Fragmentation of the Actin Filaments by Acute Pressure Overload to the Right Ventricle of the Conscious Dog.

1975 ◽  
Vol 33 ◽  
pp. 542-543
Author(s):  
Gerald E. Adomian ◽  
Michael M. Laks ◽  
H.J.C. Swan
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Main Pulmonary Artery ◽  
Pressure Overload ◽  
Muscle Length ◽  
In Vitro Study ◽  
Conscious Dog ◽  
Balloon Distension ◽  
The Right

We have postulated in a study of the isolated cat papillary muscle that the disparity between muscle length and sarcomere length may be the result of myofibrillar fragmentation. In contrast, Saphir and Karsner demonstrated in the rabbit myocardium subjected to an acute pressure overload, that segmentation or separation of intercalated discs occurred, and not myofibrillar fragmentation.In order to determine whether the myocardial fragmentation produced in the in vitro study has pathophysiological significance in the intact myocardium, tissues were studied from the right ventricle of the conscious dog subjected to an acute pressure overload.In order to produce the overload, we utilized a specially designed triple lumen pulmonary artery balloon distension catheter. This catheter can measure simultaneous pulmonary arterial and right ventricular pressures. The catheter was inserted through the jugular vein and wedged under flouroscopic control in a branch of the pulmonary artery. The balloon was situated in the main pulmonary artery.

scholarly journals P1591Assessment of flow disturbances in the right ventricle: an in vitro study using a novel heart model

EP Europace ◽  
2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii339-iii339
Author(s):  
U. Gulan ◽  
AM. Saguner ◽  
D. Akdis ◽  
C. Brunckhorst ◽  
M. Holzner ◽  
...  
Keyword(s):  
Right Ventricle ◽  
In Vitro Study ◽  
Vitro Study ◽  
Heart Model ◽  
Flow Disturbances ◽  
The Right

Absence of the coronary sinus with coronary venous drainage into the main pulmonary artery

2012 ◽  
Vol 23 (5) ◽  
pp. 759-762
Author(s):  
Kiyoshi Ogawa ◽  
Takashi Hishitani ◽  
Kenji Hoshino
Keyword(s):  
Coronary Angiography ◽  
Pulmonary Artery ◽  
Right Ventricle ◽  
Contrast Medium ◽  
Coronary Arteries ◽  
Coronary Sinus ◽  
Main Pulmonary Artery ◽  
Venous Drainage ◽  
Anterior Wall ◽  
The Right

AbstractWe describe the case of a 9-year-old girl demonstrating isolated absence of the coronary sinus with abnormal coronary venous drainage into the main pulmonary artery. Coronary angiography showed normal coronary arterial trees and contrast medium from both coronary arteries drained into the main pulmonary artery via an abnormal cardiac vein on the anterior wall of the right ventricle.

scholarly journals Clostridium septicum-induced gangrene in the right lower extremity complicating pneumatosis in the right ventricle and the pulmonary artery and occlusion of right femoral artery: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui-Dan Jing ◽  
Lei Li ◽  
Jun-Ying Tian ◽  
Dong-Po Jiang
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Femoral Artery ◽  
Treatment Success ◽  
Main Pulmonary Artery ◽  
Arterial Occlusion ◽  
Air Embolism ◽  
Gas Gangrene ◽  
Clostridium Septicum ◽  
The Right

Abstract Background Gas gangrene is usually manifested as myonecrosis and subcutaneous gas accumulation, but rarely manifested as arterial occlusion or pneumatosis in the right ventricle and the pulmonary artery. Case presentation We report a case of gas gangrene caused by Clostridium septicum. The patient developed gas gangrene after being pecked by a chicken but turned for the better following antibiotic treatment and debriment. Imaging test revealed a rare occlusion of the right femoral artery and pneumatosis in the right ventricle and the main pulmonary artery. Conclusions In the presence of gas gangrene, special care must be taken to prevent against the formation of circulatory air embolism. The gas gangrene-induced gangrene in the limb of this patient might be attributed to the combined action of infection and arterial occlusion. MDT (Multidisciplinary team)-Green Channel mode is conductive to treatment success of gas gangrene.

Anomalous origin of both pulmonary arteries from the ascending aorta with a nonbranching main pulmonary artery arising from the right ventricle

1990 ◽  
Vol 11 (3) ◽  
pp. 156-158 ◽  
Author(s):  
Hiroyuki Aotsuka ◽  
Yoko Nagai ◽  
Manabu Saito ◽  
Hiroo Matsumoto ◽  
Tsunetaro Nakamura
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Main Pulmonary Artery ◽  
Pulmonary Arteries ◽  
Ascending Aorta ◽  
Anomalous Origin ◽  
The Right

Efficiency and capacity of protein synthesis are increased in pressure overload cardiac hypertrophy

1988 ◽  
Vol 255 (2) ◽  
pp. H325-H328 ◽  
Author(s):  
R. Nagai ◽  
R. B. Low ◽  
W. S. Stirewalt ◽  
N. R. Alpert ◽  
R. Z. Litten
Keyword(s):  
Protein Synthesis ◽  
Pulmonary Artery ◽  
Cardiac Hypertrophy ◽  
Right Ventricle ◽  
Pressure Overload ◽  
Heart Weight ◽  
Rna Content ◽  
The Right ◽  
Pulmonary Artery Constriction

