Characterization of the role of microRNA-517a expression in low birth weight infants

2013 ◽  
Vol 4 (6) ◽  
pp. 522-526 ◽  
Author(s):  
G. Y. Song ◽  
W. W. Song ◽  
Y. Han ◽  
D. Wang ◽  
Q. Na
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Placental Tissue ◽  
Maternal Serum ◽  
Trophoblast Invasion ◽  
Normal Birth Weight ◽  
Serum Samples ◽  
Low Birth Weight Infants ◽  
Human Trophoblast ◽  
Normal Birth

The purpose of this study was to analyze the expression of the placenta-specific microRNA miR-517a in maternal serum and in placental tissue from low birth weight newborns and try to detect the effects of miR-517a expression on invasion potential of trophoblasts. Placental tissue and maternal serum were collected from both low birth weight newborns (n = 10) and normal birth weight newborns (n = 20). Expression of miR-517a was assessed in placenta and serum samples by real-time qRT-PCR. In addition, human trophoblast HTR8/SVneo cells were transfected with a miR-517a 2′-O-methyl oligonucleotide or a negative control RNA, and invasion was measured using transwell migration assays. Expression of miR-517a was significantly increased in placentas from low birth weight newborns (61.79 ± 23.06) in comparison with those of normal birth weight newborns (5.01 ± 1.97; P < 0.05). The expression of miR-517a was also increased in maternal serum isolated from the low birth weight newborn (25.78 ± 8.69) compared with the normal birth weight newborn (3.21 ± 1.07; P < 0.05). Overexpression of miR-517a significantly inhibited invasion of HTR8/SVneo cells (P < 0.05). These data indicate that miR-517a overexpression could potentially lead to low birth weight, likely through the inhibition of trophoblast invasion.

Nine-Year Outcome of the Vermont Intervention Program for Low Birth Weight Infants

PEDIATRICS ◽  
1993 ◽  
Vol 91 (1) ◽  
pp. 45-55
Author(s):  
Thomas M. Achenbach ◽  
Catherine T. Howell ◽  
Melanie F. Aoki ◽  
Virginia A. Rauh
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Child Behavior Checklist ◽  
Intervention Program ◽  
Attention Problems ◽  
Favorable Effect ◽  
Normal Birth Weight ◽  
Low Birth Weight Infants ◽  
Normal Birth ◽  
Teacher’S Report Form

Twenty-four low birth weight children who had received an experimental intervention (LBWE) during the neonatal period, 31 control children who had received no treatment (LBWC), and 36 normal birth weight children were compared. The intervention involved seven hospital sessions and four home sessions in which a nurse helped mothers adapt to their LBW babies. At age 9, LBWE children scored significantly higher than LBWC children on the Kaufman Mental Processing Composite, Sequential, Simultaneous, Achievement, Arithmetic, and Riddles scales, after statistical adjustments for socioeconomic status. The LBWE children had also advanced more rapidly in school than had LBWC children. Parent (Child Behavior Checklist) and teacher (Teacher's Report Form) ratings of school functioning were more favorable for LBWE than LBWC children, with especially strong effects on Teacher's Report Form scores for academic performance and the attention problems syndrome. At age 9, LBWE children were not significantly inferior to normal birth weight children on any measure. These results bear out a progressive divergence between the LBWE and LBWC children that first became statistically significant in cognitive scores at age 3. The findings suggest that the intervention prevented cognitive lags among LBW children and that this eventually had a favorable effect on academic achievement, behavior, and advancement in school. The progression from no significant differences between LBWE and LBWC children on early cognitive and achievement scores to significant and pervasive differences in later functioning argues for long-term follow-up periods to evaluate properly the power of behavioral interventions to compensate for biological risks.

Dr. Holliday's Reply

PEDIATRICS ◽  
1974 ◽  
Vol 54 (4) ◽  
pp. 524-524
Author(s):  
Malcolm A. Holliday
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nutritional Requirements ◽  
Normal Infant ◽  
Infant Formulas ◽  
Normal Birth Weight ◽  
Nutritional Knowledge ◽  
Low Birth Weight Infants ◽  
Normal Birth ◽  
Fda Regulations

The FDA regulations for infant formulas were directed to infants of normal birth weight and their nutritional requirements during the first 6 to 12 months of life. There are a number of problems relating to feeding of low-birth-weight infants that require the development of separate standards and separate formulas for those infants. The Committee on Nutrition presently is concerned with reviewing the nutritional knowledge relating to nutritional requirements for low-birth-weight infants. The copper requirement cited by Dr. Cordano is an example where the nutritional requirements of low-birth-weight infants differ significantly from those of the normal infant.

Antioxidant Levels in Cord Blood of Term Low Birth Weight Neonates Requiring Delivery Room Resuscitation

2021 ◽  
pp. 097321792199140
Author(s):  
Rimjhim Sonowal ◽  
Anamika Jain ◽  
V. Bhargava ◽  
H.D. Khanna ◽  
Ashok Kumar
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Vitamin A ◽  
Cord Blood ◽  
Serum Levels ◽  
Study Groups ◽  
Delivery Room ◽  
Normal Birth Weight ◽  
Normal Birth ◽  
Major Congenital Malformations

Objective: The objective of this study was to evaluate the serum levels of various antioxidants, namely, vitamin A and E, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) in the cord blood of term low birth weight (LBW) neonates who required delivery room resuscitation (DRR). Materials and Methods: This case control study included 37 term LBW neonates who needed DRR as cases and 44 term neonates as controls (15 term LBW and 29 term normal birth weight) who did not require resuscitation at birth. Neonates suffering from major congenital malformations, infection, or hemolytic disease were excluded. Standard methods were used to measure the levels of vitamin A, vitamin E, SOD, catalase, and GPx levels in the cord blood. Results: Vitamin A and E levels were significantly low in cases compared to term LBW controls as well as term normal birth weight controls. Levels of SOD, GPx, and catalase were comparable in different study groups. Conclusion: Our study shows that term LBW neonates requiring DRR had significantly low levels of vitamin A and E in their cord blood. This might compromise their ability to tolerate oxidative stress during DRR.

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