Characterization of azoniaadamantane-based preservatives by combined reversed-phase cation-exchange chromatography with suppressed conductivity detection

1992 ◽  
Vol 64 (10) ◽  
pp. 1096-1099 ◽  
Author(s):  
William Russell. Summers
Keyword(s):  
Cation Exchange ◽  
Reversed Phase ◽  
Exchange Chromatography ◽  
Cation Exchange Chromatography ◽  
Conductivity Detection ◽  
Suppressed Conductivity Detection

Characterization of the Acidic Species of a Monoclonal Antibody Using Weak Cation Exchange Chromatography and LC-MS

2015 ◽  
Vol 87 (17) ◽  
pp. 9084-9092 ◽  
Author(s):  
Gomathinayagam Ponniah ◽  
Adriana Kita ◽  
Christine Nowak ◽  
Alyssa Neill ◽  
Yekaterina Kori ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cation Exchange ◽  
Exchange Chromatography ◽  
Cation Exchange Chromatography ◽  
Weak Cation Exchange

Chromatographic separations of diastereoisomers of the 5,7,12,14-tetramethyl-1,4,8,11 -tetraazacyclotetradeca-4,11-dienenickel(II) cation, and characterization of the nickel(II) complex of the new macrocyclic ligand 5,7,7,12,14-pentamethyl- 1,4,8,11 -tetraazacyclotetradeca-4,11-diene

1980 ◽  
Vol 33 (7) ◽  
pp. 1447 ◽  
Author(s):  
GH Searle ◽  
RW Hay ◽  
B Jeragh
Keyword(s):  
Cation Exchange ◽  
Column Chromatography ◽  
Macrocyclic Ligand ◽  
Exchange Chromatography ◽  
Cation Exchange Chromatography ◽  
Chromatographic Separations ◽  
Chiral Carbon ◽  
Diene Ligands

Planar nickel(II) complexes of different macrocyclic tetraazacyclotetradeca-4,11-diene ligands and diastereoisomers which differ in chiral carbon configurations have been separated by cation- exchange chromatography on SP-Sephadex C-25 resin. Of the limited number of successful eluents, sodium glycinate is the most effective. The separations are considered to result from differential associations between the glycinate anion and the complex cations. The technique has been successfully applied to the separation of the C-racemic and C-meso diastereoisomers of [Ni(ttcd)]2+ (ttcd = 5,7,12,14-tetramethyl-1,4,8,11- tetraazacyclotetradeca-4,11-diene). Diastereoisomers arising from chiral NH centres cannot be separated by this technique since the effective eluents are generally basic, causing epimerization. The use of 1H and 13C n.m.r. spectra in these studies is discussed, and the isolation of the nickel(II) complex of the new macrocyclic ligand ptcd (5,7,7,12,14-pentamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene) by column chromatography described. The isolated [Ni(ptcd)]-(ClO4)2 is a mixture of the diastereoisomers C-axial,N-racemic and C-axial,N-meso.

scholarly journals Application of High-performance Cation-exchange Chromatography for Characterization of Stinging Insect Venoms.

1983 ◽  
Vol 37b ◽  
pp. 252-254 ◽  
Author(s):  
Roland Einarsson ◽  
Ing-Mari Åstrand ◽  
Per Ålin ◽  
Bengt Mannervik ◽  
Jan-Eric Berg ◽  
...  
Keyword(s):  
Cation Exchange ◽  
High Performance ◽  
Exchange Chromatography ◽  
Cation Exchange Chromatography ◽  
Stinging Insect
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