We measured the rate of protein synthesis and total RNA content in the right ventricle (RV) at day 2 and day 4 after pulmonary artery constriction to determine the contributions of changes in capacity and efficiency of in vivo protein synthesis to pressure overload (PO) cardiac hypertrophy. A significant increase in the proportion of RV weight to total heart weight was observed at day 2 and day 4 when compared with untreated controls. The rate of protein synthesis was significantly higher at day 2 post-PO (0.31 +/- 0.06 day-1 or 30 +/- 5 mg.g RV-1.day-1, means +/- SD, P less than 0.05) as well as at day 4 (0.25 +/- 0.05 day-1 or 28 +/- 9 mg.g RV-1.day-1, P less than 0.05) than for untreated rabbits (0.15 +/- 0.03 day-1 or 17 +/- 4 mg.g RV-1.day-1). RNA content was significantly higher at day 2 (1.47 +/- 0.17 mg/g RV, P less than 0.05) than in controls (1.16 +/- 0.14 mg/g RV), whereas there was a slight but nonsignificant increase at day 4 (1.36 +/- 0.21 mg/g RV, P less than 0.1). The efficiency of protein synthesis (synthesis/RNA) per gram RV was significantly increased both at day 2 (20.5 +/- 2.2 g protein.g RNA-1.day-1, P less than 0.05) and day 4 (19.8 +/- 3.5 g protein.g RNA-1.day-1, P less than 0.05) compared with control (14.6 +/- 2.3 g protein.g RNA-1.day-1). The increase in efficiency appeared to be caused by pressure overload itself based on a comparison of 0-4 day data vs. data obtained from sham animals (P less than 0.05).

scholarly journals Distinct right ventricle remodeling in response to pressure overload in the rat

2016 ◽  
Vol 311 (1) ◽  
pp. H85-H95 ◽  
Author(s):  
P. Mendes-Ferreira ◽  
D. Santos-Ribeiro ◽  
R. Adão ◽  
C. Maia-Rocha ◽  
M. Mendes-Ferreira ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Pulmonary Circulation ◽  
Pressure Overload ◽  
Experimental Models ◽  
Pulmonary Vasculature ◽  
Full Detail ◽  
Functional Changes ◽  
Systolic And Diastolic Function ◽  
The Right

Pulmonary arterial hypertension (PAH), the most serious chronic disorder of the pulmonary circulation, is characterized by pulmonary vasoconstriction and remodeling, resulting in increased afterload on the right ventricle (RV). In fact, RV function is the main determinant of prognosis in PAH. The most frequently used experimental models of PAH include monocrotaline- and chronic hypoxia-induced PAH, which primarily affect the pulmonary circulation. Alternatively, pulmonary artery banding (PAB) can be performed to achieve RV overload without affecting the pulmonary vasculature, allowing researchers to determine the RV-specific effects of their drugs/interventions. In this work, using two different degrees of pulmonary artery constriction, we characterize, in full detail, PAB-induced adaptive and maladaptive remodeling of the RV at 3 wk after PAB surgery. Our results show that application of a mild constriction resulted in adaptive hypertrophy of the RV, with preserved systolic and diastolic function, while application of a severe constriction resulted in maladaptive hypertrophy, with chamber dilation and systolic and diastolic dysfunction up to the isolated cardiomyocyte level. By applying two different degrees of constriction, we describe, for the first time, a reliable and short-duration PAB model in which RV adaptation can be distinguished at 3 wk after surgery. We characterize, in full detail, structural and functional changes of the RV in its response to moderate and severe constriction, allowing researchers to better study RV physiology and transition to dysfunction and failure, as well as to determine the effects of new therapies.

In-Vitro Pulsatile Flow Visualization Studies in a Pulmonary Artery Model

1985 ◽  
Vol 107 (4) ◽  
pp. 368-375 ◽  
Author(s):  
E. Philpot ◽  
A. P. Yoganathan ◽  
H.-W. Sung ◽  
Y.-R. Woo ◽  
R. H. Franch ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Flow Visualization ◽  
Pulsatile Flow ◽  
Main Pulmonary Artery ◽  
Pulmonary Arteries ◽  
Left Pulmonary Artery ◽  
Deceleration Phase ◽  
Right Pulmonary Artery ◽  
The Right

In-vitro pulsatile flow visualization studies were conducted in an adult-sized pulmonary artery model to observe the effects of valvular pulmonic stenosis on the flow fields of the main, left and right pulmonary arteries. The flow patterns revealed that as the degree of stenosis increased, the jet-type flow created by the valve became narrower, and it impinged on the far (distal) wall of the left pulmonary artery further downstream from the junction of the bifurcation. This in turn led to larger regions of disturbed turbulent flow, as well as helical-type secondary flow motions in the left pulmonary artery, compared to the right pulmonary artery. The flow field in the main pulmonary artery also became more disturbed and turbulent, especially during peak systole and the deceleration phase. The flow visualization observations have been valuable in helping to conduct further quantitative studies such as pressure and velocity field mapping. Such studies are important to understanding the fluid mechanics characteristics of the main pulmonary artery and its two major branches.

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