pH-Sensitive Polymeric Vesicles from Coassembly of Amphiphilic Cholate Grafted Poly(l-lysine) and Acid-Cleavable Polymer–Drug Conjugate

Langmuir ◽  
2012 ◽  
Vol 28 (33) ◽  
pp. 11988-11996 ◽  
Author(s):  
Lijun Zhu ◽  
Lingling Zhao ◽  
Xiaozhong Qu ◽  
Zhenzhong Yang
Keyword(s):  
Ph Sensitive ◽  
Drug Conjugate ◽  
Polymeric Vesicles

Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel

2014 ◽  
Vol 194 ◽  
pp. 220-227 ◽  
Author(s):  
Shixian Lv ◽  
Zhaohui Tang ◽  
Dawei Zhang ◽  
Wantong Song ◽  
Mingqiang Li ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Release Mechanism ◽  
Drug Conjugate ◽  
Efficient Delivery

Synthesis of randomly aminated polyvinylpyrrolidone and its use in the preparation of hydrolyzable conjugates

RSC Advances ◽  
2014 ◽  
Vol 4 (68) ◽  
pp. 35950-35958 ◽  
Author(s):  
Anselmo del Prado ◽  
Rodrigo Navarro ◽  
Alberto Gallardo ◽  
Carlos Elvira ◽  
Helmut Reinecke
Keyword(s):  
Potential Application ◽  
Ph Sensitive ◽  
Drug Conjugate

Preparation of side-aminated polyvinylpyrrolidones and their potential application as pH-sensitive drug-conjugate carriers.

Multi pH-sensitive polymer–drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis

2020 ◽  
Vol 8 (18) ◽  
pp. 5029-5046 ◽  
Author(s):  
Yuanhang Zhou ◽  
Chuhang Zhou ◽  
Yang Zou ◽  
Yao Jin ◽  
Shidi Han ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Tumor Metastasis ◽  
Mixed Micelles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Drug Conjugate ◽  
Responsive Polymer ◽  
Ph Sensitive Polymer

Multi pH-responsive polymer-drug conjugate mixed micelles were fabricated to co-deliver doxorubicin and curcumin for synergistic suppression tumor metastasis via inhibiting the invasion, migration, intravasation and extravasation of tumor cells.

pH-Sensitive Polymeric Vesicles for GOx/BSO Delivery and Synergetic Starvation-Ferroptosis Therapy of Tumor

2021 ◽  
Author(s):  
Yang Luo ◽  
Peng Yan ◽  
Xinyang Li ◽  
Jianwen Hou ◽  
Yi Wang ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Polymeric Vesicles

A Mechanism for Reversibly Pausing a Self-Immolation Cascade in Response to pH Changes

2019 ◽  
Author(s):  
Derrick Roberts ◽  
Ben S. Pilgrim ◽  
Tristan Dell ◽  
Molly Stevens
Keyword(s):  
Local Environment ◽  
Chemical Signals ◽  
Ph Sensitive ◽  
First Report ◽  
Ph Changes ◽  
Self Immolation

We describe the first report of a self-immolation cascade that can be reversibly paused and reactivated in response to pH changes. This system employs a triazole-based self-immolative linker, which expresses a pH-sensitive intermediate during its elimination sequence. This allows the system to respond to pH cues within its local environment, thus establishing a new way to gate self-immolative release using fluctuating or transient chemical signals.<br>

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