The Impact of Mood Stabilizers on Suicide in Bipolar Disorder: A Comparative Analysis

CNS Spectrums ◽  
2000 ◽  
Vol 5 (S1) ◽  
pp. 12-18 ◽  
Author(s):  
Frederick K. Goodwin ◽  
S. Nassir Ghaemi

AbstractWhich mood stabilizers are the most effective in reducing suicide rates in patients with bipolar disorder? This paper reviews the literature and compares the data on two types of mood-stabilizing agents, lithium and anticonvulsants. Compared with the large amount of data on lithium, there is surprising little information available on the effects of anticonvulsants on mortality in manic-depressive illness. Each was also assessed in terms of suicide risk factors such as depression and mixed episodes, rapid cycling, substance abuse, anxiety and panic, and central serotonergic function. Only two studies that provide data demonstrating anticonvulsant efficacy in preventing suicide in bipolar disorder are available, and the data are incomplete at best. Further research in this area should include an emphasis on the outcome of mortality in patients treated with any of the anticonvulsants or with lithium-anticonvulsant combinations.

Author(s):  
Paul Harrison ◽  
Philip Cowen ◽  
Tom Burns ◽  
Mina Fazel

‘Bipolar disorder’ provides an account of the clinical and scientific aspects of bipolar disorder (‘manic depressive illness’). Identification of varying degrees of mood elevation is critical to the diagnosis of bipolar disorder to allow its distinction from unipolar depression, and the phenomenology and classification of manic states is described in detail. The range of aetiological factors involved in the development of bipolar illness is covered, from genetics and brain structure to psychology and life events. The efficacy of treatments both psychological and pharmacological in bipolar disorder is assessed, including new approaches with psychoeducation, atypical antipsychotic drugs, and anticonvulsant mood stabilizers. An additional section covers the clinically challenging treatment of bipolar depression. The evidence from clinical trials is then placed in the context of good clinical management of both the acute phases of bipolar illness as well as longer-term maintenance treatment.


1992 ◽  
Vol 9 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Patrick McKeon ◽  
Patrick Manley ◽  
Gregory Swanwick

AbstractThe treatment outcome of 100 bipolar disorder patients (B.P.) was examined retrospectively to determine whether bipolar subtypes had a differential prophylactic response to lithium, carbamazepine, neuroleptics and antidepressant drugs when these treatments were given in a predetermined sequence. Sixty-eight per cent of 53 B.P.-I patients with a mania-depression-normothymic-interval (M.D.I.) sequence of mood changes had a good response to lithium, and all but one of the remainder responded with the addition of carbamazepine or an antidepressant. While only 17% of 12 unipolar manic patients achieved prophylaxis with lithium and a further 17% when carbamazepine was added, the other 66% remained normothymic when a neuroleptic was prescribed with lithium. Of the seven rapid cycling patients where depression preceded mania, 28% had a good prophylactic effect with lithium, a further 28% when a tricyclic antidepressant was added and 14% with lithium and carbamazepine. None of the 18 rapid cycling M.D.I. group had a good response to lithium, but 39% stabilised when carbamazepine was added to lithium. Twenty-eight per cent of this group failed completely to respond to any of the treatments used. Neuroleptics increased the severity and duration of depressive phases for all subtypes except the unipolar mania group.


Author(s):  
Max Fink MD

Patients suffering from mania are overactive, intrusive, excited, and belligerent. They may believe that they have special powers, are related to public figures, and can read the minds of others. They spend money lavishly. Voices on the radio or television are sometimes understood as personal communications. They speak rapidly, with illogical and confused thoughts, move constantly, and write page after page of nonsense. They typically sleep and eat poorly, have little interest in work, friends, or family, and often require restraint or seclusion. Suicide is a perpetual threat. Some manic patients are likable, while others are angry and frightening. Psychosis is a frequent feature. Manic patients believe that their parents are not their real parents, asserting that they have royal blood. They believe that they can predict the future. They know that others are watching or talking about them, and they hear voices when no one is present. Delusional mania requires more intensive treatment and almost always hospital care. In older classifications of psychiatric illnesses, these patients were considered to be suffering from a manic-depressive illness. In modern classification, this term has been discarded and the illness is now conceived as bipolar disorder for patients with manic and depressive features and major depression for those with depressive symptoms only. Bipolar disorders, ranging from mild to severe, are divided into numerous subtypes. The variety of symptoms that admit the diagnosis of bipolar disorder has led to a virtual epidemic of diagnoses of the condition. Many patients so labeled do not exhibit the sleep difficulty, loss of appetite, and loss of weight, or the severity of illness, that were the criteria for manic-depressive illness. In manic-depressive illness, the manic episode persists for hours, days, weeks, or months and interferes with normal living. Once the episode resolves, it may suddenly recur; or manic episodes may alternate with periods of depression, or occur as simultaneous mixed episodes of depression and mania. When the shift in mood from mania to depression takes place within one or a few days, the condition is labeled rapid cycling, a particularly malignant form of the illness. In manic-depressive illness, the manic episode persists for hours, days, weeks, or months and interferes with normal living.


