Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Concerning Trends for Current-Use PFAS

Author(s):  
Guomao Zheng ◽  
Erika Schreder ◽  
Jennifer C. Dempsey ◽  
Nancy Uding ◽  
Valerie Chu ◽  
...  
Chemosphere ◽  
2021 ◽  
pp. 132601
Author(s):  
Linda R. Macheka ◽  
Ovokeroye A. Abafe ◽  
Liziwe L. Mugivhisa ◽  
Joshua O. Olowoyo

2018 ◽  
Vol 25 (36) ◽  
pp. 36064-36086 ◽  
Author(s):  
Linda R. Macheka-Tendenguwo ◽  
Joshua O. Olowoyo ◽  
Liziwe L. Mugivhisa ◽  
Ovokeroye A. Abafe

2021 ◽  
Vol 157 ◽  
pp. 106855
Author(s):  
Santosh Lamichhane ◽  
Heli Siljander ◽  
Daniel Duberg ◽  
Jarno Honkanen ◽  
Suvi M. Virtanen ◽  
...  

2021 ◽  
Author(s):  
Santosh Lamichhane ◽  
Heli Siljander ◽  
Daniel Duberg ◽  
Jarno Honkanen ◽  
Suvi M. Virtanen ◽  
...  

AbstractBackgroundChemical composition of human breast milk is highly variable inter- and intra-individually. Environmental factors are suspected to partly explain the compositional variation, however, their impact on breast milk composition is currently poorly understood.ObjectivesWe sought (1) to define the impact of maternal exposure to per- and polyfluoroalkyl substances (PFAS) on lipid composition of human breast milk, and (2) to study the combined impact of maternal PFAS exposure and breast milk lipid composition on the growth of the infants.MethodsIn a mother-infant study (n=44) we measured the levels of PFAS and lipids in maternal serum and conducted lipidomics analysis of breast milk at birth and at 3 months of infant age, by using ultra high performance liquid chromatography combined with quadrupole-time-of-flight mass spectrometry. Maternal diet was studied by a validated food frequency questionnaire.ResultsPFAS levels were inversely associated with total lipid levels in the breast milk collected at birth. In the high exposure group, the ratio of acylated saturated and polyunsaturated fatty acids in triacylglycerols was increased. Moreover, high exposure to PFAS associated with the altered phospholipid composition, which was indicative of unfavorable increase in the size of milk fat globules. These changes in the milk lipid composition were further associated with slower infant growth and with elevated intestinal inflammatory markers.DiscussionOur data suggest that the maternal exposure to PFAS impacts the nutritional quality of the breast milk, which, in turn, may have detrimental impact on the health and growth of the children later in life.


2001 ◽  
Vol 120 (5) ◽  
pp. A209-A209
Author(s):  
G RIEZZO ◽  
R CASTELLANA ◽  
T DEBELLIS ◽  
F LAFORGIA ◽  
F INDRIO ◽  
...  

Ob Gyn News ◽  
2007 ◽  
Vol 42 (22) ◽  
pp. 13
Author(s):  
TIMOTHY F. KIRN
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2005 ◽  
Vol 39 (3) ◽  
pp. 8
Author(s):  
DIANA MAHONEY
Keyword(s):  

2005 ◽  
Vol 35 (5) ◽  
pp. 30
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  

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