Aberrant topographical organization in gray matter structural network in late life depression: a graph theoretical analysis

2013 ◽  
Vol 25 (12) ◽  
pp. 1929-1940 ◽  
Author(s):  
Hyun Kook Lim ◽  
Won Sang Jung ◽  
Howard J Aizenstein
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Networks ◽  
Small World ◽  
Late Life ◽  
Clustering Coefficient ◽  
Cingulate Gyrus ◽  
Late Life Depression ◽  
Matter Volume ◽  
Structural Brain

ABSTRACTBackground:Although previous studies on late life depression (LLD) have shown morphological abnormalities in frontal–striatal–temporal areas, alterations in coordinated patterns of structural brain networks in LLD are still poorly understood. The aim of this study was to investigate differences in gray matter structural brain network between LLD and healthy controls.Methods:We used gray matter volume measurement from magnetic resonance imaging to investigate large-scale structural brain networks in 37 LLD patients and 40 normal controls. Brain networks were constructed by thresholding gray matter volume correlation matrices of 90 regions and analyzed using graph theoretical approaches.Results:Although both LLD and control groups showed a small-world organization of group networks, there were no differences in the clustering coefficient, the path length, and the small-world index across a wide range of network density. Compared with controls, LLD patients showed decreased nodal betweenness in the medial orbitofrontal and angular gyrus regions. In addition, LLD patients showed hub regions in superior temporal gyrus and middle cingulate gyrus, and putamen. On the other hand, the control group showed hub regions in the medial orbitofrontal gyrus, middle cingulate gyrus, and cuneus.Conclusion:Our findings suggest that the gray matter structural networks are not globally but regionally altered in LLD patients. This multivariate structural analysis using graph theory might provide a more appropriate paradigm for understanding complicated neurobiological mechanism of LLD.

scholarly journals Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akihiro Takamiya ◽  
Thomas Vande Casteele ◽  
Michel Koole ◽  
François-Laurent De Winter ◽  
Filip Bouckaert ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Gray Matter ◽  
Memory Function ◽  
Gray Matter Volume ◽  
Verbal Learning ◽  
Late Life ◽  
Amyloid Deposition ◽  
Elderly Subjects ◽  
Late Life Depression ◽  
Matter Volume

AbstractLate-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role of AD-pathophysiology in LLD, and its association with clinical symptoms and cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission tomography (PET) imaging with [18F]-flutemetamol and structural MRI: 48 severely depressed elderly subjects (age 74.1 ± 7.5 years, 33 female) and 52 age-/gender-matched healthy controls (72.4 ± 6.4 years, 37 female). The Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) were used to assess the severity of depressive symptoms and episodic memory function respectively. Amyloid deposition was quantified using the standardized uptake value ratio. Whole-brain voxel-wise comparisons of amyloid deposition and gray matter volume (GMV) between LLD and controls were performed. Multivariate analysis of covariance was conducted to investigate the association of regional differences in amyloid deposition and GMV with clinical factors, including GDS and RAVLT. As a result, there were no significant group differences in amyloid deposition. In contrast, LLD showed significant lower GMV in the left temporal and parietal region. GMV reduction in the left temporal region was associated with episodic memory dysfunction, but not with depression severity. Regional GMV reduction was not associated with amyloid deposition. LLD is associated with lower GMV in regions that overlap with AD-pathophysiology, and which are associated with episodic memory function. The lack of corresponding associations with amyloid suggests that lower GMV driven by non-amyloid pathology may play a central role in the neurobiology of LLD presenting as a psychiatric disorder.Trial registration: European Union Drug Regulating Authorities Clinical Trials identifier: EudraCT 2009-018064-95.

scholarly journals P2-157: COGNITIVE TESTS AND GRAY MATTER VOLUME IN LATE LIFE DEPRESSION: A VOXEL-BASED MORPHOMETRY STUDY

