A comparison of clustering solutions for cognitive heterogeneity in schizophrenia

1998 ◽  
Vol 4 (4) ◽  
pp. 353-362 ◽  
Author(s):  
GERALD GOLDSTEIN ◽  
DANIEL N. ALLEN ◽  
BRENT E. SEATON

A cluster analytic solution based upon a battery of tests consisting of the Halstead Category and Tactual Performance Tests, the Trail Making Test, and the Wisconsin Card Sorting Test was compared with a solution based on the subtests of the Wechsler intelligence scales, utilizing a sample of 221 schizophrenic patients. Both analyses permitted four-cluster solutions, and we found a weak but significant degree of association between solutions. Examination of external validity of the two solutions revealed stronger associations with clinical variables for the Wechsler-scale-based solution. The major conclusions were that the existence of cognitive heterogeneity in schizophrenia exists across a broad range of abilities, and appears to reflect a combination of continuity of ability level and existence of possible subtypes requiring further neuropsychological and neurobiological verification. (JINS, 1998, 4, 353–362.)

2014 ◽  
Vol 17 ◽  
Author(s):  
Tânia Silva ◽  
Luís Monteiro ◽  
Emanuela Lopes

AbstractAlthough several brief sensitive screening tools are available to detect executive dysfunction, few have been developed to quickly assess executive functioning. The INECO Frontal Screening (IFS) is a brief tool which has proved be useful for the assessment of the executive functions in patients with dementia. The aim of this study was to explore whether the IFS is as sensitive and specific as the BADS, a battery designed to assess the dysexecutive syndrome, in schizophrenia. Our sample comprised a group of 34 schizophrenic patients (Mean age = 39.59, DP = 10.697) and 31 healthy controls (Mean age = 35.52, DP = 10.211). To all groups were administered the BADS, Wisconsin Card Sorting Test and IFS. The results suggest that schizophrenic patients performed significantly worse than the control group in all tests (p < .05). The IFS total score was 13.29 for the experimental group and 26.21 for the control group (p < .001). Considering a cut-off of 14 points, the IFS sensitivity was 100% and specificity 56% in detection of executive dysfunction in schizophrenia, compared with the BADS, that if we consider a cut-off of 11 points, was a sensitivity of 100% and a specificity of 50%. Thus, IFS is a brief, sensitive and specific tool for the detection of executive dysfunction in schizophrenia.


2001 ◽  
Vol 251 (2) ◽  
pp. 66-71 ◽  
Author(s):  
Stefan Riehemann ◽  
Hans-Peter Volz ◽  
Peggy Stützer ◽  
Stefan Smesny ◽  
Christian Gaser ◽  
...  

2008 ◽  
Vol 102 (1-3) ◽  
pp. 91
Author(s):  
Patricia Ohrmann ◽  
Andreas Wilmsmeier ◽  
Jochen Bauer ◽  
Ansgar Siegmund ◽  
Thomas Suslow ◽  
...  

2011 ◽  
Vol 26 (S2) ◽  
pp. 1419-1419
Author(s):  
M.R. Khodaee ◽  
M.K. Derakhshan ◽  
A. Khodabakhshi Kooalee

ObjectivesThere is an evidence for differential executive function in bipolar type 1 disorder (B1D) and schizophrenia that may tend different cognitive deficits and abnormalities. The objective of this study was to compare the executive function of B1D and schizophrenic patients.MethodWe studied 50 patients with B1D, and 50 schizophrenic participants. All participants completed the Wisconsin Card Sorting Test (WCST) of the Persian version. The participants were match in three basic variables which had most contributions in cognitive conditions in patients. They were Age, educational status and period of illness.ResultsThe two patient groups had compared performance on the WCST. In the WCST, schizophrenic patients showed impairment executive function more than B1D patients.ConclusionsFindings indicated that schizophrenic patients had more dysfunctions executive function than the Bipolar type 1 disorder patients. Although, both disorders may show the impairment in executive function, but the dysfunction in schizophrenia greater than bipolar type 1disorder patients.


2013 ◽  
Vol 29 (1) ◽  
pp. 15-20
Author(s):  
Hugo Sousa ◽  
Manuel Machado ◽  
Jorge Quintas

Neste trabalho, tentamos identificar índices de simulação na avaliação neuropsicológica forense, através da avaliação dos padrões de resposta em provas neuropsicológicas. A amostra foi constituída por 56 sujeitos com traumatismo crânioencefálico. Todos se encontravam numa situação de possível recompensa monetária por incapacidade. Utilizamos os instrumentos Wisconsin Card Sorting Test (WCST), Trail Making Test (TMT), Inventário de Sintomas Psicopatológicos (BSI), e a grelha de análise dos autos do processo. Cerca de 30% da amostra enquadrou-se no grupo de prováveis simuladores. Essa porcentagem é congruente com a literatura. Verificou-se uma grande homogeneidade entre os indivíduos com e sem indicadores de simulação, a nível sintomatológico e características sócio-demográficas, o que reforça a necessidade de desenvolvimento de métodos eficazes na detecção da simulação.


2000 ◽  
Vol 12 (1) ◽  
pp. 27-31 ◽  
Author(s):  
M.G. Lanser ◽  
B.A. Ellenbroek ◽  
A.R. Cools ◽  
F.G. Zitman

SUMMARYPerseveration is a core symptom of schizophrenia, the cause, however, is unknown. It has been shown that for people with frontal lobe lesions, perseveration can be explained with a set-maintenance problem. Perseveration in Parkinson's disease can be explained with problems shifting from one set to another without cues (set-shifting). These disorders can be distinguished using a two-choice task and the Wisconsin Card Sorting Test, that is analysed in phases. Analogs of these tests can be used in animal research. By adding an animal part to the human research, more insight can be gained into the role of specific brain areas in set-maintenance and set-shifting.


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