Association between change in brain gray matter volume, cognition, and depression severity: Pre- and post- antidepressant pharmacotherapy for late-life depression

ABSTRACTBackground:Although previous studies on late life depression (LLD) have shown morphological abnormalities in frontal–striatal–temporal areas, alterations in coordinated patterns of structural brain networks in LLD are still poorly understood. The aim of this study was to investigate differences in gray matter structural brain network between LLD and healthy controls.Methods:We used gray matter volume measurement from magnetic resonance imaging to investigate large-scale structural brain networks in 37 LLD patients and 40 normal controls. Brain networks were constructed by thresholding gray matter volume correlation matrices of 90 regions and analyzed using graph theoretical approaches.Results:Although both LLD and control groups showed a small-world organization of group networks, there were no differences in the clustering coefficient, the path length, and the small-world index across a wide range of network density. Compared with controls, LLD patients showed decreased nodal betweenness in the medial orbitofrontal and angular gyrus regions. In addition, LLD patients showed hub regions in superior temporal gyrus and middle cingulate gyrus, and putamen. On the other hand, the control group showed hub regions in the medial orbitofrontal gyrus, middle cingulate gyrus, and cuneus.Conclusion:Our findings suggest that the gray matter structural networks are not globally but regionally altered in LLD patients. This multivariate structural analysis using graph theory might provide a more appropriate paradigm for understanding complicated neurobiological mechanism of LLD.

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Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression

Scientific Reports ◽

10.1038/s41598-021-95206-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Akihiro Takamiya ◽

Thomas Vande Casteele ◽

Michel Koole ◽

François-Laurent De Winter ◽

Filip Bouckaert ◽

...

Keyword(s):

Episodic Memory ◽

Gray Matter ◽

Memory Function ◽

Gray Matter Volume ◽

Verbal Learning ◽

Late Life ◽

Amyloid Deposition ◽

Elderly Subjects ◽

Late Life Depression ◽

Matter Volume

AbstractLate-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role of AD-pathophysiology in LLD, and its association with clinical symptoms and cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission tomography (PET) imaging with [18F]-flutemetamol and structural MRI: 48 severely depressed elderly subjects (age 74.1 ± 7.5 years, 33 female) and 52 age-/gender-matched healthy controls (72.4 ± 6.4 years, 37 female). The Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) were used to assess the severity of depressive symptoms and episodic memory function respectively. Amyloid deposition was quantified using the standardized uptake value ratio. Whole-brain voxel-wise comparisons of amyloid deposition and gray matter volume (GMV) between LLD and controls were performed. Multivariate analysis of covariance was conducted to investigate the association of regional differences in amyloid deposition and GMV with clinical factors, including GDS and RAVLT. As a result, there were no significant group differences in amyloid deposition. In contrast, LLD showed significant lower GMV in the left temporal and parietal region. GMV reduction in the left temporal region was associated with episodic memory dysfunction, but not with depression severity. Regional GMV reduction was not associated with amyloid deposition. LLD is associated with lower GMV in regions that overlap with AD-pathophysiology, and which are associated with episodic memory function. The lack of corresponding associations with amyloid suggests that lower GMV driven by non-amyloid pathology may play a central role in the neurobiology of LLD presenting as a psychiatric disorder.Trial registration: European Union Drug Regulating Authorities Clinical Trials identifier: EudraCT 2009-018064-95.

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P2-157: COGNITIVE TESTS AND GRAY MATTER VOLUME IN LATE LIFE DEPRESSION: A VOXEL-BASED MORPHOMETRY STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2014.05.833 ◽

2014 ◽

Vol 10 ◽

pp. P528-P529

Author(s):

Salma Rose Imanari Ribeiz ◽

Fabio Duran ◽

Claudio Campi Castro ◽

David Steffens ◽

Geraldo Busatto ◽

...

