The Free Radical Theory of Aging: A Critique and Unresolved Questions

1992 ◽  
Vol 11 (3) ◽  
pp. 262-268 ◽  
Author(s):  
John C. Carlson ◽  
William F. Forbes
Keyword(s):  
Free Radical ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Compte Rendu ◽  
Radicaux Libres ◽  
Cycle De Vie ◽  
Theory Of Aging ◽  
Effets Biologiques

RÉSUMÉLa théorie des radicaux libres du vieillissement est très critiquée. Ce compte-rendu traite des effets biologiques des radicaux libres au cours du processus du vieillissement, de la relation entre le vieillissement et la maladie (comment ces deux concepts peuvent être affectés par les radicaux libres) et des effets des radicaux libres tout au long du cycle de vie. Cet article met en relief des aspects qui demandent une étude plus approfondie.

The Free Radical Theory of Aging and a Look at Changes in the Hypothalamus

1996 ◽  
Vol 15 (1) ◽  
pp. 44-53 ◽  
Author(s):  
J. C. Carlson ◽  
M. Sawada
Keyword(s):  
Free Radical ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Radicaux Libres ◽  
Theory Of Aging

RÉSUMÉSelon la théorie du radical libre, le vieillissement est produit par l'effet endommageant des radicaux d'oxygène. Ces radicaux sont produits de façon constante et deviennent toxiques quand le niveau de la concentration intracellulaire devient élevé. Malgré cet effet d'infamie, des études récentes indiquent qu'ils peuvent avoir un côté bénéfique en régulant certains mécanismes dans une cellule. Mais, avec le vieillissement, il semble que la capacité de réguler la concentration intracellulaire s'abaisse, et l'élévation du niveau devient toxique avec le temps. Il faut aussi examiner les effets endommageant des radicaux libres sur un niveau supérieur. À cause de la prééminence de l'hypothalamus comme centre régulateur homéostatique, il est possible que l'hypothalamus puisse jouer un rôle critique dans le processus de vieillissement. La perte progressive des fonctions dans ce centre peut mener à des changements systémiques qui peuvent provoquer des perturbations dans tout l'organisme.

scholarly journals A midlife crisis for the mitochondrial free radical theory of aging

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Jeffrey A Stuart ◽  
Lucas A Maddalena ◽  
Max Merilovich ◽  
Ellen L Robb
Keyword(s):  
Free Radical ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Midlife Crisis ◽  
Theory Of Aging

The inflammatory process in aging

2000 ◽  
Vol 10 (3) ◽  
pp. 207-222 ◽  
Author(s):  
Hae Young Chung ◽  
Hyon Jeen Kim ◽  
Kyung Jin Jung ◽  
Ji Sung Yoon ◽  
Mi Ae Yoo ◽  
...  
Keyword(s):  
Free Radical ◽  
Inflammatory Process ◽  
Redox State ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Functional Changes ◽  
Related Disease ◽  
Progressive Loss ◽  
Theory Of Aging ◽  
Aging Phenomena

Aging processes are time-dependent, deteriorative functional changes. These functional changes lead to a progressive loss of the organism’s ability to withstand both internal and environmental stresses, causing the failure of cellular homeostasis. Among the modern hypotheses, the ‘Oxidative Stress Hypothesis’ offers the best mechanistic elucidation of aging phenomena. Based on the ‘Free Radical Theory of Aging’, this hypothesis has gained popularity among researchers in the field of gerontology as well as other biomedical fields. Its primary premise proposes that aging and its related disease processes are the net result of free radical-induced damage, asserting further that an organism’s inability to produce counterbalancing antioxidative defences, i.e. defences that offset disturbances in the redox state, underlies its cause.

scholarly journals Oxidative Stress and Longevity in Okinawa: An Investigation of Blood Lipid Peroxidation and Tocopherol in Okinawan Centenarians

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Makoto Suzuki ◽  
D. Craig Willcox ◽  
Matthew W. Rosenbaum ◽  
Bradley J. Willcox
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Vitamin E ◽  
Age Groups ◽  
Plasma Lipid ◽  
Lipid Peroxide ◽  
Human Longevity ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Theory Of Aging

Background. The Free Radical Theory of Aging mechanistically links oxidative stress to aging. Okinawa has among the world's longest-lived populations but oxidative stress in this population has not been well characterized.Methods. We compared plasma lipid peroxide (LPO) and vitamin E—plasma and intracellular tocopherol levels (total α, β, and γ), in centenarians with younger controls.Results. Both LPO and vitamin E tocopherols were lower in centenarians, with the exception of intracellular β-tocopherol, which was significantly higher in centenarians versus younger controls. There were no significant differences between age groups for tocopherol: cholesterol and tocopherol: LPO ratios. Correlations were found between α-Tocopherol and LPO in septuagenarians but not in centenarians.Conclusions. The low plasma level of LPO in Okinawan centenarians, compared to younger controls, argues for protection against oxidative stress in the centenarian population and is consistent with the predictions of the Free Radical Theory of Aging. However, the present work does not strongly support a role for vitamin E in this phenomenon. The role of intracellular β-tocopherol deserves additional study. More research is needed on the contribution of oxidative stress and antioxidants to human longevity.

Free-Radical Theory of Aging

2013 ◽  
pp. 816-817
Author(s):  
Lindy Clemson ◽  
J. Rick Turner ◽  
J. Rick Turner ◽  
Farrah Jacquez ◽  
Whitney Raglin ◽  
...  
Keyword(s):  
Free Radical ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Theory Of Aging
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