Overcoming Matrix Effects in Liquid Chromatography−Mass Spectrometry

2008 ◽  
Vol 80 (23) ◽  
pp. 9343-9348 ◽  
Author(s):  
Achille Cappiello ◽  
Giorgio Famiglini ◽  
Pierangela Palma ◽  
Elisabetta Pierini ◽  
Veronica Termopoli ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Matrix Effects ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry

Overcoming matrix effects in electrospray: Quantitation of β-agonists in complex matrices by isotope dilution liquid chromatography–mass spectrometry using singly 13C-labeled analogues

2013 ◽  
Vol 1288 ◽  
pp. 40-47 ◽  
Author(s):  
Ana González-Antuña ◽  
Juan C. Domínguez-Romero ◽  
Juan F. García-Reyes ◽  
Pablo Rodríguez-González ◽  
Giuseppe Centineo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Isotope Dilution ◽  
Matrix Effects ◽  
Liquid Chromatography Mass Spectrometry ◽  
Complex Matrices ◽  
Chromatography Mass Spectrometry

scholarly journals New Developments in Liquid Chromatography Mass Spectrometry for the Determination of Micropollutants

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Zoraida Sosa-Ferrera ◽  
Cristina Mahugo-Santana ◽  
José Juan Santana-Rodríguez
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Performance ◽  
Flame Retardants ◽  
Matrix Effects ◽  
Liquid Chromatography Mass Spectrometry ◽  
Flight Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Endocrine Disrupting

The combination of liquid chromatography (LC) with mass spectrometry (MS) in the environmental field has appeared as a valuable tool for the determination of micropollutants. Several groups of compounds have been considered as particularly relevant (e.g., pharmaceuticals, hormones and other endocrine-disrupting, personal care products and their metabolites, flame retardants, surfactants, and plasticizers, among others) since the same ones are continuously being released in the environment mainly as a result of the manufacturing processes, the disposal of unused or expired products, and the excreta. Because these micropollutants are not completely removed in the environment, very specific and sensitive analytical procedures are needed for their identification and quantification. High performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) (or LC-MS2) and especially time-of-flight mass spectrometry (TOF/MS), has allowed that many environmental contaminants that are highly polar or nonvolatile or have a high molecular weight to be analyzed or identified. In this work we present an overview focused on the developments of liquid chromatography mass spectrometry applied to the analysis of the main classes of micropollutants in aqueous and solid environmental samples. Various aspects of methodologies based on these techniques, including sample preparation (extraction/preconcentration) and matrix effects, are discussed.

Aspects of Matrix Effects in Applications of Liquid Chromatography-mass Spectrometry to Catecholamine Analysis-a Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Saniye Özcan ◽  
Serkan Levent ◽  
Nafiz Öncü Can
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Pharmaceutical Industry ◽  
Matrix Effects ◽  
Tandem Mass ◽  
Liquid Chromatography Mass Spectrometry ◽  
Biological Matrices ◽  
Efficient Tool ◽  
Chromatography Mass Spectrometry ◽  
Catecholamine Analysis

Background: Recently, liquid chromatography based on tandem mass spectrometry (LC-MS/MS) has become an efficient tool in analyzes of many compounds in various biological matrices. However, as known by researchers, these biological matrices cause various interferences by suppressing (ion suppression) or increasing ionization (ion enhancement). Since this challenge was recognized in the 1990s, many studies have been published on it, and its causes have been reviewed countless times for various compounds. However, none of the current studies specifically addressed aspects of matrix effects that have to do with catecholamines. Discussion: This review will focus on these issues, critically discussing experiments and results of matrix effects in LC-MS/MS applications on catecholamine analysis in various biological matrices. Moreover, it can be guided on the performance of studies on matrix effects in LC-MS/MS procedures in bioanalytical systems. Conclusion: This article is useful for academics such as analytical chemists, pharmacologists and also members of the pharmaceutical industry working on catecholamines and liquid chromatography-mass spectrometry.

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