Keyword(s):

Gray Matter ◽

Gray Matter Volume ◽

Late Life ◽

Cognitive Tests ◽

Voxel Based Morphometry ◽

Late Life Depression ◽

Matter Volume

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Comparison of regional gray matter volume abnormalities in Alzheimer׳s disease and late life depression with hippocampal atrophy using VSRAD analysis: A voxel-based morphometry study

Psychiatry Research Neuroimaging ◽

10.1016/j.pscychresns.2015.01.018 ◽

2015 ◽

Vol 232 (1) ◽

pp. 71-75 ◽

Cited By ~ 20

Author(s):

Kengo Shimoda ◽

Mahito Kimura ◽

Masami Yokota ◽

Yoshiro Okubo

Keyword(s):

Gray Matter ◽

Gray Matter Volume ◽

Late Life ◽

Hippocampal Atrophy ◽

Voxel Based Morphometry ◽

Late Life Depression ◽

Matter Volume

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Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression

10.1101/2021.02.08.21250568 ◽

2021 ◽

Author(s):

Akihiro Takamiya ◽

Thomas Vande Casteele ◽

Michel Koole ◽

François-Laurent De Winter ◽

Filip Bouckaert ◽

...

Keyword(s):

Episodic Memory ◽

Gray Matter ◽

Memory Function ◽

Gray Matter Volume ◽

Verbal Learning ◽

Late Life ◽

Amyloid Deposition ◽

Elderly Subjects ◽

Late Life Depression ◽

Matter Volume

AbstractLate-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role of AD-pathophysiology in LLD, and its association with clinical symptoms and cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission tomography (PET) imaging with [18F]-flutemetamol and structural MRI: 48 severely depressed elderly subjects (age 74.1±7.5 years, 33 female) and 52 age-/gender-matched healthy controls (72.4±6.4 years, 37 female). The Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) were used to assess the severity of depressive symptoms and episodic memory function respectively. Amyloid deposition was quantified using the standardized uptake value ratio. Whole-brain voxel-wise comparisons of amyloid deposition and gray matter volume (GMV) between LLD and controls were performed. Multivariate analysis of covariance was conducted to investigate the association of regional differences in amyloid deposition and GMV with clinical factors, including GDS and RAVLT. As a result, there were no significant group differences in amyloid deposition. In contrast, LLD showed significant lower GMV in the left temporal and parietal region. GMV reduction in the left temporal region was associated with episodic memory dysfunction, but not with depression severity. Regional GMV reduction was not associated with amyloid deposition. LLD is associated with lower GMV in regions that overlap with AD-pathophysiology, and which are associated with episodic memory function. The lack of corresponding associations with amyloid suggests that lower GM driven by non-amyloid pathology may play a central role in the neurobiology of LLD presenting as a psychiatric disorder.

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Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy

Journal of Alzheimer s Disease Reports ◽

10.3233/adr-170035 ◽

2017 ◽

Vol 1 (1) ◽

pp. 219-227 ◽

Cited By ~ 1

Author(s):

Shireen Sindi ◽

Ingemar Kåreholt ◽

Gabriela Spulber ◽

Hilkka Soininen ◽

Miia Kivipelto ◽

...

Keyword(s):

Gray Matter ◽

Gray Matter Volume ◽

Late Life ◽

Work Related Stress ◽

Work Related ◽

Matter Volume ◽

Related Stress

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Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults

10.1101/2021.09.15.460202 ◽

2021 ◽

Author(s):

Adriana Boettcher ◽

Alexis Zarucha ◽

Theresa Koebe ◽

Malo Gaubert ◽

Angela Hoeppner ◽

...

Keyword(s):

Older Adults ◽

Gray Matter ◽

Cognitive Abilities ◽

Gray Matter Volume ◽

Late Life ◽

Musical Instrument ◽

Brain Morphology ◽

Matter Volume ◽

Age Related ◽

Musical Activity

Regular musical activity as a highly-stimulating lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer's disease (AD). This study investigated associations between lifelong regular musical instrument playing, late-life cognitive abilities and brain morphology in older adults. We show that musical activity over the life course is associated with better global cognition, working memory, executive functions, language, and visuospatial abilities accounting for reserve proxies. Playing music is not significantly associated with gray matter volume in regions most affected by aging and AD. Selectively in the musically active participants, multi-domain cognitive abilities were enhanced with preserved gray matter volume in frontal and temporal regions. Our correlational findings suggest that playing a musical instrument may improve the recruitment of existing brain resources to facilitate late-life cognitive capacities. We propose that engaging in regular musical activity could serve as a low-threshold multimodal enrichment strategy that may promote cognitive resilience in advanced age.

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