2014 ◽  
Vol 10 ◽  
pp. P528-P529
Author(s):  
Salma Rose Imanari Ribeiz ◽  
Fabio Duran ◽  
Claudio Campi Castro ◽  
David Steffens ◽  
Geraldo Busatto ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Late Life ◽  
Cognitive Tests ◽  
Voxel Based Morphometry ◽  
Late Life Depression ◽  
Matter Volume

scholarly journals Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression

2021 ◽  
Author(s):  
Akihiro Takamiya ◽  
Thomas Vande Casteele ◽  
Michel Koole ◽  
François-Laurent De Winter ◽  
Filip Bouckaert ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Gray Matter ◽  
Memory Function ◽  
Gray Matter Volume ◽  
Verbal Learning ◽  
Late Life ◽  
Amyloid Deposition ◽  
Elderly Subjects ◽  
Late Life Depression ◽  
Matter Volume

AbstractLate-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role of AD-pathophysiology in LLD, and its association with clinical symptoms and cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission tomography (PET) imaging with [18F]-flutemetamol and structural MRI: 48 severely depressed elderly subjects (age 74.1±7.5 years, 33 female) and 52 age-/gender-matched healthy controls (72.4±6.4 years, 37 female). The Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) were used to assess the severity of depressive symptoms and episodic memory function respectively. Amyloid deposition was quantified using the standardized uptake value ratio. Whole-brain voxel-wise comparisons of amyloid deposition and gray matter volume (GMV) between LLD and controls were performed. Multivariate analysis of covariance was conducted to investigate the association of regional differences in amyloid deposition and GMV with clinical factors, including GDS and RAVLT. As a result, there were no significant group differences in amyloid deposition. In contrast, LLD showed significant lower GMV in the left temporal and parietal region. GMV reduction in the left temporal region was associated with episodic memory dysfunction, but not with depression severity. Regional GMV reduction was not associated with amyloid deposition. LLD is associated with lower GMV in regions that overlap with AD-pathophysiology, and which are associated with episodic memory function. The lack of corresponding associations with amyloid suggests that lower GM driven by non-amyloid pathology may play a central role in the neurobiology of LLD presenting as a psychiatric disorder.

Cortical metrics of the cingulate gyrus: Gray matter volume, area, and thickness derived from co-occurrence analysis

2003 ◽  
Vol 60 (1) ◽  
pp. 197-198
Author(s):  
M. Hosakere ◽  
J.T. Ratnanather ◽  
M.I. Miller ◽  
L. Wang ◽  
J.G. Csernansky
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Cingulate Gyrus ◽  
Matter Volume

Reduced gray matter volume in patients with retinal detachment: evidence from a voxel-based morphometry study

2019 ◽  
Vol 61 (3) ◽  
pp. 395-403
Author(s):  
Biao Li ◽  
Yu-Xin Liu ◽  
Hai-Jun Li ◽  
Qing Yuan ◽  
Pei-Wen Zhu ◽  
...  
Keyword(s):  
White Matter ◽  
Retinal Detachment ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Cingulate Gyrus ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Whole Brain ◽  
Matter Volume ◽  
Brain White Matter

Background We know little about the pathogenesis and diagnosis of retinal detachment. Purpose To assess spontaneous changes in the cerebral cortex of patients with retinal detachment using voxel-based morphometry and to explore the relationship between retinal detachment and clinical behavioral performance. Material and Methods Patients (14 men, 6 women; average age = 49.15 ± 10.32 years) with rhegmatogenous retinal detachment (duration of 24.05 ± 19.61 days) and 20 matched healthy controls were recruited. All participants underwent repeated functional magnetic resonance imaging scans. The original three-dimensional T1 brain images were analyzed using voxel-based morphometry and whole brain white matter volume and whole brain gray matter volume were compared with those of the control group. A receiver operating characteristic (ROC) curve was used to classify the mean gray matter volume values of the patients with retinal detachment compared with the controls. Results Compared with the controls, whole brain gray matter volume was significantly reduced in patients with retinal detachment, as evidenced by changes in the right inferior frontal gyrus, right superior temporal gyrus, right anterior cingulate gyrus, and right cuneus. In addition, the posterior lobe of the cerebellum, left hippocampus, left cingulate gyrus, and left middle temporal gyrus were also obviously atrophied. Furthermore, whole brain white matter volume of the patients with retinal detachment showed a slight reduction. The ROC curve analysis of each brain region showed that the accuracy of the area under the curve was high. Conclusion We proved that patients with retinal detachment had unusual changes in the gray matter volume and white matter volume in vision-related brain regions, which could reveal potential pathological mechanisms of retinal detachment.

