Neurodegenerative and psychiatric overlap in frontotemporal lobar degeneration: a case of familial frontotemporal dementia presenting with catatonia

2013 ◽  
Vol 26 (2) ◽  
pp. 345-347 ◽  
Author(s):  
Alvin C. Holm
Keyword(s):  
Traumatic Brain Injury ◽  
Frontotemporal Dementia ◽  
Frontotemporal Lobar Degeneration ◽  
Psychiatric Symptoms ◽  
Initial Response ◽  
Interpersonal Behavior ◽  
Detailed Family History ◽  
C9orf72 Mutation ◽  
Symptom Progression ◽  
Over Time

ABSTRACTThe behavioral variant of frontotemporal dementia (FTD) begins with psychiatric symptoms, including changes in personal conduct and/or interpersonal behavior. Prior to developing cognitive impairment, differentiating FTD from primary psychiatric disorders, like schizophrenia, can be challenging. This paper presents a case of traumatic brain injury with subsequent depression and catatonia. Initial response to electroconvulsive therapy and lorazepam suggested primarily psychiatric pathology. Subsequent symptom progression, reduced treatment response, and detailed family history evaluation led to the diagnosis of familial FTD with C9ORF72 mutation. This case highlights that familial FTD can present with depression with suicidal tendencies and catatonia, and that the responsiveness of these behavioral manifestations to standard therapies can change over time.

Clinical overlap between behavioral variant of frontotemporal dementia and bipolar disorder: A case report

2016 ◽  
Vol 33 (S1) ◽  
pp. S335-S336 ◽  
Author(s):  
P. Oliveira ◽  
C. Roque ◽  
V. Santos ◽  
N. Madeira
Keyword(s):  
Bipolar Disorder ◽  
Frontotemporal Dementia ◽  
Psychiatric Symptoms ◽  
Late Onset ◽  
Single Photon ◽  
Photon Emission ◽  
Interpersonal Behavior ◽  
Psychotic Symptoms ◽  
Emission Computed Tomography ◽  
Global Pattern

The behavioral variant of frontotemporal dementia (FTD) often begins with psychiatric symptoms, including changes in personal conduct and/or interpersonal behavior. Prior to developing cognitive impairment, differentiating FTD from primary psychiatric disorders might be challenging.This work presents a case of a manic episode with psychotic features in a 61-year-old man, whom personality changes and daily life difficulties arouse and persist after optimal management of the active manic and psychotic symptoms. Neuropsychological assessment detailed severe deficits among visuospatial and planning performances. Structural neuroimaging (CT-scan) primary revealed a global pattern of brain volume reduction. Severe perfusion deficits on frontal and both parietal lobes were shown on 99mTc-HMPAO single-photon emission computed tomography (SPECT). The hypothesis of probable FTD (behavioral variant) was established.The present case highlights how putative atypical and late-onset forms of bipolar disorder (BD) might instead progress to FTD. Several links are being advanced between the BD and FTD, for instance the close involvement of the C9ORF72 gene in a group of BD patients which progresses to dementia. These relations have actually been on focus recently. The field is however still relatively unexplored.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Apathy and Disinhibition Related to Neuropathology in Amnestic Versus Behavioral Dementias

2019 ◽  
Vol 34 (5) ◽  
pp. 337-343 ◽  
Author(s):  
Letizia G. Borges ◽  
Alfred W. Rademaker ◽  
Eileen H. Bigio ◽  
M-Marsel Mesulam ◽  
Sandra Weintraub
Keyword(s):  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Frontotemporal Lobar Degeneration ◽  
Neuropsychiatric Symptom ◽  
Retrospective Data ◽  
Alzheimer Type ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Dementia Severity ◽  
Over Time

Objectives: Investigating the frequency of apathy and disinhibition in patients clinically diagnosed with dementia of the Alzheimer type (DAT) or behavioral variant frontotemporal dementia (bvFTD) with neuropathology of either Alzheimer disease (AD) or frontotemporal lobar degeneration (FTLD). Methods: Retrospective data from 887 cases were analyzed, and the frequencies of apathy and disinhibition were compared at baseline and longitudinally in 4 groups: DAT/AD, DAT/FTLD, bvFTD/FTLD, and bvFTD/AD. Results: Apathy alone was more common in AD (33%) than FTLD (25%), and the combination of apathy and disinhibition was more common in FTLD (43%) than AD (14%; P < .0001). Over time, apathy became more frequent in AD with increasing dementia severity (33%-41%; P < .006). Conclusions: Alzheimer disease neuropathology had the closest association with the neuropsychiatric symptom of apathy, while FTLD was most associated with the combination of apathy and disinhibition. Over time, the frequency of those with apathy increased in both AD and FTLD neuropathology.

