Cannabis Seed Oil Alleviates Experimental Atherosclerosis by Ameliorating Vascular Inflammation in Apolipoprotein-E-Deficient Mice

2021 ◽  
Author(s):  
Wenjing Huang ◽  
Zhujun Zeng ◽  
Yan Lang ◽  
Xia Xiang ◽  
Gaofu Qi ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Seed Oil ◽  
Vascular Inflammation ◽  
Experimental Atherosclerosis ◽  
Deficient Mice

scholarly journals Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E–Deficient Mice

Circulation ◽  
2018 ◽  
Vol 138 (16) ◽  
pp. 1706-1719 ◽  
Author(s):  
Tomoya Hara ◽  
Pham Tran Phuong ◽  
Daiju Fukuda ◽  
Koji Yamaguchi ◽  
Chie Murata ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Vascular Inflammation ◽  
Critical Role ◽  
Protease Activated Receptor 2 ◽  
Deficient Mice

Immunoglobulin treatment suppresses atherosclerosis in apolipoprotein E-deficient mice via the Fc portion

2003 ◽  
Vol 285 (2) ◽  
pp. H899-H906 ◽  
Author(s):  
Zuyi Yuan ◽  
Chiharu Kishimoto ◽  
Hideto Sano ◽  
Keisuke Shioji ◽  
Yang Xu ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Immunohistochemical Analysis ◽  
Immunoglobulin Therapy ◽  
Experimental Atherosclerosis ◽  
Cytotoxic Activities ◽  
Fatty Streak ◽  
Atherosclerotic Lesions ◽  
Immune Mediated ◽  
Deficient Mice ◽  
Macrophage Accumulation

Atherosclerosis is associated with immune activation. Immunoglobulin is used for the treatment of immune-mediated diseases. The mechanisms and importance of the Fc portion of immunoglobulin upon experimental atherosclerosis in apolipoprotein E-deficient mice were examined. Experimental atherosclerosis was induced in mice fed a high-fat diet containing 0.3% cholesterol. Over 8, 12, and 16 wk, on alternate days, mice were treated with an intraperitoneal injection of either 1 g·kg–1·day–1of human intact immunoglobulin or F(ab′)2fragments of human immunoglobulin. Fatty streak formation and fibrofatty plaques were markedly suppressed in mice that received intact immunoglobulin for 8, 12, and 16 wk. In contrast, atherosclerotic lesions were not ameliorated in mice that received F(ab′)2fragments. Immunohistochemical analysis revealed that macrophage accumulation in the fatty streak lesions was suppressed in mice received intact immunoglobulin but not in those that received F(ab′)2fragments. In addition, the cytotoxic activities of splenocytes from immunoglobulin-treated mice, but not from F(ab′)2fragment-treated mice, were significantly suppressed compared with those from human serum albumin-treated mice. Differences in lesion area did not correlate with any significant alterations in serum lipid levels. Immunoglobulin therapy markedly suppressed atherosclerosis due to Fc receptor-mediated anti-inflammatory and immunomodulating actions. The antiatherosclerotic effects of immunoglobulin may be related to the suppression of cytotoxic activity of atherogenic T cells and the reduction of macrophage accumulation in the lesions.

Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice

2012 ◽  
Vol 425 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Fumitake Usui ◽  
Koumei Shirasuna ◽  
Hiroaki Kimura ◽  
Kazuki Tatsumi ◽  
Akira Kawashima ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Vascular Inflammation ◽  
Critical Role ◽  
Western Diet ◽  
Caspase 1 ◽  
Deficient Mice

scholarly journals Effect of Kokuto, a Non-Centrifugal Cane Sugar, on the Development of Experimental Atherosclerosis in Japanese Quail and Apolipoprotein E Deficient Mice

2007 ◽  
Vol 13 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Masashi INAFUKU ◽  
Takayoshi TODA ◽  
Takafumi OKABE ◽  
Koji WADA ◽  
Kensaku TAKARA ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Japanese Quail ◽  
Experimental Atherosclerosis ◽  
Cane Sugar ◽  
Deficient Mice

scholarly journals Effects of Late Administration of Immunoglobulin on Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice

2005 ◽  
Vol 69 (12) ◽  
pp. 1543-1546 ◽  
Author(s):  
Taka-aki Okabe ◽  
Chiharu Kishimoto ◽  
Kana Shimada ◽  
Toshinori Murayama ◽  
Masayuki Yokode ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Experimental Atherosclerosis ◽  
Deficient Mice

scholarly journals Effects of MCI-186 (Edaravone), a Novel Free Radical Scavenger, Upon Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice

2006 ◽  
Vol 70 (9) ◽  
pp. 1216-1219 ◽  
Author(s):  
Taka-aki Okabe ◽  
Chiharu Kishimoto ◽  
Kana Shimada ◽  
Toshinori Murayama ◽  
Masayuki Yokode ◽  
...  
Keyword(s):  
Free Radical ◽  
Apolipoprotein E ◽  
Experimental Atherosclerosis ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Deficient Mice
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