pH-Sensitive Polymeric Vesicles for GOx/BSO Delivery and Synergetic Starvation-Ferroptosis Therapy of Tumor

2021 ◽  
Author(s):  
Yang Luo ◽  
Peng Yan ◽  
Xinyang Li ◽  
Jianwen Hou ◽  
Yi Wang ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Polymeric Vesicles

pH-Sensitive Polymeric Vesicles from Coassembly of Amphiphilic Cholate Grafted Poly(l-lysine) and Acid-Cleavable Polymer–Drug Conjugate

Langmuir ◽  
2012 ◽  
Vol 28 (33) ◽  
pp. 11988-11996 ◽  
Author(s):  
Lijun Zhu ◽  
Lingling Zhao ◽  
Xiaozhong Qu ◽  
Zhenzhong Yang
Keyword(s):  
Ph Sensitive ◽  
Drug Conjugate ◽  
Polymeric Vesicles

A Mechanism for Reversibly Pausing a Self-Immolation Cascade in Response to pH Changes

2019 ◽  
Author(s):  
Derrick Roberts ◽  
Ben S. Pilgrim ◽  
Tristan Dell ◽  
Molly Stevens
Keyword(s):  
Local Environment ◽  
Chemical Signals ◽  
Ph Sensitive ◽  
First Report ◽  
Ph Changes ◽  
Self Immolation

We describe the first report of a self-immolation cascade that can be reversibly paused and reactivated in response to pH changes. This system employs a triazole-based self-immolative linker, which expresses a pH-sensitive intermediate during its elimination sequence. This allows the system to respond to pH cues within its local environment, thus establishing a new way to gate self-immolative release using fluctuating or transient chemical signals.<br>

Sign in / Sign up

Export Citation Format

Share Document