High-Speed, Comprehensive, Two Dimensional Separations of Peptides and Small Molecule Biological Amines Using Capillary Electrophoresis Coupled with Micro Free Flow Electrophoresis

2017 ◽  
Vol 89 (3) ◽  
pp. 1665-1673 ◽  
Author(s):  
Alexander C. Johnson ◽  
Michael T. Bowser
Keyword(s):  
Capillary Electrophoresis ◽  
Small Molecule ◽  
High Speed ◽  
Free Flow ◽  
Two Dimensional ◽  
Micro Free Flow Electrophoresis

Load Spectrum Compiling and Fatigue Life Estimation of the Automobile Wheel Hub

2020 ◽  
Vol 13 ◽  
Author(s):  
Xintian Liu ◽  
Yang Qu ◽  
Xiaobing Yang ◽  
Yongfeng Shen
Keyword(s):  
Fatigue Life ◽  
High Speed ◽  
Two Dimensional ◽  
Load Spectrum ◽  
One Dimensional ◽  
Life Estimation ◽  
Load Spectra ◽  
Fatigue Life Estimation ◽  
Program Load Spectrum ◽  
Program Load

Background:: In the process of high-speed driving, the wheel hub is constantly subjected to the impact load from the ground. Therefore, it is important to estimate the fatigue life of the hub in the design and production process. Objective:: This paper introduces a method to study the fatigue life of car hub based on the road load collected from test site. Methods:: Based on interval analysis, the distribution characteristics of load spectrum are analyzed. The fatigue life estimation of one - dimensional and two - dimensional load spectra is compared by compiling load spectra. Results:: According to the S-N curve cluster and the one-dimensional program load spectrum, the estimated range fatigue life of the hub is 397,100 km to 529,700 km. For unsymmetrical cyclic loading, each level means and amplitude of load were obtained through the Goodman fatigue empirical formula, and then according to S-N curve clusters in the upper and lower curves and two-dimensional program load spectrum, estimates the fatigue life of wheel hub of the interval is 329900 km to 435200 km, than one-dimensional load spectrum fatigue life was reduced by 16.9% - 17.8%. Conclusion:: This paper lays a foundation for the prediction of fatigue life and the bench test of fatigue durability of auto parts subjected to complex and variable random loads. At the same time, the research method can also be used to estimate the fatigue life of other bearing parts or high-speed moving parts and assemblies.

Accelerating laser processes with a smart two-dimensional polygon mirror scanner for ultra-fast beam deflection

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Florian Roessler ◽  
André Streek
Keyword(s):  
Energy Distribution ◽  
Real Time ◽  
Laser Processing ◽  
High Speed ◽  
Beam Deflection ◽  
Two Dimensional ◽  
Heat Accumulation ◽  
Field Programmable ◽  
Drill Holes ◽  
Average Laser

Abstract In laser processing, the possible throughput is directly scaling with the available average laser power. To avoid unwanted thermal damage due to high pulse energy or heat accumulation during MHz-repetition rates, energy distribution over the workpiece is required. Polygon mirror scanners enable high deflection speeds and thus, a proper energy distribution within a short processing time. The requirements of laser micro processing with up to 10 kW average laser powers and high scan speeds up to 1000 m/s result in a 30 mm aperture two-dimensional polygon mirror scanner with a patented low-distortion mirror configuration. In combination with a field programmable gate array-based real-time logic, position-true high-accuracy laser switching is enabled for 2D, 2.5D, or 3D laser processing capable to drill holes in multi-pass ablation or engraving. A special developed real-time shifter module within the high-speed logic allows, in combination with external axis, the material processing on the fly and hence, processing of workpieces much larger than the scan field.

An Efficient Match Search Approach Using Two-Dimensional Hash Function in Hardware-Based Dictionary Compression

2019 ◽  
Vol 28 (06) ◽  
pp. 1950106
Author(s):  
Qian Dong ◽  
Bing Li
Keyword(s):  
Compression Ratio ◽  
Hash Function ◽  
High Speed ◽  
Two Dimensional ◽  
Time Data ◽  
Search Result ◽  
Compression Speed ◽  
Real Time Data ◽  
Real Time Data Processing ◽  
Search Approach

The hardware-based dictionary compression is widely adopted for high speed requirement of real-time data processing. Hash function helps to manage large dictionary to improve compression ratio but is prone to collisions, so some phrases in match search result are not true matches. This paper presents a novel match search approach called dual chaining hash refining, which can improve the efficiency of match search. From the experimental results, our method showed obvious advantage in compression speed compared with other approach that utilizes single hash function described in the previous publications.

