Faculty Opinions recommendation of pH-sensitive vibrational probe reveals a cytoplasmic protonated cluster in bacteriorhodopsin.

Author(s):  
Qiang Cui
Keyword(s):  
2019 ◽  
Author(s):  
Derrick Roberts ◽  
Ben S. Pilgrim ◽  
Tristan Dell ◽  
Molly Stevens

We describe the first report of a self-immolation cascade that can be reversibly paused and reactivated in response to pH changes. This system employs a triazole-based self-immolative linker, which expresses a pH-sensitive intermediate during its elimination sequence. This allows the system to respond to pH cues within its local environment, thus establishing a new way to gate self-immolative release using fluctuating or transient chemical signals.<br>


BIO-PROTOCOL ◽  
2018 ◽  
Vol 8 (8) ◽  
Author(s):  
Aparecida Silva ◽  
Keini Dressano ◽  
Paulo Ceciliato ◽  
Juan Carlos Guerrero-Abad ◽  
Daniel Moura

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