scholarly journals Vaccine effectiveness for influenza in the elderly in welfare nursing homes during an influenza A (H3N2) epidemic

2000 ◽  
Vol 125 (2) ◽  
pp. 393-397 ◽  
Author(s):  
Y. DEGUCHI ◽  
Y. TAKASUGI ◽  
K. NISHIMURA
Keyword(s):  
Nursing Homes ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Hospital Admissions ◽  
Influenza Virus Infection ◽  
Severe Infection ◽  
The Elderly ◽  
Trivalent Influenza Vaccine ◽  
Homes For The Elderly ◽  
Vaccine Effect

Influenza vaccine effect on the occurrence and severity of influenza virus infection in a population residing in nursing homes for the elderly was studied as a cohort study during an influenza A (H3N2) epidemic in Japan. Of 22462 individuals living in 301 welfare nursing homes, 10739 voluntarily received inactivated, sub-unit trivalent influenza vaccine in a programme supported by the Osaka Prefectural Government. There were statistically significantly fewer cases of influenza, hospital admissions due to severe infection, and deaths due to influenza in the vaccinated cohort compared to the unvaccinated controls. No serious adverse reactions to vaccination were recorded. Thus influenza vaccination is effective for preventing influenza disease in persons aged 65 years and over, and should be an integral part of the care of this population residing in nursing homes.

scholarly journals High-dose trivalent influenza vaccine: safety and immunogenicity

2020 ◽  
Author(s):  
Raúl Ortiz de Lejarazu ◽  
◽  
Federico Martinón Torres ◽  
Ángel Gil de Miguel ◽  
Javier Díez Domingo ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Influenza Vaccine ◽  
Randomized Clinical Trials ◽  
Standard Dose ◽  
Meta Analysis ◽  
Influenza Virus Infection ◽  
The Elderly ◽  
The United States ◽  
High Dose ◽  
Trivalent Influenza Vaccine

Adults aged 65 years or older suffer the most severe health effects of seasonal flu. Although the influenza vaccine is effective in preventing influenza virus infection and its complications, it is not as effective in the elderly due to age-associated immunosenescence phenomenon. Since 2009, a high-dose trivalent influenza vaccine has been approved in the United States for the immunization of people ≥ 65 years with an antigen concentration four times higher than the standard vaccine. Multiple clinical trials carried out over different seasons, and using different methodologies, have shown that the high-dose trivalent influenza vaccine is not only more effective, but it also has a similar safety profile and is more immunogenic than the standard dose vaccine in the prevention of flu and its complications in the elderly. This document reviews the current scientific evidence on the safety and immunogenicity of high-dose influenza vaccine in people aged 65 years and over, and includes information from randomized clinical trials, observational studies with data from real clinical practice, and systematic reviews, and meta-analysis.

scholarly journals Load on the Low Back of Care Workers in Nursing Homes for the Elderly

2005 ◽  
Vol 47 (4) ◽  
pp. 131-138 ◽  
Author(s):  
Shinji Kumagai ◽  
Hidetsugu Tainaka ◽  
Keiko Miyajima ◽  
Naoko Miyano ◽  
Junko Kosaka ◽  
...  
Keyword(s):  
Nursing Homes ◽  
The Elderly ◽  
Low Back ◽  
Homes For The Elderly ◽  
Care Workers

scholarly journals Effectiveness of Influenza Vaccines in the HIVE household cohort over 8 years: is there evidence of indirect protection?