Investigation of Contact Conditions During Stamping of a Thin Plate

2020 ◽  
Author(s):  
Harshal Y. Shahare ◽  
Rohan Rajput ◽  
Puneet Tandon
Keyword(s):  
Wave Propagation ◽  
Material Properties ◽  
High Speed ◽  
Fdtd Method ◽  
Propagation Model ◽  
Transmitted Wave ◽  
Two Dimensional ◽  
Contact Conditions ◽  
Simulation Based ◽  
Difference Time

Abstract Stamping is one of the most used manufacturing processes, where real-time monitoring is quite difficult due to high speed of the mechanical press, which leads to deterioration of the accuracy of the products In the present work, a method is developed to model elastic waves propagation in solids to measure contact conditions between die and workpiece during stamping. A two-dimensional model is developed that reduces the wave propagation equations to two-dimensional equations. To simulate the wave propagation inside the die-workpiece model, the finite difference time domain (FDTD) method and modified Yee algorithm has been employed. The numerical stability of the wave propagation model is achieved through courant stability condition, i.e., Courant-Friedrichs-Lewy (CFL) number. Two cases, i.e., flat die-workpiece interface and inclined die-workpiece interface, are investigated in the present work. The elastic wave propagation is simulated with a two-dimension (2D) model of the die and workpiece using reflecting boundary conditions for different material properties. The experimental and simulation-based results of reflected and transmitted wave characteristics are compared for different materials in terms of reflected and transmitted wave height ratio and material properties such as acoustic impedance. It is found that the numerical simulation results are in good agreement with the experimental results.

scholarly journals INFLUENCE OF FREE-FLOW EXCIPIENTS ON FUNCTIONAL PERFORMANCE OF NOVEONAA1 IN CONTROLLED-RELEASE TABLETS

2016 ◽  
Vol 8 (9) ◽  
pp. 6
Author(s):  
RubÉn Ramos Islas ◽  
Leopoldo Villafuerte Robles
Keyword(s):  
Drug Release ◽  
High Speed ◽  
Functional Performance ◽  
Release Profile ◽  
Free Flow ◽  
Release Mechanism ◽  
Powder Flowability ◽  
Powder Flow Rate ◽  
Controlled Release Tablets ◽  
Better Than

<p><strong>Objective: </strong>The aim of this work is the assessment of an eventual improvement in flowability of free flowing excipients on formulations containing Noveon AA1 and their influence on compactibility and release profile.</p><p><strong>Methods: </strong>Mixtures containing 20% Noveon AA1 and variable proportions of metronidazole and the free flowing excipients Prosolv EasyTab and GalenIQ 720 and 721were tested in their powder flow rate and the tablets compactibility and released profiles.</p><p><strong>Results: </strong>The powder flowability obtained with GalenIQ is about 20% better than that obtained with EasyTab. However, it is lesser than that considered as acceptable for a high-speed tableting machine. EasyTab reduces the drug release up to a half along with a continuing flattening of the release profile. This is attributed to an increasing tortuosity of the drug release path as the proportion EasyTab increases. GalenIQ restricts drug release in about a third with a lesser change in the release mechanism. This is attributed to competition for the available water inside the tablet, between the hydrating Noveon AA1 and the dissolving GalenIQ. The compactibility of the metronidazole/Noveon AA1 mixtures increases after addition of EasyTab in about 3.5 N per unit percentage of the added excipient while GalenIQ does it in about 2.6 N.</p><p><strong>Conclusion: </strong>The powder flowability of mixtures of metronidazole with Noveon AA1 was not suited for direct compression after addition of 40% of the free-flow excipient. The free-flow excipients reduce the metronidazole release rate and increase its compactibility. It was not observed a different clear functioning between both types of GalenIQ.</p>

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