scholarly journals Characterisation of linkage disequilibrium and subsequent estimation of effective population size in Thoroughbred horses using single nucleotide polymorphism markers

2010 ◽  
Vol 1 (1) ◽  
pp. 58-58
Author(s):  
L J Corbin ◽  
S C Bishop ◽  
J E Swinburne ◽  
M Vaudin ◽  
S C Blott ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Linkage Disequilibrium ◽  
Population Size ◽  
Effective Population Size ◽  
Nucleotide Polymorphism ◽  
Effective Population ◽  
Single Nucleotide ◽  
Thoroughbred Horses

scholarly journals An empirical examination of sample size effects on population demographic estimates in birds using single nucleotide polymorphism (SNP) data

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9939
Author(s):  
Jessica F. McLaughlin ◽  
Kevin Winker
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Sample Size ◽  
Population Size ◽  
Effective Population Size ◽  
Population Level ◽  
Sample Sizes ◽  
Nucleotide Polymorphism ◽  
Effective Population ◽  
Single Nucleotide ◽  
Population Demographic

Sample size is a critical aspect of study design in population genomics research, yet few empirical studies have examined the impacts of small sample sizes. We used datasets from eight diverging bird lineages to make pairwise comparisons at different levels of taxonomic divergence (populations, subspecies, and species). Our data are from loci linked to ultraconserved elements and our analyses used one single nucleotide polymorphism per locus. All individuals were genotyped at all loci, effectively doubling sample size for coalescent analyses. We estimated population demographic parameters (effective population size, migration rate, and time since divergence) in a coalescent framework using Diffusion Approximation for Demographic Inference, an allele frequency spectrum method. Using divergence-with-gene-flow models optimized with full datasets, we subsampled at sequentially smaller sample sizes from full datasets of 6–8 diploid individuals per population (with both alleles called) down to 1:1, and then we compared estimates and their changes in accuracy. Accuracy was strongly affected by sample size, with considerable differences among estimated parameters and among lineages. Effective population size parameters (ν) tended to be underestimated at low sample sizes (fewer than three diploid individuals per population, or 6:6 haplotypes in coalescent terms). Migration (m) was fairly consistently estimated until <2 individuals per population, and no consistent trend of over-or underestimation was found in either time since divergence (T) or theta (Θ = 4Nrefμ). Lineages that were taxonomically recognized above the population level (subspecies and species pairs; that is, deeper divergences) tended to have lower variation in scaled root mean square error of parameter estimation at smaller sample sizes than population-level divergences, and many parameters were estimated accurately down to three diploid individuals per population. Shallower divergence levels (i.e., populations) often required at least five individuals per population for reliable demographic inferences using this approach. Although divergence levels might be unknown at the outset of study design, our results provide a framework for planning appropriate sampling and for interpreting results if smaller sample sizes must be used.

Chinese Holstein Cattle effective population size estimated from whole genome linkage disequilibrium

2012 ◽  
Vol 34 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Gui-Yan NI ◽  
Zhe ZHANG ◽  
Li JIANG ◽  
Pei-Pei MA ◽  
Qin ZHANG ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Population Size ◽  
Effective Population Size ◽  
Holstein Cattle ◽  
Whole Genome ◽  
Effective Population ◽  
Chinese Holstein ◽  
Chinese Holstein Cattle

scholarly journals Estimation of linkage disequilibrium and effective population size in New Zealand sheep using three different methods to create genetic maps

BMC Genetics ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Vincent Prieur ◽  
Shannon M. Clarke ◽  
Luiz F. Brito ◽  
John C. McEwan ◽  
Michael A. Lee ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
New Zealand ◽  
Population Size ◽  
Effective Population Size ◽  
Genetic Maps ◽  
Effective Population
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