1994 ◽  
Vol 40 (2) ◽  
pp. 303-308 ◽  
Author(s):  
B J Carroll

Abstract Manic depressive illness (bipolar disorder) is the mood disorder classically considered to have a strong biological basis. During manic depressive cycles, patients show dramatic fluctuations of mood, energy, activity, information processing, and behaviors. Theories of brain function and mood disorders must deal with the case of bipolar disorder, not simply unipolar depression. Shifts in the nosologic concepts of how manic depression is related to other mood disorders are discussed in this overview, and the renewed adoption of the Kraepelinian "spectrum" concept is recommended. The variable clinical presentations of manic depressive illness are emphasized. New genetic mechanisms that must be considered as candidate factors in relation to this phenotypic heterogeneity are discussed. Finally, the correlation of clinical symptom clusters with brain systems is considered in the context of a three-component model of manic depression.


Author(s):  
Patricia Moran

This chapter discusses White’s illness within the context of medical and subjective accounts of bipolar disorder. It opens with a selective overview of White’s life that highlights the key sites of disruption and signs of illness. It then turns to an overview of manic-depressive illness, followed by a more detailed description of the characteristics of manic, depressive and mixed episodes. It ends with a brief comparison of White’s experiences of illness to those of her contemporary Virginia Woolf. This comparison demonstrates not only the diverse expressions of manic-depressive illness but also the different approaches that the writers themselves as well as family members adopted to cope with it.


1986 ◽  
Vol 15 (4) ◽  
pp. 365-369 ◽  
Author(s):  
Arthur Lazarus

A case of factitious disorder with physical symptoms is described in a patient with manic-depressive illness. The coexistence of factitious disorder and bipolar disorder has not been previously reported. Clinicians should search for an underlying affective disorder in patients who fabricate signs and symptoms of physical illness, since mania may simulate or contribute to the production of factitious behavior.


2018 ◽  
pp. 311-316
Author(s):  
S. Nassir Ghaemi

Seasonal affective illness is seen as part of the seasonality of affective illness, not as a separate disease. All human beings are sensitive to light; the impact of light is hardwired in neuroanatomy. The body has intricate circadian rhythms that are regulated by the interaction of light with this neuroanatomy. Thus, everyone is affected by light, or its absence. Manic and depressive states, when part of the disease of manic-depressive illness, can have a seasonal pattern, with depression more prevalent in the fall/winter and mania in the spring/summer. The high prevalence of suicide in the spring likely relates to mixed manic states. Treatment with light boxes can be helpful symptomatically. Available studies are summarized. Importantly, light precautions, which involve behavioral interventions to increase or decrease light exposure, can prevent seasonal mood episodes.


INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (09) ◽  
pp. 5-17
Author(s):  
D. B Bhavsar ◽  
◽  
U. S Desai ◽  
A. A Phatak ◽  
P. D Chaudhari .

Bipolar disorder (previously called manic depressive illness) is a medical condition involving changes in the brain function leading to dramatic mood swings. It is characterized by the occurrence of at least one manic or mixed-manic episode, commonly treated with mood stabilizers. Sometimes, antipsychotics and antidepressants are used along with mood stabilizers. Lithium, a very effective mood stabilizer, was the first anti-manic depressant drug approved by the USFDA in the 1970’s. Though the specific biochemical mechanism of its action is unknown, preclinical studies have shown that lithium alters sodium transport in nerve cells and effects a shift toward intraneuronal metabolism of catecholamine. Although lithium is drug of choice in the treatment of bipolar disorder, the safe dose range is relatively narrow, and therapeutic drug monitoring is needed in order to prevent toxic reaction after its oral administration. So, there is scope for the alternative route of administration of lithium, which gives optimum drug levels and produces effects in low dose.


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