Use of the Clock Drawing Task in the Diagnosis of Mild and Very Mild Alzheimer's Disease

1996 ◽  
Vol 8 (3) ◽  
pp. 469-476 ◽  
Author(s):  
Heidi Lee ◽  
Gregory R. J. Swanwick ◽  
Robert F. Coen ◽  
Brian A. Lawlor

The purpose of this study was to examine the utility of the clock drawing task (CDT) in differentiating between patients with mild and very mild Alzheimer's disease (AD) and normal controls. Thirty normal elderly individuals and 30 patients with probable AD were entered into the study and asked, in a standard fashion, to draw a clock from memory. All the clocks were scored according to two previously described standardized scoring systems, and the accuracy of classification into normal or AD groups was determined. Both CDT scales could discriminate between moderate AD and normal aging but lacked sensitivity in the very mild AD cases; mild cases showed intermediate sensitivity. In conclusion, the CDT as a test for AD is insensitive in the early-stage cases, but sensitivity improves with increasing severity of dementia. The CDT is unlikely to be useful in distinguishing between AD in its early stages and normal aging.

2013 ◽  
Vol 41 (6) ◽  
pp. 1233-1242 ◽  
Author(s):  
Joseph McBride ◽  
Xiaopeng Zhao ◽  
Nancy Munro ◽  
Charles Smith ◽  
Gregory Jicha ◽  
...  

2014 ◽  
Vol 10 ◽  
pp. P235-P236
Author(s):  
Hovagim Bakardjian ◽  
Harald Hampel ◽  
Michel Thiebaut de Schotten ◽  
Simone Lista ◽  
Stéphane Epelbaum ◽  
...  

2012 ◽  
Vol 8 (4S_Part_2) ◽  
pp. P46-P46
Author(s):  
Dong Young Lee ◽  
Jae Min Shon ◽  
Eun Hyun Seo ◽  
Bo Kyung Sohn ◽  
Jee Wook Kim ◽  
...  

2012 ◽  
Vol 8 (4S_Part_14) ◽  
pp. P519-P519
Author(s):  
Dong Young Lee ◽  
Jae Min Shon ◽  
Eun Hyun Seo ◽  
Bo Kyung Sohn ◽  
Jee Wook Kim ◽  
...  

Neuroscience ◽  
2013 ◽  
Vol 246 ◽  
pp. 271-280 ◽  
Author(s):  
J.M. Shon ◽  
D.Y. Lee ◽  
E.H. Seo ◽  
B.K. Sohn ◽  
J.W. Kim ◽  
...  

2011 ◽  
Vol 26 (8) ◽  
pp. 588-598 ◽  
Author(s):  
Khanh vinh quốc Lu’o’ng ◽  
Lan Thi Hoàng Nguyễn

Alzheimer’s disease (AD) is the most common form of dementia in elderly individuals and is associated with progressive neurodegeneration of the human neocortex. Thiamine levels and the activity of thiamine-dependent enzymes are reduced in the brains and peripheral tissues of patients with AD. Genetic studies have provided the opportunity to determine what proteins link thiamine to AD pathology (ie, transketolase, apolipoprotein E, α-1-antitrypsin, pyruvate dehydrogenase complex, p53, glycogen synthetase kinase-3β, c-Fos gene, the Sp1 promoter gene, and the poly(ADP-ribosyl) polymerase-1 gene). We reviewed the association between histopathogenesis and neurotransmitters to understand the relationship between thiamine and AD pathology. Oral thiamine trials have been shown to improve the cognitive function of patients with AD; however, absorption of thiamine is poor in elderly individuals. In the early stage of thiamine-deficient encephalopathy (Wernicke’s encephalopathy), however, parental thiamine has been used successfully. Therefore, further studies are needed to determine the benefits of using parental thiamine as a treatment for AD.


2010 ◽  
Vol 120 (5) ◽  
pp. 335-343 ◽  
Author(s):  
Randolph W. Parks ◽  
Subha N. Thiyagesh ◽  
Tom F. D. Farrow ◽  
Leanne Ingram ◽  
Katherine Wilkinson ◽  
...  

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