Recanalization of occluded modified Blalock–Taussig shunt using topical recombinant tissue plasminogen activator with balloon angioplasty

2004 ◽  
Vol 14 (3) ◽  
pp. 322-323 ◽  
Author(s):  
Kenji Suda ◽  
Masahiko Matsumura ◽  
Masahiko Matsumoto
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Balloon Angioplasty ◽  
Recombinant Tissue Plasminogen Activator ◽  
Tissue Plasminogen ◽  
Blalock Taussig Shunt

Catheter-induced acute Blalock–Taussig shunt thrombosis and bailout

2020 ◽  
Vol 30 (10) ◽  
pp. 1512-1514
Author(s):  
Bassel Mohammad Nijres ◽  
Paul M. Nelson ◽  
Joseph J. Vettukattil
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Balloon Angioplasty ◽  
Low Dose ◽  
Recombinant Tissue Plasminogen Activator ◽  
Shunt Thrombosis ◽  
Tissue Plasminogen ◽  
Life Threatening ◽  
Life Threatening Event ◽  
Blalock Taussig Shunt

AbstractModified Blalock–Taussig shunt thrombosis is a life-threatening event. We describe an extremely rare catheter-induced shunt thrombosis in an infant with complex CHD and its successful treatment utilising a single low dose of local recombinant tissue plasminogen activator in conjunction with balloon angioplasty.

scholarly journals Recombinant Tissue Plasminogen Activator Prevents Intimal Hyperplasia After Balloon Angioplasty in Hypercholesterolemic Rabbits

1996 ◽  
Vol 60 (11) ◽  
pp. 889-894 ◽  
Author(s):  
Ken Kanamasa ◽  
Norihiro Ishida ◽  
Hisaharu Kato ◽  
Shigeru Sakamoto ◽  
Takayuki Nakabayashi ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Balloon Angioplasty ◽  
Intimal Hyperplasia ◽  
Recombinant Tissue Plasminogen Activator ◽  
Tissue Plasminogen

Investigation by HPLC of the Catabolism of Recombinant Tissue Plasminogen Activator in the Rat

1988 ◽  
Vol 60 (01) ◽  
pp. 107-112 ◽  
Author(s):  
Roy Harris ◽  
Louis Garcia Frade ◽  
Lesley J Creighton ◽  
Paul S Gascoine ◽  
Maher M Alexandroni ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Half Life ◽  
Recombinant Tissue Plasminogen Activator ◽  
Rat Plasma ◽  
High Molecular Weight Complex ◽  
Molecular Weights ◽  
Major Activity ◽  
Tissue Plasminogen

SummaryThe catabolism of recombinant tissue plasminogen activator (rt-PA) was investigated after injection of radiolabelled material into rats. Both Iodogen and Chloramine T iodination procedures yielded similar biological activity loss in the resultant labelled rt-PA and had half lives in the rat circulation of 1 and 3 min respectively. Complex formation of rt-PA was investigated by HPLC gel exclusion (TSK G3000 SW) fractionation of rat plasma samples taken 1-2 min after 125I-rt-PA injection. A series of radiolabelled complexes of varying molecular weights were found. However, 60% of the counts were associated with a single large molecular weight complex (350–500 kDa) which was undetectable by immunologically based assays (ELISA and BIA) and showed only low activity with a functional promoter-type t-PA assay. Two major activity peaks in the HPLC fractions were associated with Tree t-PA and a complex having a molecular weight of ̴ 180 kDa. HPLC fractionation to produce these three peaks at various timed intervals after injection of 125I-rt-PA showed each to have a similar initial rate half life in the rat circulation of 4-5 min. The function of these complexes as yet is unclear but since a high proportion of rt-PA is associated with a high molecular weight complex with a short half life in the rat, we suggest that the formation of this complex may be a mechanism by which t-PA activity is initially regulated and finally cleared from the rat circulation.

Bioavailability in Rats of Human Recombinant Tissue Plasminogen Activator After Subcutaneous and Intramuscular Injection

1986 ◽  
Vol 56 (03) ◽  
pp. 299-301 ◽  
Author(s):  
L J Garcia Frade ◽  
S Poole ◽  
S Hanley ◽  
L J Creighton ◽  
A D Curtis ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Inferior Vena ◽  
Peak Plasma ◽  
Plasma Concentrations ◽  
Vena Cava ◽  
Recombinant Tissue Plasminogen Activator ◽  
Fibrin Plate ◽  
Tissue Plasminogen

SummaryThe bioavailability of human recombinant tissue plasminogen activator (rt-PA) in rats was measured after subcutaneous (s.c.) and intramuscular (i.m.) injection. Rt-PA was absorbed after both i.m. and s.c. injection, giving peak plasma concentrations within 30 min and 1 h, respectively, with detectable concentrations up to 6 h. These peak values of bioavailable t-PA were obtained in a functional fibrin plate assay of euglobulin precipitates and expressed as +88% and +243% (for s.c. and i.m. routes respectively) above basal rat fibrinolytic activity. Prior injection of rt-PA, s.c. or i.m., significantly reduced the weights of thrombi induced in the inferior vena cava after injection.

Sign in / Sign up

Export Citation Format

Share Document