Partial Opening of Cytochrome P450cam (CYP101A1) Is Driven by Allostery and Putidaredoxin Binding

Biochemistry ◽  
2021 ◽  
Author(s):  
Simon P. Skinner ◽  
Alec H. Follmer ◽  
Marcellus Ubbink ◽  
Thomas L. Poulos ◽  
Jeanine J. Houwing-Duistermaat ◽  
...  
Keyword(s):  
Cytochrome P450cam ◽  
Partial Opening

scholarly journals 1P-121 Roles of Asp297 in the vicinity of the active site of cytochrome P450cam in substrate binding(The 46th Annual Meeting of the Biophysical Society of Japan)

2008 ◽  
Vol 48 (supplement) ◽  
pp. S40
Author(s):  
Keisuke Sakurai ◽  
Katsuyoshi Harada ◽  
Kunitoshi Shimokata ◽  
Takashi Hayashi ◽  
Hideo Shimada
Keyword(s):  
Annual Meeting ◽  
Active Site ◽  
Substrate Binding ◽  
Cytochrome P450cam ◽  
Biophysical Society

Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam

1995 ◽  
Vol 117 (14) ◽  
pp. 4185-4186 ◽  
Author(s):  
James J. De Voss ◽  
Paul R. Ortiz de Montellano
Keyword(s):  
Computer Assisted ◽  
Cytochrome P450cam

Ligand and Redox Partner Binding Generates a New Conformational State in Cytochrome P450cam (CYP101A1)

2019 ◽  
Vol 141 (6) ◽  
pp. 2678-2683 ◽  
Author(s):  
Alec H. Follmer ◽  
Sarvind Tripathi ◽  
Thomas L. Poulos
Keyword(s):  
Conformational State ◽  
Cytochrome P450cam ◽  
Redox Partner

Evidence for water binding to the Fe center in cytochrome P450cam obtained by 17O ESEEM, 1H four-pulse ESEEM and pulsed ENDOR

1995 ◽  
Vol 59 (2-3) ◽  
pp. 322 ◽  
Author(s):  
H. Thomann ◽  
D. Goldfarb ◽  
M. Bernardo ◽  
P.M.H. Kroneck ◽  
V. Ullrich
Keyword(s):  
Cytochrome P450cam ◽  
Water Binding

Flow-Induced Vibration Study of Tunnel Spillway Working Gate on One Reservoir

2012 ◽  
Vol 226-228 ◽  
pp. 13-16
Author(s):  
Xin Wang ◽  
Shao Ze Luo
Keyword(s):  
Dynamic Pressure ◽  
High Energy ◽  
Vibration Response ◽  
Analysis Method ◽  
Flow Induced Vibration ◽  
3D Fem ◽  
Fem Model ◽  
Tunnel Spillway ◽  
Partial Opening ◽  
Spillway Tunnel

In order to study the flow-induced vibration of the spillway tunnel working gate of one reservoir, hydraulic model test with scale 1:20 was conducted to obtain the dynamic pressure characteristics on the working gate. Experiment modal analysis method was employed to identify the structure dynamic characteristics through the 1:10 working gate mode test. The 3D FEM model of the gate was built to simulate the vibration response of the structure. The research showed the low order modal frequencies of the working gate were not fully breaking away from the high energy zone of the dynamic water, which would induce severe vibration. The vibration response of the gate became the biggest when it was operating at 0.5 partial opening.

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