Dynamic Range Expansion Applied to Mass Spectrometry Based on Data-Dependent Selective Ion Ejection in Capillary Liquid Chromatography Fourier Transform Ion Cyclotron Resonance for Enhanced Proteome Characterization

2001 ◽  
Vol 73 (21) ◽  
pp. 5052-5060 ◽  
Author(s):  
Mikhail E. Belov ◽  
Gordon A. Anderson ◽  
Nicolas H. Angell ◽  
Yufeng Shen ◽  
Nikola Tolic ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Liquid Chromatography ◽  
Range Expansion ◽  
Cyclotron Resonance ◽  
Dynamic Range ◽  
Capillary Liquid Chromatography ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron ◽  
Capillary Liquid

scholarly journals Micro-capillary liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry--a powerful tool for peptide and protein identification.

2001 ◽  
Vol 48 (4) ◽  
pp. 1101-1104 ◽  
Author(s):  
M Ramström ◽  
M Palmblad ◽  
A Amirkhani ◽  
Y O Tsybin ◽  
K E Markides ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Liquid Chromatography ◽  
Cyclotron Resonance ◽  
Protein Identification ◽  
Capillary Liquid Chromatography ◽  
Ion Cyclotron Resonance ◽  
Sequence Coverage ◽  
Tryptic Digest ◽  
Ion Cyclotron ◽  
Capillary Liquid

In order to be able to study complex biological samples, a micro-capillary liquid chromatography system was coupled to a 9.4 T Fourier transform ion cyclotron resonance mass spectrometer. The setup was tested on a tryptic digest of bovine serum albumin, which resulted in high sequence coverage (> 92%) of the protein.

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