A male case of frontotemporal lobar degeneration with behavioural and psychiatric symptoms responding to a low dose of escitalopram

2021 ◽  
Author(s):  
Atsuko Ikenouchi ◽  
Issei Seki ◽  
Kei Takaoka ◽  
Naomichi Okamoto ◽  
Sayuri Murakami ◽  
...  
Keyword(s):  
Frontotemporal Lobar Degeneration ◽  
Low Dose ◽  
Psychiatric Symptoms

CHANGES IN THE OUTCOME OF PEDIATRIC PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY OVER TIME

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A101
Author(s):  
Kelly S Tieves ◽  
Cheryl A Muszynski ◽  
Bruce A Kaufman ◽  
Peter L Havens ◽  
Jayesh C Thakker
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Pediatric Patients ◽  
Over Time

Neurocognition, psychiatric symptoms, and lifetime homelessness among veterans with a history of traumatic brain injury

2019 ◽  
Vol 271 ◽  
pp. 167-170
Author(s):  
Elizabeth W. Twamley ◽  
Chelsea C. Hays ◽  
Ryan Van Patten ◽  
P. Michelle Seewald ◽  
Henry J. Orff ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Psychiatric Symptoms ◽  
History Of

scholarly journals Psychiatric effects of traumatic brain injury events in Cambodian survivors of mass violence

2002 ◽  
Vol 181 (4) ◽  
pp. 339-347 ◽  
Author(s):  
Richard F. Mollica ◽  
David C. Henderson ◽  
Svang Tor
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Injuries ◽  
Psychiatric Symptoms ◽  
Post Traumatic Stress ◽  
Mass Violence ◽  
Symptoms Of Depression ◽  
New Public Health ◽  
Multi Stage ◽  
Time Periods

BackgroundThe prevalence of brain injury and its effects in populations exposed to war violence has not been studied in recent years.AimsTo examine the association between traumatic brain injury events and psychiatric symptoms of major depression and post-traumatic stress disorder (PTSD) in Cambodian survivors of mass violence.MethodThe population comprised a multi-stage random sample of Cambodian refugees livingin a Thai refugee camp. The main results analysed the relationship between six categories of trauma events and psychiatric symptoms of depression and PTSD during two time periods.ResultsAlmost 15 000 trauma events were reported (n=13481, Pol Pot period; n=1249, past year). Traumatic brain injury was most common in the highly educated and in individuals with the highest levels of cumulative trauma. Of all trauma categories, traumatic brain injury revealed the strongest association with symptoms of depression, and a weaker association with PTSD. Brain injury represented 4% of the total number of traumatic events for both time periods, contributing 20% of the total symptom score for depression and 8% of that for PTSD.ConclusionsClinical identification and treatment of traumatic brain injuries in highly traumatised populations must be maintained in order to develop a new public health model for their treatment.

scholarly journals Very late-onset behavioral variant frontotemporal dementia

2013 ◽  
Vol 7 (1) ◽  
pp. 136-139
Author(s):  
Henrique Cerqueira Guimarães ◽  
Tatiana de Carvalho Espindola
Keyword(s):  
Case Report ◽  
Frontotemporal Dementia ◽  
Frontotemporal Lobar Degeneration ◽  
Clinical Presentation ◽  
Late Onset ◽  
Ground Level ◽  
Dementia Diagnosis ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Genetically Determined ◽  
Late Onset Dementia

ABSTRACT Current concepts regarding frontotemporal lobar degeneration (FTLD) have evolved rapidly in recent years. Genetically determined FTLD cohorts have broadened our knowledge pertaining to its clinical presentation, neuroimaging findings and demographics. In this study we present a case report of a patient diagnosed with behavioral variant frontotemporal dementia diagnosis in her nineties during hospital admission for a ground-level fall. We believe this case reinforces the pervasive nature of this clinical entity, and may contribute to an increased awareness of this diagnostic possibility in late-onset dementia.

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