scholarly journals T159. STRUCTURAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA IN ADVERSE ENVIRONMENTS: EXAMINING THE EFFECT OF POVERTY AND VIOLENCE IN SIX LATIN AMERICAN CITIES

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S291-S292
Author(s):  
Nicolas Crossley ◽  
Andre Zugman ◽  
Francisco Reyes-Madrigal ◽  
Leticia Czepielewski ◽  
Mariana Castro ◽  
...  
Keyword(s):  
Latin American ◽  
Gray Matter ◽  
Brain Structure ◽  
Gray Matter Volume ◽  
Healthy Controls ◽  
Middle Income ◽  
Middle Income Countries ◽  
Matter Volume ◽  
American Cities ◽  
Structural Brain

Abstract Background Social and environmental factors such as poverty or violence, modulate the risk and course of schizophrenia, but how they affect the brain in patients with psychosis remains unclear. We here studied how they are related to brain structure in schizophrenia and healthy controls in Latin America, where these factors are large and unequally distributed. Methods This is an MRI multi-center study in patients with schizophrenia and healthy controls from six Latin American cities: Buenos Aires, Medellin, Mexico City, Santiago, Sao Paulo and Porto Alegre. Total and voxel-level gray matter volumes obtained from T1-weighted MRI images and their relationship with income and homicide rates were analyzed using a general linear model. Results 334 patients with schizophrenia and 262 controls were included. Income was differentially related to total gray matter volume in the two groups (P=0.006). Controls showed a positive correlation between total gray matter volume and income (R=0.14, P=0.02). Surprisingly, this relationship was not present in schizophrenia (R=-0.076, P=0.17). Voxel-level analysis confirmed that this interaction was widespread across the cortex. After adjusting for global brain changes, income was positively related to prefrontal cortex volumes only in controls. Conversely, the hippocampus in patients, but not in controls, was relatively larger in affluent environments. There was no significant correlation between environmental violence and brain structure. Discussion Our results highlight the interplay between the environment, particularly poverty, and individual characteristics in psychosis. This is particularly important for harsh environments such as those from low and middle-income countries: potentially less brain vulnerability (less gray matter loss) is sufficient to become unwell in adverse (poor) environments. The development of algorithms exploring clinically-useful information from structural brain images in psychosis should include representative samples from low and middle-income countries.

scholarly journals Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume

2013 ◽  
Vol 14 (7) ◽  
pp. 663-675 ◽  
Author(s):  
Rachel F. Smallwood ◽  
Angela R. Laird ◽  
Amy E. Ramage ◽  
Amy L. Parkinson ◽  
Jeffrey Lewis ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Gray Matter ◽  
Meta Analysis ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Brain Anomalies ◽  
Structural Brain

scholarly journals Associations between age and gray matter volume in anatomical brain networks in middle‐aged to older adults

Aging Cell ◽  
2014 ◽  
Vol 13 (6) ◽  
pp. 1068-1074 ◽  
Author(s):  
Anne Hafkemeijer ◽  
Irmhild Altmann‐Schneider ◽  
Anton J. M. Craen ◽  
P. Eline Slagboom ◽  
Jeroen Grond ◽  
...  
Keyword(s):  
Older Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Networks ◽  
Middle Aged ◽  
Matter Volume
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