Significance of red cell distribution width in the differential diagnosis between neurally mediated syncope and arrhythmic syncope in children

2016 ◽  
Vol 27 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Qingyou Zhang ◽  
Yaqi Li ◽  
Ying Liao ◽  
Junbao Du
Keyword(s):  
Receiver Operating Characteristic Curve ◽  
Predictive Value ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Neurally Mediated Syncope ◽  
Operating Characteristic Curve

AbstractObjectivesThe aim of the present study was to explore the predictive value of red cell distribution width as a means to differentiate between neurally mediated syncope and arrhythmic syncope in children.MethodPatients were divided into a neurally mediated syncope group (n=72) and an arrhythmic syncope group (n=21) on the basis of clinical history, results of the head-up tilt test, electrocardiography, and 24-hour ambulatory electrocardiography. As controls, we recruited 55 healthy children. Red cell distribution width was determined for children in all groups. A receiver operating characteristic curve was drawn to study the predictive effect of red cell distribution width to differentiate between neurally mediated syncope and arrhythmic syncope.ResultsRed cell distribution width was significantly higher in children with neurally mediated syncope than in children with arrhythmic syncope and the control group. A receiver operating characteristic curve on the predictive value of red cell distribution width in differentiating neurally mediated syncope from arrhythmic syncope showed that the area under the curve was 0.841 (95% confidence interval: 0.737–0.945, p<0.05). A red cell distribution width value of 12.8% as the cut-off value yielded a sensitivity of 80.6% and a specificity of 76.2% in discriminating between patients with neurally mediated syncope and arrhythmic syncope.ConclusionRed cell distribution width value of ⩾12.8% might be a useful adjunct for primary-care physicians to differentiate neurally mediated syncope from arrhythmic syncope in children.

Red cell distribution width to platelet ratio (RPR) predicts liver fibrosis in patients with autoimmune hepatitis

2019 ◽  
Author(s):  
Huali Wang ◽  
Jian Wang ◽  
Juan Xia ◽  
Xiaomin Yan ◽  
Yanhong Feng ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Autoimmune Hepatitis ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Advanced Fibrosis ◽  
Distribution Width ◽  
Operating Characteristic Curve

Abstract Background Accurately evaluate the stages of liver fibrosis are critical for the management of patients with autoimmune hepatitis (AIH). We evaluated the accuracy of red cell distribution width (RDW) to platelet (PLT) ratio (RPR) in predicting liver fibrosis in AIH patients.Methods One hundred and nineteen AIH patients with liver biopsy was retrospectively enrolled. Scheuer scoring system was used to stage liver fibrosis. Receiver operating characteristic curve (AUROC) was performed to evaluate the diagnostic accuracy of RPR.Results The median RPR values were 0.10, 0.10 and 0.14 for AIH patients with S2-S4, S3-S4 and S4, which were significantly higher than patients with S0-S1 (0.07, P<0.001), S0-S2 (0.08, P=0.025) and S0-S3 (0.09, P=0.014), respectively. The RPR levels were positively associated with the fibrosis stages (r=0.412, P<0.001), whereas there were no associations between liver fibrosis stages and aspartate transaminase to platelet ratio index (APRI) and fibrosis-4 score (FIB-4). The AUROCs of RPR were 0.780 (95%CI 0.696 to 0.865), 0.639 (95%CI 0.530 to 0.748) and 0.724 (95%CI 0.570 to 0.878) in diagnosing significant fibrosis (S2-S4), advanced fibrosis (S3-S4) and cirrhosis (S4) for AIH patients, respectively. The AUROCs of RPR were significantly higher than those of APRI and FIB-4 in staging liver fibrosis for AIH patients.Conclusion RPR is a simple predictor of liver fibrosis and is superior to APRI and FIB-4 in identifying liver fibrosis in AIH patients.

scholarly journals Incremental Predictive Value of Red Cell Distribution Width for 12-Month Clinical Outcome After Acute Myocardial Infarction

2013 ◽  
Vol 36 (6) ◽  
pp. 336-341 ◽  
Author(s):  
Jang Hoon Lee ◽  
Dong Heon Yang ◽  
Se Yong Jang ◽  
Won Suk Choi ◽  
Kyun Hee Kim ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Outcome ◽  
Predictive Value ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

scholarly journals Predictive value of a novel lncRNA LINC02518 in evaluating the prognosis of patients with hepatocellular carcinoma

2021 ◽  
Author(s):  
Wei Cui ◽  
Jingzhi Huang ◽  
Ruiqi Wang ◽  
Yu Wang ◽  
Xiaoming Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Receiver Operating Characteristic Curve ◽  
Receiver Operating Characteristic ◽  
Predictive Value ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Operating Characteristic Curve ◽  
Receiver Operating

