The Bioinorganic Chemistry of Mammalian Metallothioneins

: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

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Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes

Current Opinion in Chemical Biology ◽

10.1016/j.cbpa.2021.01.016 ◽

2021 ◽

Vol 61 ◽

pp. 191-202

Author(s):

Austin C. Hachey ◽

Dmytro Havrylyuk ◽

Edith C. Glazer

Keyword(s):

Metal Complexes ◽

Biological Activities ◽

Bioinorganic Chemistry

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A laboratory program for bioinorganic chemistry

Journal of Chemical Education ◽

10.1021/ed050p610 ◽

1973 ◽

Vol 50 (9) ◽

pp. 610 ◽

Cited By ~ 7

Author(s):

Ei-ichiro Ochiai

Keyword(s):

Bioinorganic Chemistry

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Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes

Bioinorganic Chemistry and Applications ◽

10.1155/2010/168030 ◽

2010 ◽

Vol 2010 ◽

pp. 1-10 ◽

Cited By ~ 14

Author(s):

Stergios Zanias ◽

Giannis S. Papaefstathiou ◽

Catherine P. Raptopoulou ◽

Konstantinos T. Papazisis ◽

Vasiliki Vala ◽

...

Keyword(s):

Ir Spectroscopy ◽

Single Crystal ◽

Antiproliferative Activity ◽

Bioinorganic Chemistry ◽

Anionic Complex ◽

X Ray ◽

X Ray Crystallography ◽

Mononuclear Complexes ◽

Human And Mouse ◽

Antiproliferative Activities

As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd withGaBr3orGaCl3resulted in the mononuclear complexes[GaBr3(btaH)2](1) and[GaCl3(btd)2](2), respectively, while treatment ofGaCl3with L resulted in the anionic complex(LH)2[GaCl4](3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.

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