Transplacental Transfer of Per- and Polyfluoroalkyl Substances Identified in Paired Maternal and Cord Sera Using Suspect and Nontarget Screening

2020 ◽  
Vol 54 (6) ◽  
pp. 3407-3416 ◽  
Author(s):  
Yuqian Li ◽  
Nanyang Yu ◽  
Letian Du ◽  
Wei Shi ◽  
Hongxia Yu ◽  
...  
Keyword(s):  
Transplacental Transfer ◽  
Nontarget Screening ◽  
Polyfluoroalkyl Substances

scholarly journals The transplacental transfer efficiency of per- and polyfluoroalkyl substances (PFAS): a first meta-analysis

2021 ◽  
pp. 1-20
Author(s):  
Mareike Appel ◽  
Martin Forsthuber ◽  
Romualdo Ramos ◽  
Raimund Widhalm ◽  
Sebastian Granitzer ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Transfer Efficiency ◽  
Transplacental Transfer ◽  
Polyfluoroalkyl Substances

Suspect and Nontarget Screening of Per- and Polyfluoroalkyl Substances in Wastewater from a Fluorochemical Manufacturing Park

2018 ◽  
Vol 52 (19) ◽  
pp. 11007-11016 ◽  
Author(s):  
Yi Wang ◽  
Nanyang Yu ◽  
Xiaobin Zhu ◽  
Huiwei Guo ◽  
Jianguo Jiang ◽  
...  
Keyword(s):  
Nontarget Screening ◽  
Polyfluoroalkyl Substances

scholarly journals Nontarget Screening of Per- and Polyfluoroalkyl Substances Binding to Human Liver Fatty Acid Binding Protein

2020 ◽  
Vol 54 (9) ◽  
pp. 5676-5686 ◽  
Author(s):  
Diwen Yang ◽  
Jiajun Han ◽  
David Ross Hall ◽  
Jianxian Sun ◽  
Jesse Fu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Human Liver ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Liver Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Nontarget Screening ◽  
Polyfluoroalkyl Substances

Structure-Based Virtual Screening of Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) as Endocrine Disruptors of Androgen Receptor Activity Using Molecular Docking and Machine Learning

2020 ◽  
Author(s):  
Azhagiya Singam Ettayapuram Ramaprasad ◽  
Phum Tachachartvanich ◽  
Denis Fourches ◽  
Anatoly Soshilov ◽  
Jennifer C.Y. Hsieh ◽  
...  
Keyword(s):  
Machine Learning ◽  
Molecular Docking ◽  
Androgen Receptor ◽  
Endocrine Disruptors ◽  
Hormone Receptors ◽  
Steroid Hormone Receptors ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Polyfluoroalkyl Substances ◽  
Perfluoroalkyl And Polyfluoroalkyl Substances

Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) pose a substantial threat as endocrine disruptors, and thus early identification of those that may interact with steroid hormone receptors, such as the androgen receptor (AR), is critical. In this study we screened 5,206 PFASs from the CompTox database against the different binding sites on the AR using both molecular docking and machine learning techniques. We developed support vector machine models trained on Tox21 data to classify the active and inactive PFASs for AR using different chemical fingerprints as features. The maximum accuracy was 95.01% and Matthew’s correlation coefficient (MCC) was 0.76 respectively, based on MACCS fingerprints (MACCSFP). The combination of docking-based screening and machine learning models identified 29 PFASs that have strong potential for activity against the AR and should be considered priority chemicals for biological toxicity testing.

Electrochemical Oxidation of Perfluorooctanesulfonate by Magnéli Phase Ti4O7 Electrode in the Presence of Trichloroethylene

2020 ◽  
Vol 1 (4) ◽  
Author(s):  
Peizeng Yang ◽  
Yaye Wang ◽  
Junhe Lu ◽  
Viktor Tishchenko ◽  
Qingguo Huang ◽  
...  
Keyword(s):  
Electrochemical Oxidation ◽  
Current Density ◽  
First Order ◽  
Degradation Rates ◽  
Oxidation Technology ◽  
Magnéli Phase ◽  
Polyfluoroalkyl Substances ◽  
Titanium Suboxide ◽  
Gas Tight ◽  
Magneli Phase

This study examined the degradation of perfluorooctanesulfonate (PFOS) in electrochemical oxidation (EO) processes in the presence of trichloroethylene (TCE). The EO experiment was performed in a gas-tight reactor using Magnéli phase titanium suboxide (Ti4O7) as the anode. The experimental data demonstrated that 75% of PFOS (2 μM) was degraded at 10 mA/cm2 current density in 30 min without TCE present in the solution, while the presence of 76 μM TCE apparently inhibited the degradation of PFOS, reducing its removal down to 53%. Defluorination ratio suggested that PFOS was significantly mineralized upon EO treatment, and it appeared to be not influenced by the presence of TCE. The respective pseudo-first order rate constants (kobs) of PFOS removal were 0.0471 and 0.0254 min-1 in the absence and presence of TCE. The degradation rates of both PFOS and TCE increased with current density rising from 2.5 to 20 mA/cm2. In the presence of TCE, chloride, chlorate, and perchlorate were formed that accounted for 79.7 %, 5.53%, and 1.51% of the total chlorine at 60 min. This work illustrates the promise of the Magnéli phase Ti4O7 electrode based electrochemical oxidation technology for degrading per- and polyfluoroalkyl substances (PFASs) and co-contaminants in groundwaters.

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