2021 ◽  
Author(s):  
Ryan E. Malosh ◽  
Joshua G. Petrie ◽  
Amy Callear ◽  
Rachel Truscon ◽  
Emileigh Johnson ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza A ◽  
Vaccine Coverage ◽  
Influenza Virus Infection ◽  
Influenza Vaccines ◽  
Mixed Effect ◽  
Vaccination Programs ◽  
Vaccine Recommendations ◽  
Influenza A H1n1 ◽  
Low Coverage

AbstractBackgroundThe evidence that influenza vaccination programs regularly provide protection to unvaccinated individuals (i.e. indirect effects) of a community is lacking. We sought to determine the direct, indirect, and total effects of influenza vaccine in the Household Influenza Vaccine Evaluation (HIVE) cohort.MethodsUsing longitudinal data from the HIVE cohort from 2010-11 through 2017-18, we estimated direct, indirect, and total influenza vaccine effectiveness (VE) and the incidence rate ratio of influenza virus infection using adjusted mixed-effect Poisson regression models. Total effectiveness was determined through comparison of vaccinated members of full or partially vaccinated households to unvaccinated individuals in completely unvaccinated households.ResultsThe pooled, direct VE against any influenza was 30.2% (14.0-43.4). Direct VE was higher for influenza A/H1N1 43.9% (3.9 to 63.5) and B 46.7% (17.2 to 57.5) than A/H3N2 31.7% (10.5 to 47.8); and was higher for young children 42.4% (10.1 to 63.0) than adults 18.6% (−6.3 to 37.7). Influenza incidence was highest in completely unvaccinated households (10.6 per 100 person-seasons) and lower at all other levels of household vaccine coverage. We found little evidence of indirect VE after adjusting for potential confounders. Total VET was 56.4% (30.1-72.9) in low coverage, 43.2% (19.5-59.9) in moderate coverage, and 33.0% (12.1 to 49.0) in fully vaccinated households.ConclusionInfluenza vaccines may have a benefit above and beyond the direct effect but that effect in this study was small. While there may be exceptions, the goal of global vaccine recommendations should remain focused on provision of documented, direct protection to those vaccinated.

scholarly journals REVEALING FEATURES OF THE ARCHITECTURAL TYPOLOGY OF NURSING HOMES

2020 ◽  
pp. 33-39
Author(s):  
I. Zhdanova ◽  
A. Kuznecova ◽  
P. Mihaylina
Keyword(s):  
Social Interaction ◽  
Nursing Homes ◽  
Functional Organization ◽  
The Elderly ◽  
Comfort Level ◽  
Functional Improvement ◽  
Foreign Experience ◽  
Homes For The Elderly ◽  
Care Health

The article focuses on the study of modern approaches in the typology of nursing homes. Global data on the increase in the share of older people in the total population are presented. In addition, Rosstat data confirm the relevance of studying this topic. Examples of foreign experience in designing and building homes for the elderly show the developed functional composition of the premises, along with the function of accommodation and care - health care, leisure, trade, sports, food and multifunctional spaces to ensure social interaction of different groups of the population. The research reveals a method of "functional improvement" aimed at developing optimal functional interactions between public and residential spaces. A concept project for a "dynamic" scheme has been developed, showing the inclusion of residential blocks in a multifunctional complex. The chosen functional organization allows the creation of private spaces for residents of retirement age and walking areas for visitors to the complex. It is determined that in Russia it is necessary to implement modern approaches adapted to Russian conditions, based on foreign experience. This will enhance the consumer quality of the facility and the comfort level of the elderly, which will undoubtedly provide social interaction through the introduction of educational and leisure functions, as well as improve the ecological and aesthetic qualities of the environment.

scholarly journals Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 704
Author(s):  
Laura Sánchez de Prada ◽  
Iván Sanz Muñoz ◽  
Javier Castrodeza Sanz ◽  
Raúl Ortiz de Lejarazu Leonardo ◽  
José María Eiros Bouza
Keyword(s):  
Influenza Vaccine ◽  
Influenza A ◽  
Seasonal Influenza ◽  
The Elderly ◽  
Antibody Responses ◽  
Serological Response ◽  
Serum Samples ◽  
H3n2 Subtype ◽  
Serological Studies ◽  
Vaccination Campaigns

Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vaccine (NAIV) in adults and the elderly and the adjuvanted influenza vaccine (AIV) in the elderly. Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vaccination during the 1996–2017 seasons. Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.

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