Aim: The potential of long noncoding RNA in hepatocellular carcinoma (HCC) has led to promising insights into therapeutic intervention. The clinical significance of LINC02518 in HCC is unclear. This study aimed to evaluate the predictive value of a novel long noncoding RNA, LINC02518, for the prognosis of patients with HCC. Methods: Between December 2005 and November 2011, 125 and 75 HCC patients in the training and validation groups, respectively, who underwent liver surgery were included in our study. The LINC02518 expression of HCC and corresponding nontumor liver tissues was detected using microarray and reverse transcription quantitative polymerase chain reaction (RT-qPCR). These HCC patients were assigned into high and low LINC02518 expression groups based on the threshold of the receiver operating characteristic curve. Kaplan-Meier analysis was performed to determine the prognosis of HCC patients. Results: LINC02518 expression was upregulated in paired tumor samples compared with corresponding nontumor samples in the two groups. The area under the receiver operating characteristic curve for the levels of LINC02518 in the diagnosis of HCC was 0.66, 95% CI: 0.59–0.73. HCC patients with high LINC02518 expression had significantly worse tumor recurrence-free, metastasis-free, disease-free and overall survival than those with low LINC02518 expression. Conclusion: LINC02518 is negatively correlated with the prognosis of HCC and provides a promising strategy for the treatment and prognosis of HCC.

scholarly journals The predictive value of red cell distribution width for stroke severity and outcome

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Kavous Shahsavarinia ◽  
Younes Ghavam Laleh ◽  
Payman Moharramzadeh ◽  
Mahboob Pouraghaei ◽  
Elyar Sadeghi-Hokmabadi ◽  
...  
Keyword(s):  
Predictive Value ◽  
Red Cell Distribution Width ◽  
Stroke Severity ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width

scholarly journals Usefulness of the 5MPB-Toledo model to predict bacteremia in patients with community-acquired pneumonia in the Emergency Department

2021 ◽  
Author(s):  
Agustín Julián-Jiménez ◽  
◽  
Juan González del Castillo ◽  
Eric Jorge García-Lamberechts ◽  
Rafael Rubio Díaz ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Receiver Operating Characteristic Curve ◽  
Receiver Operating Characteristic ◽  
Predictive Value ◽  
Emergency Departments ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Community Acquired Pneumonia ◽  
Prognostic Performance ◽  
Operating Characteristic Curve

Objective. To analyse a new risk score to predict bacteremia in the patients with Community-acquired Pneumonia (CAP) in the emergency departments. Patients and methods. Prospective and multicenter observational cohort study of the blood cultures ordered in 74 Spanish emergency departments for patients with CAP seen from November 1, 2019, to March 31, 2020. The predictive ability of the model was analyzed with the area under the Receiver Operating Characteristic curve (AUC-ROC). The prognostic performance for true bacteremia was calculated with the chosen cut-off for getting the sensitivity, specificity, positive predictive value and negative predictive value. Results. A total of 1,020 blood samples wered cultured. True cases of bacteremia were confirmed in 162 (15.9%). The remaining 858 cultures (84.1%) wered negative. And, 59 (5.8%) were judged to be contaminated. The model´s area under the receiver operating characteristic curve was 0.915 (95% CI, 0.898-0.933). The prognostic performance with a model´s cut-off value of ≥ 5 points achieved 97.5% (95% CI, 95.1-99.9) sensitivity, 73.2% (95% CI, 70.2-76.2) specificity, 40.9% (95% CI, 36.4-45.1) positive predictive value and 99.4% (95% CI, 99.1-99.8) negative predictive value. Conclusion. The 5MPB-Toledo score is useful for predicting bacteremia in the patients with CAP seen in the emergency departments.

scholarly journals PERAN RED CELL DISTRIBUTION WIDTH SEBAGAI PREDIKTOR MORTALITAS PADA PASIEN SEPSIS DAN SYOK SEPTIK

2019 ◽  
pp. 70-78
Author(s):  
Fonda Silalahi ◽  
Reno Budiman ◽  
Kiki A Rizky
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Receiver Operating

Red cell Distribution Width (RDW) adalah parameter hematologis yang sederhana dan rutin diperiksa sebagai bagian pemeriksaan darah lengkap. Berbagai penelitian dan teori menghubungkan nilai RDW sebagai faktor prediktor mortalitas pada penyakit kritis dan juga sepsis. Tujuan dari penelitian ini adalah untuk mengetahui peran RDW sebagai prediktor kejadian mortalitas pada pasien sepsis dan syok septik. Penelitian dilakukan dengan metode prospektif terhadap 51 pasien dewasa dengan sepsis dan syok septik di Instalasi Gawat Darurat dan Instalasi Perawatan Intensif Rumah Sakit Umum Pusat (RSUP) Hasan Sadikin periode September 2017 sampai dengan Agustus 2018. Pemeriksaan RDW pada pasien diambil setelah diagnosis sepsis dan syok septik ditegakkan dan dilakukan observasi selama 30 hari. Terdapat 51 subyek penelitian dengan rerata usia 54,39 tahun. Rasio perbandingan pria : wanita adalah 1,55 : 1. Nilai median RDW adalah 19,1%. Nilai RDW tertinggi adalah 27,68% sedangkan nilai RDW terendah adalah 14,18%. Hasil analisis kurva Receiver Operating Characteristic (ROC) didapatkan cut off point pada nilai RDW 18,55% ( RDW>18,55% dan RDW<18,55%) mempunyai hubungan bermakna untuk memprediksi terjadinya mortalitas. RDW dapat dijadikan prediktor untuk kejadian mortalitas pada pasien sepsis dan syok septik.

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