Toxicological Effect and Molecular Mechanism of the Chiral Neonicotinoid Dinotefuran in Honeybees

2021 ◽  
Author(s):  
Quan Zhang ◽  
Lili Fu ◽  
Tao Cang ◽  
Tao Tang ◽  
Mingcheng Guo ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Toxicological Effect

scholarly journals T-2 Toxin Induces Oxidative Stress, Apoptosis and Cytoprotective Autophagy in Chicken Hepatocytes

Toxins ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 90 ◽  
Author(s):  
Huadong Yin ◽  
Shunshun Han ◽  
Yuqi Chen ◽  
Yan Wang ◽  
Diyan Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Molecular Mechanism ◽  
Regulatory Mechanism ◽  
Fusarium Species ◽  
Cereal Grains ◽  
Oxygen Species ◽  
Related Protein ◽  
Pathological Changes ◽  
Toxicological Effect ◽  
Type A Trichothecenes

T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. T-2 toxin has been shown to induce a series of toxic effects on the health of human and animal, such as immunosuppression and carcinogenesis. Previous study has proven that T-2 toxin caused hepatotoxicity in chicken, but the regulatory mechanism is unclear. In the present study, we assessed the toxicological effect of T-2 toxin on apoptosis and autophagy in hepatocytes. The total of 120 1-day-old healthy broilers were allocated randomly into four groups and reared for 21 day with complete feed containing 0 mg/kg, 0.5 mg/kg, 1 mg/kg or 2 mg/kg T-2 toxin, respectively. The results showed that the apoptosis rate and pathological changes degree hepatocytes were aggravated with the increase of T-2 toxin. At the molecular mechanism level, T-2 toxin induced mitochondria-mediated apoptosis by producing reactive oxygen species, promoting cytochrome c translocation between the mitochondria and cytoplasm, and thus promoting apoptosomes formation. Meanwhile, the expression of the autophagy-related protein, ATG5, ATG7 and Beclin-1, and the LC3-II/LC3-I ratio were increased, while p62 was downregulated, suggesting T-2 toxin caused autophagy in hepatocytes. Further experiments demonstrated that the PI3K/AKT/mTOR signal may be participated in autophagy induced by T-2 toxin in chicken hepatocytes. These data suggest a possible underlying molecular mechanism for T-2 toxin that induces apoptosis and autophagy in chicken hepatocytes

Additional evidence for AQP1 vesicle trafficking as a molecular mechanism for ductal bile secretion

2001 ◽  
Vol 120 (5) ◽  
pp. A91-A91
Author(s):  
P TIETZ ◽  
P SPLINTER ◽  
M MCNIVEN ◽  
R HUEBERT ◽  
N LARUSSO
Keyword(s):  
Molecular Mechanism ◽  
Vesicle Trafficking ◽  
Bile Secretion

Hypoxia/Reoxygenation on human myometrial and decidual cells: A molecular mechanism involved in preterra labor

1998 ◽  
Vol 5 (1) ◽  
pp. 187A-187A
Author(s):  
J CARVAJAL ◽  
S KATO ◽  
J SAEZ ◽  
F LEIGHTON ◽  
G VALENZUELA ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Decidual Cells ◽  
Hypoxia Reoxygenation

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

Molecular mechanism of hippocampal injury: Roles of glucocorticoids and cytokines

2000 ◽  
Vol 38 ◽  
pp. S17
Author(s):  
I Hideki
Keyword(s):  
Molecular Mechanism

The molecular mechanism of Silexan: Neurotrophic effects via CREB activation might explain preclinical antidepressant properties

2013 ◽  
Vol 46 (06) ◽  
Author(s):  
G Sillani ◽  
C Schiller ◽  
K Leuner ◽  
WE Müller
Keyword(s):  
Molecular Mechanism ◽  
Creb Activation

The molecular mechanism of n-butanol extracts of Panax notoginseng on RANKL-induced osteoclastogenesis in RAW264.7 cells

2014 ◽  
Author(s):  
Hyo-In Hwang ◽  
Young-Joo Jang ◽  
Seon-Yle Ko
Keyword(s):  
Molecular Mechanism ◽  
Panax Notoginseng ◽  
Raw264.7 Cells

Bone Remodeling: The Molecular Mechanism of Bone Physiology- A Review

2012 ◽  
Vol 3 (4) ◽  
pp. 305-306 ◽  
Author(s):  
Biplob Chowdhury ◽  
Keyword(s):  
Bone Remodeling ◽  
Molecular Mechanism ◽  
Bone Physiology
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