imaging ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Protein Levels ◽  
Elevated Protein ◽  
Imaging Results ◽  
The Mean ◽  
Electroencephalogram Eeg

OBJECTIVE: To evaluate the clinical features and seizure control of epilepsy related to neurocysticercosis. METHOD: 18 patients with partial epilepsy and neurocysticercosis were treated with albendazol or praziquantel and followed from 3 months to 12 years. We analyzed results from the CSF exam, interictal electroencephalogram (EEG), head computerized tomography and/or magnetic resonance imaging. RESULTS: The patients' mean age was 36.4 years. The mean duration of epilepsy was 16 years. 83% patients had simple partial seizures ; 17% had complex partial seizures . All patients underwent routine EEGs: 62% had abnormalities and 38% were normal. A relationship was observed between focal EEG abnormality and the location of cyst in 28% of the patients. The CSF exams showed pleocytosis in 33% of the patients, and 28% had elevated protein levels. Only 22% of patients had positive titer for cysticercosis in the CSF. In all patients who had somatosensory and special sensory seizures there was a relationship between location of the cysts and seizure semiology (n=11). After cysticidal therapy, 83% patients had a significant improvement in controlling seizures. CONCLUSION: In this group, we found a predominance of simple partial seizures and a relationship between somatosensory and special sensory seizures and the location of the cysts. Cysticidal therapy was effective in controlling seizures in these patients and should be considered for patients with partial seizures and semiology related to cyst location.

Benign partial epilepsy in infancy with complex partial seizures (Watanabe's syndrome): 12 non-Japanese new cases

1998 ◽  
Vol 20 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Giuseppe Capovilla ◽  
Lucio Giordano ◽  
Sandra Tiberti ◽  
Daniela Valseriati ◽  
Eugenio Menegati
Keyword(s):  
Partial Epilepsy ◽  
Partial Seizures ◽  
Complex Partial Seizures

Time Interval Between Traumatic Brain Injury And Post Traumatic Epilepsy

2013 ◽  
Vol 21 (2) ◽  
pp. 222-228
Author(s):  
Daniel Garbin Di Luca ◽  
Glenda Corrêa Borges de Lacerda
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
First Year ◽  
Time Interval ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Post Traumatic ◽  
Faster Development ◽  
Post Traumatic Epilepsy ◽  
Traumatic Epilepsy

Introduction. The estimated time interval in which an individual can develop Post Traumatic Epilepsy (PTE) after a traumatic brain injury (TBI) is not clear. Objective. To assess the possible influence of the clinical features in the time interval between TBI and PTE develop­ment. Method. We analyzed retrospectively 400 medical records from a tertiary Brazilian hospital. We selected and reevaluated 50 patients and data was confronted with the time between TBI and PTE devel­opment by a Kaplan-Meier survival analysis. A Cox-hazard regression was also conducted to define the characteristics that could be involved in the latent period of the PTE development. Results. Patients devel­oped PTE especially in the first year (56%). We found a tendency of a faster development of PTE in patients older than 24 years (P<0.0001) and in men (P=0.03). Complex partial seizures evolving to generalized seizures were predominant in patients after moderate (37.7%) and severe (48.8%) TBIs, and simple partial seizures evolving to general­ized seizures in mild TBIs (45.5%). Conclusions. Our data suggest that the first year after a TBI is the most critical period for PTE de­velopment and those males older than 24 years could have a faster development of PTE.

Postictal language dysfunction in complex partial seizures: Effect of contralateral ictal spread

Neurology ◽  
2001 ◽  
Vol 56 (11) ◽  
pp. 1590-1592 ◽  
Author(s):  
D. M. Ficker ◽  
R. Shukla ◽  
M. D. Privitera
Keyword(s):  
Partial Seizures ◽  
Complex Partial Seizures

Vagus nerve stimulation for complex partial seizures: surgical technique, safety, and efficacy

1993 ◽  
Vol 78 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Howard J. Landy ◽  
R. Eugene Ramsay ◽  
Jeremy Slater ◽  
Roy R. Casiano ◽  
Robert Morgan
Keyword(s):  
Vagus Nerve ◽  
Vocal Cord ◽  
Seizure Frequency ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Vocal Cord Dysfunction ◽  
High Current ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Stimulation Group

✓ Electrical stimulation of the vagus nerve has shown efficacy in controlling seizures in experimental models, and early clinical trials have suggested possible benefit in humans. Eleven patients with complex partial seizures were subjected to implantation of vagus nerve stimulators. Electrode contacts embedded in silicone rubber spirals were placed on the left vagus nerve in the low cervical area. A transcutaneously programmable stimulator module was placed in an infraclavicular subcutaneous pocket and connected to the electrode. One patient required replacement of the system due to electrode fracture. Another patient developed delayed ipsilateral vocal-cord paralysis; the technique was then modified to allow more tolerance for postoperative nerve edema. A third patient showed asymptomatic vocal-cord paresis on immediate postoperative laryngoscopy. Vagus nerve stimulation produces transient vocal-cord dysfunction while the current is on. Nine patients were randomly assigned to receive either high- or low-current stimulation, and seizure frequency was recorded. The high-current stimulation group showed a median reduction in seizure frequency of 27.7% compared to the preimplantation baseline, while the low-current stimulation group showed a median increase of 6.3%. This difference approached statistical significance. The entire population then received maximally tolerable stimulation. The high-current stimulation group showed a further 14.3% reduction, while the low-current stimulation group showed a 25.4% reduction compared to the blinded period. The efficacy of vagus nerve stimulation seemed to depend on stimulus parameters, and a cumulative effect was evident. These results are encouraging, and further study of this modality as an adjunct treatment for epilepsy is warranted.

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