Congenital malformations caused by psychotropic drugs in pregnancy

1994 ◽  
Vol 4 (4) ◽  
pp. 77-85
Author(s):  
G. de Cuypere ◽  
Ph. Rombaut ◽  
M. van Moffaert
Keyword(s):  
Valproic Acid ◽  
Side Effects ◽  
Psychotropic Drugs ◽  
Congenital Malformations ◽  
Epidemiological Studies ◽  
Teratogenic Effect ◽  
Teratogenic Effects ◽  
Harmful Effects ◽  
In Pregnancy

SummaryAfter a description of the harmful effects of psychotropic drugs as well as of the moments of vulnerability to any teratogenic effect, this paper reviews prospective, retrospective and epidemiological studies of the teratogenic effects of anticonvulsants (phenytoin, valproic acid, carbamazepine and barbiturates), lithium, anti-psychotics, benzodiazepines and anti-depressive agents. It is found that the results of these studies are not unequivocal. Only lithium and valproic acid are shown to be teratogenic. In cases where malformations of the fetus are observed, the treatment often consisted in a combination of various psychotropic drugs.The review is completed with data on the psychopharmacological problems during delivery and their side-effects on the newborn.

scholarly journals Maternal and neonatal complications during pregnancy in women with epilepsy

2016 ◽  
Vol 03 (02) ◽  
pp. 080-085
Author(s):  
R. Bansal ◽  
G. Jain ◽  
P. Kharbanda ◽  
M. Goyal ◽  
V. Suri
Keyword(s):  
Epidemiological Studies ◽  
Successful Management ◽  
Healthy Baby ◽  
Neonatal Complications ◽  
Neurological Problem ◽  
Harmful Effects ◽  
In Pregnancy

AbstractEpilepsy is the commonest serious neurological problem faced by obstetricians and gynaecologists. Epidemiological studies estimate epilepsy to complicate 0.3–0.7% of all pregnancies.1 2 The importance of epilepsy in pregnancy lies in the fact that many women with epilepsy (WWE) have to go through their pregnancy while taking antiepileptic (AED) drugs. Both the seizures and AEDs can have harmful effects on the mother as well the foetus. Thus, during pregnancy, the clinician faces dual challenge of controlling seizures as well as preventing teratogenicity of AEDs.1 In this review we discuss the possible impact of seizures as well as AEDs on mother as well as the child. We try to answer some of the commonest questions which are relevant to successful management of pregnancy and ensuring birth of a healthy baby.

Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations

2010 ◽  
Vol 362 (23) ◽  
pp. 2185-2193 ◽  
Author(s):  
Janneke Jentink ◽  
Maria A. Loane ◽  
Helen Dolk ◽  
Ingeborg Barisic ◽  
Ester Garne ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Congenital Malformations ◽  
Major Congenital Malformations ◽  
In Pregnancy

Teratogenic Effects of Maternal Coffee Consumption on Retinal Layers of Neonatal Mouse Eyes

1985 ◽  
Vol 43 ◽  
pp. 688-689
Author(s):  
K. S. Amankwah ◽  
A. D. Weberg ◽  
M. A. Gillott ◽  
R. C. Kaufmann
Keyword(s):  
Spontaneous Abortion ◽  
Congenital Malformations ◽  
Animal Studies ◽  
Fetal Death ◽  
Animal Experiments ◽  
Coffee Consumption ◽  
Teratogenic Effects ◽  
Retinal Layers ◽  
Maternal Consumption ◽  
Harmful Effects

Concern has been raised about the possible harmful effects upon the fetus of caffeine and freshly brewed coffee consumed during pregnancy. Caffeine has been linked to spontaneous abortion, small-for-dates babies, and congenital malformations in humans and to fetal resorption and fetal death in rodents. Animal studies with caffeine have demonstrated definite teratogenic effects upon fetuses exposed in utero. Caffeine and freshly brewed coffee have been used in animal experiments in which varied methods were employed to dose animals at specific gestational ages, but results from these studies proved inconclusive, particularly in regard to development of the eye. The current study, therefore, was undertaken to determine the effects, if any, of the maternal consumption of freshly brewed coffee upon the development of the retinal layers of the fetal eye.

Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations

2010 ◽  
Vol 65 (10) ◽  
pp. 619-620 ◽  
Author(s):  
Janneke Jentink ◽  
Maria A. Loane ◽  
Helen Dolk ◽  
Ingeborg Barisic ◽  
Ester Garne ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Congenital Malformations ◽  
Major Congenital Malformations ◽  
In Pregnancy

The Rational Use of Psychotropic Drugs in Pregnancy and Postpartum

1986 ◽  
Vol 31 (3) ◽  
pp. 183-190 ◽  
Author(s):  
Gail Erlick Robinson ◽  
Donna E. Stewart ◽  
Edred Flak
Keyword(s):  
Pregnant Woman ◽  
Psychotropic Medication ◽  
Psychotropic Drugs ◽  
Teratogenic Effects ◽  
Rational Use ◽  
Nursing Mother ◽  
Pregnancy And Postpartum ◽  
Withdrawal Effects ◽  
Breast Fed ◽  
In Pregnancy

When a pregnant woman or nursing mother requires psychotropic medication, one must consider the effect of such medications on the fetus or baby. The authors review the evidence for teratogenic effects of such drugs given during pregnancy, toxic or withdrawal effects in the newborn and dangers to the breast-fed baby. Suggestions are made for judicious use of psychotropic drugs in pregnant or nursing women.

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